The Rho family of small GTPases act as molecular switches in the cell and are involved in signalling pathways implicated in cytoskeletal organisation. To mediate their effects, they interact with downstream effectors. The protein kinase C-related kinase (PRK) family of serine/threonine kinases consists of three members, PRK1, PRK2 and PRK3, all of ...
Published in Biomolecular NMR Assignments
TOCA1 is a downstream effector protein of the small GTPase, Cdc42. It is a multi-domain protein that includes a membrane binding F-BAR domain, a homology region 1 (HR1) domain, which binds selectively to active Cdc42 and an SH3 domain. TOCA1 is involved in the regulation of actin dynamics in processes such as endocytosis, filopodia formation, neuri...
TOCA1 is a downstream effector protein of the small GTPase, Cdc42. It is a multi-domain protein that includes a membrane binding F-BAR domain, a homology region 1 (HR1) domain, which binds selectively to active Cdc42 and an SH3 domain. TOCA1 is involved in the regulation of actin dynamics in processes such as endocytosis, filopodia formation, neuri...
La formation du complexe de fusion qui précède la fusion est essentielle à l infection de la cellule-cible par le VIH-1. L inhibition de la formation de ce complexe de fusion peut empêcher l infection et représenter un moyen de traitement antirétroviral. Plusieurs équipes ont essayé de produire des anticorps neutralisants par immunisation de souris...
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