The Aromatic Cope Rearrangement (ArCopeR) is a highly challenging chemical reaction under thermal conditions, primarily attributed to the loss of aromaticity during the initial [3,3]-sigmatropic step of the process. Such rare transformation typically requires high temperatures and specially engineered 1,5-hexadiene scaffolds, making it impractical ...
International audience
Successful integration of point-of-care testing (POCT) into clinical settings requires improved assay sensitivity and precision to match laboratory standards. Here, we show how innovations in amplified biosensing, imaging, and data processing, coupled with deep learning, can help improve POCT. To demonstrate the performance of our approach, we pres...
BACKGROUND: Malaria is a major disease burden in Ethiopia. Migration can influence malaria transmission dynamics, with individuals relocating from malaria-free highland regions to malarious lowlands potentially facing elevated risks of contracting malaria. Migrants may find it difficult to protect themselves against malaria and have limited access ...
Cysteine is the most reactive naturally occurring amino acid due to the presence of a free thiol, presenting a tantalizing handle for covalent modification of peptides/proteins. Although many mass spectrometry experiments could benefit from site-specific modification of Cys, the utility of direct arylation has not been thoroughly explored. Recently...
Developing a desirable ethanol dehydrogenation process necessitates a highly efficient and selective catalyst with low cost. Herein, we show that the "complex active site" consisting of atomically dispersed Au atoms with the neighboring oxygen vacancies (Vo) and undercoordinated cation on oxide supports can be prepared and display unique catalytic ...
Monolayer protected metal clusters comprise a rich class of molecular systems and are promising candidate materials for a variety of applications. While a growing number of protected nanoclusters have been synthesized and characterized in crystalline forms, their dynamical behavior in solution, including prenucleation cluster formation, is not well...
Acknowledgements: RB, GL and SA thank the PhD school “Molecular Genetics, Biotechnologies and Experimental Medicine” in the University of Brescia, for supporting RB throughout her PhD studies. The Italian Ministry of University and Research (PRIN 2017 program 2017A4XRCA_003) is acknowledged for funding. AB is grateful to the Michael J. Fox Foundati...
Developing new low modulus structures is important for reducing the risk of aseptic loosening during loading of implant materials. However, an alloy that may also confer some advantage at preventing septic loosening could dramatically improve the outcomes for patients. Nevertheless, the predictive power of current models remains limited to common a...
Les polyoxométallates (POM) sont des oxydes moléculaires anioniques constitués de métaux à hauts degré d'oxydation qui possèdent de nombreuses propriétés dont des activités biomédicales, notamment une activité antitumorale qui peut être grandement améliorée en les fonctionnalisant avec des bisphosphonates (BP). Cette thèse explore l'utilisation de ...
