Hariyono, Pandu Kotta, Jasvidianto Chriza Adhipandito, Christophorus Fideluno Aprilianto, Eko Candaya, Evan Julian Wahab, Habibah A. Hariono, Maywan
Published in
Applied Biological Chemistry
The H1N1 pandemic in 2009 and the H5N1 outbreak in 2005 have shocked the world as millions of people were infected and hundreds of thousands died due to the infections by the influenza virus. Oseltamivir, the most common drug to block the viral life cycle by inhibiting neuraminidase (NA) enzyme, has been less effective in some resistant cases due t...
Serpa Neto, Ary Burrell, Aidan J C Bailey, Michael Broadley, Tessa Cooper, D Jamie French, Craig J Pilcher, David Plummer, Mark P Trapani, Tony Webb, Steve A
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Published in
Annals of the American Thoracic Society
Rationale: Both 2009 pandemic influenza A (H1N1) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are transmitted by respiratory secretions and in severe cases result in a viral pneumonitis, requiring intensive care unit (ICU) admission. However, no studies have compared the clinical characteristics and outcomes of such patients. Ob...
Parihar, Shivay Kaur, Rimple Jeet Singh, Surjit
Published in
Journal of Family Medicine and Primary Care
With an increasing frequency of infectious disease outbreaks, the COVID-19 pandemic causing mortality around the world and the threat of similar future events looming large, mankind is faced with the herculean task of counteracting such threats with the best possible strategies and public health decisions. It is key that such decisions should be gu...
Berg, Siv Hilde O’Hara, Jane K. Shortt, Marie Therese Thune, Henriette Brønnick, Kolbjørn Kallesten Lungu, Daniel Adrian Røislien, Jo Wiig, Siri
Published in
BMC Public Health
BackgroundResponses from the H1N1 swine flu pandemic and the recent COVID-19 coronavirus pandemic provide an opportunity for insight into the role of health authorities’ ways of communicating health risk information to the public. We aimed to synthesise the existing evidence regarding different modes of communication used by health authorities in h...
Sun, Bo Guo, Xiang Wen, Xue Xie, Yun-Bo Liu, Wei-Hua Pang, Gui-Fen Yang, Lin-Ying Zhang, Qing
Published in
International Journal of Physiology, Pathophysiology and Pharmacology
Objective: Identifying the disease-associated interactions between different genes helps us to find novel therapeutic targets and predictive biomarkers. Methods: Gene expression data GSE82050 from H1N1 and control human samples were acquired from the NCBI GEO database. Highly co-expressed genes were grouped into modules. Through Person’s correlatio...
Li, Heng Zhao, Xin Zhao, Yurong Li, Jing Zheng, Huiwen Xue, Mengyi Guo, Lei Zhou, Jian Yang, Jinling Zuo, Yuanyuan
...
Published in
Emerging Microbes & Infections
The risk of secondary infection with SARS-CoV-2 and influenza A virus is becoming a practical problem that must be addressed as the flu season merges with the COVID-19 pandemic. As SARS-CoV-2 and influenza A virus have been found in patients, understanding the in vivo characteristics of the secondary infection between these two viruses is a high pr...
Jones, Christopher W. Adams, Amanda C. Murphy, Elizabeth King, Rachel P. Saracco, Benjamin Stesis, Karen R. Cavanaugh, Susan Roberts, Brian W. Platts-Mills, Timothy F.
Published in
BMC Medical Research Methodology
BackgroundPandemic events often trigger a surge of clinical trial activity aimed at rapidly evaluating therapeutic or preventative interventions. Ensuring rapid public access to the complete and unbiased trial record is particularly critical for pandemic research given the urgent associated public health needs. The World Health Organization (WHO) e...
Liu, Bo Bao, LinLin Wang, Li Li, Fengdi Wen, Mingjie Li, Hui Deng, Wei Zhang, Xulong Cao, Bin
Published in
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Severe infection with influenza A (H1N1)pdm09 virus is characterized by acute lung injury. The limited efficacy of anti-viral drugs indicates an urgent need for additional therapies. We have previously reported that neutralization of gamma interferon (IFN-γ) could significantly rescue the thymic atrophy induced by severe influenza A (H1N1)pdm09 inf...
Bai, Bingke Xu, Zhe Hu, Yan Qu, Mengmeng Cheng, Juan Luo, Shengdong Yao, Zengtao Gao, Hongyan Ma, Yenv Gao, Rong
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Published in
European Journal of Medical Research
BackgroundHematological comparison of coronavirus disease (COVID-19) and other viral pneumonias can provide insights into COVID-19 treatment.MethodsIn this retrospective case–control single-center study, we compared the data of 126 patients with viral pneumonia during different outbreaks [severe acute respiratory syndrome (SARS) in 2003, influenza ...
Zarei, Fariba Jalli, Reza Iranpour, Pooya Sefidbakht, Sepideh Soltanabadi, Sahar Rezaee, Maryam Jahankhah, Reza Manafi, Alireza
Published in
Academic Radiology
Objectives To investigate the chest CT and clinical characteristics of COVID-19 pneumonia and H1N1 influenza, and explore the radiologist diagnosis differences between COVID-19 and influenza. Materials and methods This cross-sectional study included a total of 43 COVID-19-confirmed patients (24 men and 19 women, 49.90 ± 18.70 years) and 41 influenz...
