Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-beta
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status: published
Harnessing Type I IFN Immunity Against SARS-CoV-2 with Early Administration of IFN-β
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Published in Journal of Clinical Immunology
Autoantibodies and Donor-specific Antibodies are Associated With Graft Dysfunction in Pediatric Liver Transplantation.
Published in Journal of pediatric gastroenterology and nutrition
Autoantibodies (AAb) and donor-specific HLA antibodies (DSA) are frequently present in pediatric liver transplant (LT) recipients. Their clinical significance remains incompletely understood. We aimed to investigate the prevalence of serum AAb and DSA in pediatric LT recipients and its correlation with patient characteristics and histological and b...
Spontaneous liver disease in wild-type C57BL/6JOlaHsd mice fed semisynthetic diet
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Mouse models are frequently used to study mechanisms of human diseases. Recently, we observed a spontaneous bimodal variation in liver weight in C57BL/6JOlaHsd mice fed a semisynthetic diet. We now characterized the spontaneous variation in liver weight and its relationship with parameters of hepatic lipid and bile acid (BA) metabolism. In male C57...
Mediating effect of soluble B-cell activation immune markers on the association between anthropometric and lifestyle fac...
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Sustained B-cell activation is an important mechanism contributing to B-cell lymphoma (BCL). We aimed to validate four previously reported B-cell activation markers predictive of BCL risk (sCD23, sCD27, sCD30, and CXCL13) and to examine their possible mediating effects on the association between anthropometric and lifestyle factors and major BCL su...
DNASE1L3 as an indicator of favorable survival in hepatocellular carcinoma patients following resection
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Hepatocellular carcinoma (HCC) is a common malignancy with a dismal prognosis. It is of great importance to identify biomarkers for the prediction of patients' survival.The mRNA expression level of deoxyribonuclease 1 like 3 (DNASE1L3) and its correlation with survival were accessed in 424 samples from The Cancer Genome Atlas database. Its expressi...
Can infections trigger alpha-synucleinopathies?
As synucleinopathies, Parkinson's disease (PD) and multiple system atrophy (MSA) are neurodegenerative diseases that involve the spread of pathogenic alpha-synuclein (αSyn) throughout the brain. Recent studies have suggested a role for αSyn as an antimicrobial peptide in response to PD- and MSA-related infections of peripheral tissues, including th...
Challenges and opportunities in the clinical development of immune checkpoint inhibitors for hepatocellular carcinoma
After a decade of stagnation in drug development, therapeutic reversal of immune-exhaustion with immune checkpoint inhibitors (ICPI) has been shown to be effective in advanced hepatocellular carcinoma (HCC). The clinical development of novel ICPIs continues at a rapid pace, with more than 50 clinical trials of immunotherapeutic agents registered as...
Refusal to provide healthcare to sub-Saharan migrants in France: a comparison according to their HIV and HBV status
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In this study, we aim to measure and compare the frequency of reported denial of care in sub-Saharan African migrants living in the Paris area, according to their HIV and HBV status and social and migration characteristics.The ANRS-PARCOURS study is a life-event survey conducted in 2012–13 in healthcare facilities in the Paris area, among three gro...
Rapid and sensitive detection of viral nucleic acids using silicon microchips
Clinical laboratory-based nucleic acid amplification tests (NAT) play an important role in diagnosing viral infections. However, laboratory infrastructure requirements and their failure to diagnose at the point-of-need (PON) limit their clinical utility in both resource-rich and -limited clinical settings. The development of fast and sensitive PON ...
