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Łysyganicz, Paweł K. Pooranachandran, Niedharsan Liu, Xinming Adamson, Kathryn I. Zielonka, Katarzyna Elworthy, Stone van Eeden, Fredericus J. Grierson, Andrew J. Malicki, Jarema J.
Published in
Frontiers in Cell and Developmental Biology
Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 conformation in primary cilia or 9 + 2 in motile cilia. These microtubules facilitate transport of intr...
Łysyganicz, Paweł K Pooranachandran, Niedharsan Liu, Xinming Adamson, Kathryn I Zielonka, Katarzyna Elworthy, Stone van Eeden, Fredericus J Grierson, Andrew J Malicki, Jarema J
Cilia are evolutionarily highly conserved organelles with important functions in many organs. The extracellular component of the cilium protruding from the plasma membrane comprises an axoneme composed of microtubule doublets, arranged in a 9 + 0 conformation in primary cilia or 9 + 2 in motile cilia. These microtubules facilitate transport of intr...
Seidel, Carole Marc Diederich Mazumder, Aloran Kirsch, Gilbert Dicato, Mario Michael Schnekenburger Marie-Hélène Teiten
Published in
Biochemical Pharmacology
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including α-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc
Published in
Epigenomics
Histone deacetylase (HDAC)6 is a member of the class IIb HDAC family. This enzyme is zinc-dependent and mainly localized in the cytoplasm. HDAC6 is a unique isoenzyme with two functional catalytic domains and specific physiological roles. Indeed, HDAC6 deacetylates various substrates including α-tubulin and HSP90α, and is involved in protein traffi...
Chen, Poshen B. Hung, Jui-Hung Hickman, Taylor L. Coles, Andrew H. Carey, James F. Weng, Zhiping Chu, Feixia Fazzio, Thomas G.
In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs. Hdac6 is necessary for regulation of most Tip60-p400 target genes, particularly those ...
Chen, Poshen B Hung, Jui-Hung Hickman, Taylor L Coles, Andrew H Carey, James F Weng, Zhiping Chu, Feixia Fazzio, Thomas G
Published in
eLife
In embryonic stem cells (ESCs), the Tip60 histone acetyltransferase activates genes required for proliferation and silences genes that promote differentiation. Here we show that the class II histone deacetylase Hdac6 co-purifies with Tip60-p400 complex from ESCs. Hdac6 is necessary for regulation of most Tip60-p400 target genes, particularly those ...
