The Fe isotopic composition of an individual's whole blood has recently been shown to be an interesting clinical indicator of Fe status. The present study aimed to evaluate the influence of several endemic characteristics of a representative population of the South Kivu province, an Fe-rich volcanic African region, on the whole blood Fe isotopic co...
Background: Fructosamine 3 kinase (FN3K) is a deglycating enzyme, which may play a key role in reducing diabetes- induced organ damage by removing bound glucose from glycated proteins. We wanted to develop a simple colorimetric method for assaying FN3K activity in human body fluids. Methods: Glycated bovine serum albumin (BSA) was obtained by glyca...
Due to major advances in the understanding of iron metabolism as well as in the biochemical, imaging, and genetic domains : i) The nosological framework of hemochromatosis (HC) encompasses not only HFE-HC, by far the most frequent HC form, but also non-HFE HC diseases which comprise essentially juvenile HC and the ferroportin disease. ii) The diagn...
Published in Human biology
Hereditary hemochromatosis is caused by a potentially lethal recessive gene (HFE, C282Y allele) that increases iron absorption and reaches polymorphic levels in northern European populations. Because persons carrying the allele absorb iron more readily than do noncarriers, it has often been suggested that HFE is an adaptation to anemia. We hypothes...
Case Description-3 hornbills (2 Papua hornbills [Aceros plicatus] and 1 longtailed hornbill [Tockus albocristatus]) were evaluated because of general listlessness and loss of feather glossiness. Clinical Findings-Because hepatic iron storage disease was suspected, liver biopsy was performed and formalin-fixed liver samples were submitted for histol...
The Q248H mutation in the gene SLC40A1 which encodes for the cellular iron exporter ferroportin is relatively common in Africa. This mutation has been associated with resistance to hepcidin and therefore we hypothesized that iron-related parameters and the prevalence of opportunistic infections in HIV might be influenced by the Q248H mutation. We c...
FAPESP Fundacao de Amparo a Pesquisa do Estado de Sao Paulo[05/50407-3]
FAPESP Fundacao de Amparo a Pesquisa do Estado de Sao Paulo[05/50407-3]
