All elements with two or more isotopes show natural variation in their isotopic composition as a result of the isotope fractionation that accompanies (bio)chemical reactions and (bio)physical processes. Multicollector inductively coupled plasma-mass spectrometry (MC-ICP-MS) offers the precision required to reveal and quantify the differences in iso...
The aim of this exploratory clinical study was to evaluate whether the preanalytical quality of blood samples subjected to delayed centrifugation and transport - as a result of home-sampling - is affected in a way it alters the clinical decision-making for patients under systemic cancer therapy. This evaluation is part of a comprehensive investigat...
Isotopic reference materials (IRMs) are crucial for securing accurate and precise isotope ratio measurements of non-traditional stable isotopic systems and for enabling comparison of isotope ratio data obtained at different labs. Fe and Mg isotopic analysis have gained considerable interest as it expands our understanding of critical geological and...
Published in Bioanalysis
Conventional sampling techniques for clinical pharmacokinetic studies often require the removal of large blood volumes from patients. This can result in a physiological or emotional burden, particularly for neonates or pediatric patients. Antibiotic pharmacokinetic studies are typically performed on healthy adults or general ward patients. These ma...
Published in Analytical and Bioanalytical Chemistry
Biological reference materials with well-characterised stable isotope compositions are lacking in the field of ‘isotope biochemistry’, which seeks to understand bodily processes that rely on essential metals by determining metal stable isotope ratios. Here, we present Zn stable isotope data for six biological reference materials with certified trac...
In this work, Fe isotopic analysis of samples obtained from an in vitro intestinal model was performed via multi-collector ICP-mass spectrometry (MC-ICP-MS) to evaluate the isotope fractionation accompanying Fe uptake and transport mechanisms at a cellular level. The Caco-2 cell line has been used, after cell differentiation, as an enterocyte model...
High-precision isotopic analysis of Fe in blood is currently assessed as a complementary approach to achieve a better understanding of human Fe metabolism and for diagnosis of diseases. Volumetric absorptive microsampling (VAMS) is a recently introduced technique that allows the straightforward collection of a well-defined volume of blood by dippin...
