Hong, Feiyu Jacobs, Jana L Aga, Evgenia Cillo, Anthony R Fyne, Elizabeth Koontz, Dianna L Zheng, Lu Mellors, John W
Published in
Virology
The relationships between HIV-1 DNA copy number, proviral transcriptional activity, and residual plasma viremia in individuals off and on ART are not well defined. To address this, we performed a cross-sectional study of 12 viremic donors and 23 ART-treated virologically suppressed (plasma HIV-1 RNA
Lombardi, Francesca Belmonti, Simone Rapone, Lucrezia Borghetti, Alberto Ciccullo, Arturo Gagliardini, Roberta Baldin, Gianmaria Montagnani, Francesca Moschese, Davide Emiliozzi, Arianna
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Published in
Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology
The influence of HIV-1 co-receptor usage on the course of therapy in subjects fully responding to ART has been poorly investigated. To explore the relationship between co-receptor tropism and cellular reservoir size, residual viremia and subsequent virological outcome in ART-treated patients with HIV-1 RNA stable 50 copies/mL) were evaluated over 9...
Pan, Yong Zhan, Shenshan Xia, Fan
Published in
Analytical biochemistry
ZIF-8(zinc-methylimidazolate framework-8), one of the zeolitic imidazolate frameworks (ZIFs), as quenching platforms for detection of HIV-1 DNA, which was identified to be effective for highly sensitive detection of HIV-1 DNA. The enhanced fluorescence signal has a relationship with the ssDNA concentration, the detection limit is as low as 1.2 nmol...
Bendenoun, M. Samri, A. Avettand-Fènoël, V. Cardinaud, S. Descours, B. Carcelain, G. Mazeron, M.-C. Bergmann, J.-F. Urrutia, A. Moris, A.
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BACKGROUND: We describe a homosexual man who strongly controlled HIV-1 for ten years despite lack of protective genetic background. METHODS: HIV-1 DNA was measured in blood and other tissues. Cell susceptibility was evaluated with various strains. HIV-1-specific (CD4 and CD8 activation markers and immune check points) and NK cells responses were as...
Gantner, Pierre Mélard, Adeline Damond, Florence Delaugerre, Constance Dina, Julia Gueudin, Marie Maillard, Anne Sauné, Karine Rodallec, Audrey Tuaillon, Edouard
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Published in
Journal of medical virology
Viral reservoirs represent an important barrier to HIV cure. Accurate markers of HIV reservoirs are needed to develop multicenter studies. The aim of this multicenter quality control (QC) was to evaluate the inter-laboratory reproducibility of total HIV-1-DNA quantification. Ten laboratories of the ANRS-AC11 working group participated by quantifyin...
Bon, Isabella Calza, Leonardo Musumeci, Giuseppina Longo, Serena Bertoldi, Alessia D'Urbano, Vanessa Gibellini, Davide Magistrelli, Eleonora Viale, Pier Luigi Re, Maria Carla
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Published in
Current HIV research
Total HIV-DNA load in peripheral blood cell (PBMCs) reflects the global viral reservoir that seems not to be affected by antiretroviral treatment. However, some studies reported a different permeability of different drugs in cellular compartments. To investigate the relation between the amount of total HIV-1 DNA and different treatment strategies. ...
Surdo, Matteo Bertoli, Ada Colucci, Giuseppe Sarmati, Loredana Andreoni, Massimo Perno, Carlo Federico Ceccherini-Silberstein, Francesca Ciotti, Marco
Published in
Clinical Chemistry and Laboratory Medicine (CCLM)
Mitchell, Caroline Dross, Sandra Beck, Ingrid A Micek, Mark A Frenkel, Lisa M
Published in
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Among infants exposed to human immunodeficiency virus type 1 (HIV-1), detection of viral infection at birth was increased by 39% (95% confidence interval, 19%-47%) by increasing DNA input from dried blood spots into polymerase chain reaction. Infants with low concentrations of HIV-1 at birth may be the best target population to evaluate whether imm...
Di Biagio, Antonio Parisini, Andrea Bruzzone, Bianca Prinapori, Roberta Lauriola, Marinella Paolucci, Stefania Signori, Alessio Barresi, Renata Icardi, Giancarlo Calderisi, Silvia
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Published in
HIV clinical trials
The aim of this study was to determine the coreceptor tropism by performing genotypic HIV-1 tropism testing in a cohort of patients perinatally infected with HIV-1 and exposed to antiretroviral therapy. Genotypic coreceptor tropism was determined in patients with HIV-1 RNA
Minga, Albert Anglaret, Xavier Toni, Thomas-D'Aquin Chaix, Marie-Laure Dohoun, Lambert Abo, Yao Coulibaly, Ali Duvignac, Julien Gabillard, Delphine Rouet, François
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OBJECTIVE: To analyze the association between the HIV-1 DNA level in peripheral blood mononuclear cells (PBMCs) and disease progression in recently infected West African adults. METHODS: HIV-1 DNA levels were measured in the PBMCs of 200 adults in the French National Agency for Research on AIDS and viral Hepatitis (ANRS) 1220 cohort who had recentl...