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Seidel, Carole Marc Diederich Mazumder, Aloran Kirsch, Gilbert Dicato, Mario Michael Schnekenburger Marie-Hélène Teiten
Published in
Biochemical Pharmacology
Histone deacetylase (HDAC)6 is a unique isoenzyme targeting specific substrates including α-tubulin and heat shock protein (HSP)90. HDAC6 is involved in protein trafficking and degradation, cell shape and migration. Deregulation of HDAC6 activity is associated with a variety of diseases including cancer leading to a growing interest for developing ...
Seidel, Carole Schnekenburger, Michael Dicato, Mario Diederich, Marc
Published in
Cancer letters
Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate cellular processes by modifying the acetylation status of many proteins. Pathologically altered HDAC activity contributes to cancer development and thus characterization of novel acetylation modulators is important for future anti-cancer therapies. In this study, we identif...
Nicolas Gillet Fabian Vandermeers Alix de Brogniez Arnaud Florins Annamaria Nigro Carole François Amel-Baya Bouzar Olivier Verlaeten Eric Stern Didier M. Lambert
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We previously proved that a histone deacetylase inhibitor (valproate, VPA) decreases the number of leukemic cells in bovine leukemia virus (BLV)-infected sheep. Here, we characterize the mechanisms initiated upon interruption of treatment. We observed that VPA treatment is followed by a decrease of the B cell counts and proviral loads (copies per b...
Murakami Jun Asaumi Jun-ichi Kawai Noriko Tsujigiwa Hidetsugu Yanagi Yoshinobu Nagatsuka Hitoshi Inoue Tetsuyoshi Kokeguchi Susumu Kawasaki Shoji Kuroda Masahiro
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We speculated whether or not the expression level of telomerase reverse transcriptase (hTERT) would be modulated by agents targeting epigenetics in oral cancer cell lines. Although hTERT is known to be targeted by epigenetic changes, it remains unclear how chemoagents targeting epigenetics work on hTERT transcription. In the present study, the epig...
J. S. Riley R. Hutchinson D. G. McArt N. Crawford C. Holohan I. Paul S. Van Schaeybroeck M. Salto-Tellez P. G. Johnston D. A. Fennell
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Non-small cell lung carcinoma remains by far the leading cause of cancer-related deaths worldwide. Overexpression of FLIP, which blocks the extrinsic apoptotic pathway by inhibiting caspase-8 activation, has been identified in various cancers. We investigated FLIP and procaspase-8 expression in NSCLC and the effect of HDAC inhibitors on FLIP expres...
