Apergi, Kiriaki Karatzi, Kalliopi Reppas, Kyriakos Karaglani, Eva Usheva, Natalya Giménez-Legarre, Natalia Moreno, Luis A Dimova, Roumyana Antal, Emese Jemina, Kivelä
...
Published in
European journal of clinical nutrition
This study aimed to investigate the association of breakfast consumption frequency (BCF) with glycemic control indices in a cross-sectional sample of adults from families at high risk for type 2 diabetes mellitus (T2DM), exploring the role of sex and socioeconomic status (SES). In 2370 adults (40.8 ± 5.6 years) from 6 European countries, sociodemog...
linyan, qi li;
The incidence of inflammatory bowel disease (IBD) has increased in recent years. Considering the potential side effects of conventional drugs, safe and efficient treatment methods for IBD are required urgently. Natural polysaccharides (NPs) have attracted considerable attention as potential therapeutic agents for IBD owing to their high efficiency,...
Kaps, Leonard Huppertsberg, Anne Choteschovsky, Niklas Klefenz, Adrian Durak, Feyza Schrörs, Babara Diken, Mustafa Eichler, Emma Rosigkeit, Sebastian Schmitt, Sascha
...
Published in
Proceedings of the National Academy of Sciences of the United States of America
Immune-suppressive (M2-type) macrophages can contribute to the progression of cancer and fibrosis. In chronic liver diseases, M2-type macrophages promote the replacement of functional parenchyma by collagen-rich scar tissue. Here, we aim to prevent liver fibrosis progression by repolarizing liver M2-type macrophages toward a nonfibrotic phenotype b...
Scarpellini, Emidio; Balsiger, Lukas M; 143781; Maurizi, Valentina; Rinninella, Emanuele; Gasbarrini, Antonio; Giostra, Nena; Santori, Pierangelo; Abenavoli, Ludovico; Rasetti, Carlo;
Microelements represent an emerging resource for medicine and its preventive branch. Zinc is the second most abundant element in our organism with peculiar physiologic functions and pathophysiologic implications in systemic and gastrointestinal (GI) diseases. It interacts very often with gut microbiota (GM) and can affect natural course of GI disea...
Bignon, Yohan; Rinaldi, Anna; Nadour, Zahia; Poindessous, Virginie; Nemazanyy, Ivan; Lenoir, Olivia; Fohlen, Baptiste; Weill-Raynal, Pierre; Hertig, Alexandre; Karras, Alexandre;
...
The biosynthetic routes leading to de novo nicotinamide adenine dinucleotide (NAD+) production are involved in acute kidney injury (AKI), with a critical role for quinolinate phosphoribosyl transferase (QPRT), a bottleneck enzyme of de novo NAD+ biosynthesis. The molecular mechanisms determining reduced QPRT in AKI, and the role of impaired NAD+ bi...
Maschalidi, Sophia Mehrotra, Parul Keçeli, Burcu Nur De Cleene, Hannah Lecomte, Kim Van der Cruyssen, Renée Janssen, Pauline Pinney, Jonathan van Loo, Geert Elewaut, Dirk
...
Chronic non-healing wounds are a major complication of diabetes, which affects 1 in 10 people worldwide. Dying cells in the wound perpetuate the inflammation and contribute to dysregulated tissue repair1-3. Here we reveal that the membrane transporter SLC7A11 acts as a molecular brake on efferocytosis, the process by which dying cells are removed, ...
Steenbrugge, Jonas Bellemans, Julie Vander Elst, Niels Demeyere, Kristel De Vliegher, Josephine Perera, Timothy De Wever, Olivier Van Den Broeck, Wim De Spiegelaere, Ward Sanders, Niek
...
Aggressive triple-negative breast cancer (TNBC) is classically treated with chemotherapy. Besides direct tumor cell killing, some chemotherapeutics such as cisplatin provide additional disease reduction through stimulation of anti-tumor immunity. The cisplatin-induced immunomodulation in TNBC was here investigated in-depth using immunocompetent int...
Teng, Fei Tachó-Piñot, Roser Sung, Biin Farber, Donna L Worgall, Stefan Hammad, Hamida Lambrecht, Bart N Hepworth, Matthew R Sonnenberg, Gregory F
Published in
Cell reports
Group 3 innate lymphoid cells (ILC3s) critically regulate host-microbe interactions in the gastrointestinal tract, but their role in the airway remains poorly understood. Here, we demonstrate that lymphoid-tissue-inducer (LTi)-like ILC3s are enriched in the lung-draining lymph nodes of healthy mice and humans. These ILC3s abundantly express major h...
calatayud;, marta
Fermentation is an ancient food preservation process, and fermented products have been traditionally consumed in different cultures worldwide over the years. The interplay between human gut microbiota, diet and host health is widely recognized. Diet is one of the main factors modulating gut microbiota potentially with beneficial effects on human he...
Ju, Young-Jun Lee, Sung-Woo Kye, Yoon-Chul Lee, Gil-Woo Kim, Hee-Ok Yun, Cheol-Heui Cho, Jae-Ho
There is heterogeneity in the response to self-ligands within the naive CD8(+) T cell pool and the consequences of this are unclear. Here the authors show subsets of naive CD8(+) T cells which differ in expression of Ly6C and CD5 and response to viral infection through regulation by type I IFN signalling. The strength of the T cell receptor interac...
