Haderlein, Marlen von der Grün, Jens Balermpas, Panagiotis Rödel, Claus Hautmann, Matthias G. Steger, Felix Bohr, Christopher Hehr, Thomas Stromberger, Carmen Budach, Volker
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Published in
Frontiers in Oncology
Background Current standard treatment concepts in head and neck squamous cell carcinoma (HNSCC) are based on former studies using 2D and 3D treatment plans. However, modern radiation techniques allow for a more precise and individual dose application. Therefore, in a clearly defined patient population, de-intensified risk-adapted radiation is inves...
Brunelli, Laura Valent, Francesca Comar, Manola Suligoi, Barbara Salfa, Maria Cristina Gianfrilli, Daniele Sesti, Franz Restivo, Vincenzo Casuccio, Alessandra Gazzetta, Silvia
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Published in
Frontiers in Public Health
Sexually transmitted infections (STIs) are one of the most important issues related to sexual and reproductive health, as it is estimated that more than 1 million new infections are acquired every day worldwide and data on the prevalence and incidence of these infections, especially among young people, are increasing. Nevertheless, there are some k...
Chung, Ryan S. Wong, Stephanie Lin, Dechen Kokot, Niels C. Sinha, Uttam K. Han, Albert Y.
Published in
Frontiers in Oncology
Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer globally. Notably, human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is on the rise, accounting for 70% of all OPSCC cases. Persistent high-risk HPV infection is linked to various cancers, but HPV infection alone is not sufficient to cause ...
Kumar, Roshan Iden, Marissa Tsaih, Shirng-Wern Schmidt, Rachel Ojesina, Akinyemi I. Rader, Janet S.
Published in
Frontiers in Cell and Developmental Biology
Cervical cancer remains a significant health challenge for women worldwide, with a disproportionate impact on developing regions like sub-Saharan Africa. Taking advantage of recent advancements in developing suitable preclinical models to study cell proliferation, differentiation, and gene expression, we used RNA sequencing to compare the transcrip...
Wu, Meng Huang, Hui Tang, Ying Ren, Xuze Jiang, Xinrui Tian, Man Li, Wei
Published in
Frontiers in Immunology
Human Papillomavirus (HPV), an extensive family of DNA viruses, manifests as a persistent global health challenge. Persistent HPV infection is now firmly established as a significant aetiological factor for a spectrum of malignancies. In this review, we examine the latest insights into HPV biology and its intricate relationship with the host. We de...
Yang, Zheng Mansour, Jobran Sun, Peng Wei, Peng Dahlstrom, Kristina R Zafereo, Mark Li, Guojun Gross, Neil D
Published in
Head & neck
Differences in pretreatment body mass index (BMI) have been associated with survival in squamous cell carcinoma of head and neck (SCCHN). We examined effects of BMI on survival in SCCHN patients after stratifying patients by tumor human papillomavirus (HPV) status and subsite. Totally 2204 SCCHN patients in a prospective study were included in this...
Jose, Leny Smith, Keely Crowner, Anaiya Androphy, Elliot J. DeSmet, Marsha
Published in
Journal of Virology
Papillomaviruses contain small circular genomes of approximately 8 kilobase pairs and undergo unidirectional transcription from the sense strand of the viral genome. Co-transcriptional R-loops were recently reported to be present at high levels in cells that maintain episomal HPV and were also detected at the early viral promoter. R-loops can inhib...
Jose, Leny Smith, Keely Crowner, Anaiya Androphy, Elliot J. DeSmet, Marsha
Published in
Journal of Virology
Papillomaviruses contain small circular genomes of approximately 8 kilobase pairs and undergo unidirectional transcription from the sense strand of the viral genome. Co-transcriptional R-loops were recently reported to be present at high levels in cells that maintain episomal HPV and were also detected at the early viral promoter. R-loops can inhib...
Zonta, Marco A. Liljander, Anne Roque, Karina B. Schillert, Arne Kai, Marco dos Santo, Flávia A. de Freitas, Giulia Pinheiro Soane, Michel Cavalar, Markus Janaudis, Gustavo
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Published in
Frontiers in Public Health
Introduction Sexually transmitted infections (STIs) cause considerable morbidity worldwide and, depending on the specific pathogen, may lead to serious complications in the female reproductive tract. Incarcerated women are particularly vulnerable to health problems with a disproportionate high rate of STIs, including infections with human papilloma...
Bittew, Sisay Melese Masresha, Seteamlak Adane Mulaw, Getahun Fentaw Yimam, Mohammed Ahmed Zimamu, Abiot Alebel Abriham, Atnaf Alem Kidie, Atitegeb Abera
Published in
Frontiers in Global Women's Health
Background The cells of the cervical epithelial wall are the source of the malignant tumor caused by the human papilloma virus (HPV) known as cervical cancer. In 2018, Ethiopia implemented the HPV vaccine specifically targeting girls aged 9–14 years. This vaccination initiative serves as an effective preventive measure against cervical cancer, prov...
