Avendano, Esther E. Raman, Gowri Chan, Jeffrey McCann, Eilish
Published in
Antimicrobial Resistance & Infection Control
BackgroundOwing to their resistance to an important class of antibiotics, the prevention and treatment of carbapenem-resistant (CR)/non-susceptible Gram-negative (GN) infections has become an important public health objective. We conducted a systematic review and meta-analysis of published literature to evaluate the burden of CR GN infections, focu...
Sirajuddin, Salwa Abdullah Sundram, Shamala
Published in
Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]
Both Gram-positive and Gram-negative bacteria can take up exogenous DNA when they are in a competent state either naturally or artificially. However, the thick peptidoglycan layer in Gram-positive bacteria's cell wall is considered as a possible barrier to DNA uptake. In the present work, two transformation techniques have been evaluated in assessi...
Aliakbar Dehno Khalaji, Soleymanifard, Mahbobeh Jarosova, Marketa Machek, Pavel
Published in
Journal of Surface Investigation: X-ray, Synchrotron and Neutron Techniques
AbstractIn the present work, copper(II) oxide nanoparticles were prepared using simple and low-cost from calcination of CuSO4 or Cu(OAC)2 at the presence of polyvinyl alcohol (PVA) in a weight ratio of 1 : 1 at 600°C for 3 h. The basic properties of CuO nanoparticles were described by Fourier Transform Infrared (FT-IR) spectroscopy, powder X-ray di...
Hussein, Maytham Hu, Xiaohan Paulin, Olivia K.A. Crawford, Simon Tony Zhou, Qi Baker, Mark Schneider-Futschik, Elena K. Zhu, Yan Li, Jian Velkov, Tony
...
Published in
Computational and Structural Biotechnology Journal
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable. Combining antibiotics with various FDA-approved non-antibiotic drugs has emerged as a novel strategy against otherwise untreatable multi-drug re...
Koizumi, Yusuke Sakanashi, Daisuke Ohno, Tomoko Nakamura, Akiko Yamada, Atsuko Shibata, Yuichi Shiota, Arufumi Kato, Hideo Hagihara, Mao Asai, Nobuhiro
...
Published in
Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi
Procalcitonin (PCT) is an early diagnosis marker of sepsis/bacteremia. However, some reports refer to its lower responsiveness to gram-positive bacteremia. We retrospectively evaluated the PCT values at the onset of bacteremia in relation to severity index. Patients with bacteremia caused by two gram-negative bacteria (46 E. coli and 50 Klebsiella ...
Perdigão Neto, Lauro Vieira Oliveira, Maura Salaroli Orsi, Tatiana D'Annibale Prado, Gladys Villas Boas do Martins, Roberta Cristina Ruedas Leite, Gleice Cristina Marchi, Ana Paula Lira, Esther Sant'Ana de Côrtes, Marina Farrel Espinoza, Evelyn Patricia Sanchez
...
Published in
Journal of global antimicrobial resistance
Enterobacterales and other non-fermenting Gram-negative bacteria have become a threat worldwide owing to the frequency of multidrug resistance in these pathogens. On the other hand, efficacious therapeutic options are quickly diminishing. The aims of this study were to describe the susceptibility of 50 multiresistant Gram-negative bacteria, mostly ...
Garland, Keira Pantua, Homer Braun, Marie-Gabrielle Burdick, Daniel J Castanedo, Georgette M Chen, Yi-Chen Cheng, Yun-Xing Cheong, Jonathan Daniels, Blake Deshmukh, Gauri
...
Published in
Bioorganic & medicinal chemistry letters
Discovery of novel classes of Gram-negative antibiotics with activity against multi-drug resistant infections is a critical unmet need. As an essential member of the lipoprotein biosynthetic pathway, lipoprotein signal peptidase II (LspA) is an attractive target for antibacterial drug discovery, with the natural product inhibitor globomycin offerin...
Axford, Samuel B Andersen, Chad C Stark, Michael J
Published in
The Australian & New Zealand journal of obstetrics & gynaecology
While many guidelines recommend a 10-day course of oral erythromycin following preterm prelabour rupture of membranes (PPROM) as derived from the ORACLE I trial, evidence is emerging that this may encourage a state of antenatal genital tract dysbiosis. In addition, erythromycin's lack of efficacy toward Gram-negative microorganisms may promote colo...
Huang, Tao Kumari, Sushma Herold, Heike Bargel, Hendrik Aigner, Tamara B Heath, Daniel E O’Brien-Simpson, Neil M O’Connor, Andrea J Scheibel, Thomas
Published in
International Journal of Nanomedicine
Purpose Selenium nanoparticles (Se NPs) are promising antibacterial agents to tackle the growing problem of antimicrobial resistance. The aim of this study was to fabricate Se NPs with a net positive charge to enhance their antibacterial efficacy. Methods Se NPs were coated with a positively charged protein – recombinant spider silk protein eADF4(κ...
Palwe, Snehal Khobragade, Kshama Kharat, Arun S
Published in
Microbial drug resistance (Larchmont, N.Y.)
Appropriate empiric therapy reduces mortality and morbidity associated with serious Gram-negative infections. β-lactams (BLs) owing to their safety, efficacy, and coverage spectrum are the most preferred agents for empiric use. Inappropriate use of older penicillins and cephalosporins led to selection and spread of resistant clones. As a result, th...
