Wei, Ruixue Fu, Gaoliang Li, Zhe Liu, Yang Qi, Lingxiao Liu, Kun Zhao, Zhenghuan Xue, Mengzhou
Published in
Journal of colloid and interface science
Triple-negative breast cancer (TNBC) is insensitive to conventional therapy due to its highly invasive nature resulting in poor therapeutic outcomes. Recent studies have shown multiple genes associated with ferroptosis in TNBC, suggesting an opportunity for ferroptosis-based treatment of TNBC. However, the efficiency of present ferroptosis agents f...
Yahyaoui, Ons
Ce travail de recherche a étudié l'effet des nanoparticules d'or sur le comportement des polymères sous rayonnements ionisants en atmosphère inerte. L'objectif était de développer des matériaux à forte émission gazeuse intégrables dans de nouveaux dosimètres miniatures, passifs, à lecture en temps réel et à longue distance. L’idée était initiale ét...
Lee, Sang Mo Kim, Hyoyong Li, Pei Park, Hyun Gyu
Published in
Biosensors & bioelectronics
We herein developed a label-free and washing-free method to detect biological thiols (biothiols) on a personal glucose meter (PGM) utilizing the intrinsic glucose oxidase (GOx)-mimicking activity of gold nanoparticles (AuNPs). By focusing on the fact that this activity could be diminished by target biothiols through their binding onto the AuNP surf...
Moro, Sean
De nos jours, l’apparition de cellules tumorales du poumon résistantes aux traitements par radiothérapie représente un défi clinique majeur. Il a été montré que la déprotection des télomères sensibilise les cellules cancéreuses à la radiothérapie. L'un des principaux acteurs de la protection télomérique est la protéine TRF2 et une baisse de l’expre...
Queiroz, Suélio M Veriato, Thaís S Raniero, Leandro Castilho, Maiara L
Published in
Radiological physics and technology
The utilization of contrast agents in magnetic resonance imaging (MRI) has become increasingly important in clinical diagnosis. However, the low diagnostic specificity of this technique is a limiting factor for the early detection of tumors. To develop a new contrast agent with a specific target for early stage tumors, we present the synthesis and ...
Halmagyi, Tibor
Poly(ferrocenylsilanes) (PFSs) consist of a main chain made of alternating ferrocene and silane units, generally obtained via the ring-opening polymerization of ferrocenophane precursors. The ferrocene gives the polymer redox-active properties, whereas the side chains of the silane unit can be modified in post-polymerization procedures, giving grea...
Pundir, Meenakshi Lobanova, Liubov Papagerakis, Silvana Chen, Xiongbiao Papagerakis, Petros
Published in
Analytica chimica acta
Salivary melatonin is a clinically used biomarker for diagnosing circadian rhythm sleep disorders. Current melatonin detection assays are complex, expensive, and in many cases do not adequately measure low levels of salivary melatonin. Precisely measuring melatonin levels at multiple time points is crucial for determining dim light melatonin onset ...
Groysbeck, Nadja Ory, Stéphane Hanss, Victor Eltsov, Mikhael Schultz, Patrick Zuber, Guy
Despite advances in Electron Microscopy (EM) that enable to image protein assemblies within vitreous sections of cells at nearly atomic resolution, labelling is still necessary to locate small proteins or rare complexes. Gold immunolabelling has been used for decades to localise specific proteins within cellular sections. However, current gold part...
Elfiky, Abdo A Ibrahim, Ibrahim M Elghareib, Ahmed M Bashandy, Yousef S Samir, Ahmed Hamdy, Mayar M Kamal, Rana T Amin, Fatma G Elkaramany, Yomna Rashad, Anan M
...
Published in
Computers in biology and medicine
Gold nanoparticles (Au-NPs) have been used for a long time to target cancer cells. Different modalities have been suggested to utilize Au-NPs in cancer patients. We construct both normal and cancer cell membranes to simulate the Au-NP entry to understand better how it can penetrate the cancer cell membrane. We use molecular dynamics simulation (MDS...
Gao, Cheng Tang, Mian Lee, Simon M. Y. Wang, Ruibing
Published in
Bio-protocol
Cell-based carrier exhibits inherent advantages as the next generation of drug delivery system, namely high biocompatibility and physiological function. Current cell-based carriers are constructed via direct payload internalization or conjugation between cell and payload. However, the cells involved in these strategies must be firstly extracted fro...
