Baugh, Alexander T Gray-Gaillard, Sophie L
Published in
General and comparative endocrinology
Conventional methods for sampling hormones often preclude strong inference experimental designs, including repeated measures of both hormones and behavior and balanced or simultaneous designs for hormone-behavior sampling. In amphibians there is an opportunity to non-invasively and repeatedly sample excreted steroids in the water. We examined testo...
Marbouti, Ladan Zahmatkesh, Maryam Riahi, Esmail Shafiee Sabet, Mahdi
Published in
Molecular and cellular endocrinology
The 17β-estradiol (E2) enhances hippocampal dendritic spine synapses, facilitates learning processes, and exerts neuroprotection. Brain estrogen decline has been reported in Alzheimer's disease. The role of GnRH in modulating steroid biosynthesis convinced us to examine whether hippocampal GnRH administration could enhance the local E2 levels and o...
Esparza, Lourdes A Terasaka, Tomohiro Lawson, Mark A Kauffman, Alexander S
Published in
Endocrinology
Androgens can affect the reproductive axis of both sexes. In healthy women, as in men, elevated exogenous androgens decrease gonad function and lower gonadotropin levels; such circumstances occur with anabolic steroid abuse or in transgender men (genetic XX individuals) taking androgen supplements. The neuroendocrine mechanisms by which endogenous ...
Ohga, Hirofumi Matsuyama, Michiya
Published in
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology
Leptin directly influences gonadotropin (GTH) secretion from female pituitary cells in vitro and is a key signal at the onset of puberty in female chub mackerel (Scomber japonicus). Here, we investigated whether leptin also influences GTH secretion in male chub mackerel. The addition of 1 nM homologous recombinant leptin to pre-pubertal male pituit...
Calcaterra, Valeria De Filippo, Gianpaolo Albertini, Riccardo Rendina, Domenico Messini, Beatrice Monti, Claudio Maria Bozzola, Elena Villani, Alberto Bozzola, Mauro
Published in
Journal of Pediatric Endocrinology and Metabolism
Objectives Treatment of central precocious puberty (CPP) is based on administration of GnRH agonists in order to suppress hypothalamic-pituitary-gonadal axis and thus induce the stabilization or regression of pubertal development. Our aim was to determine whether the single basal serum LH and/or FSH concentration could be an effective tool to asses...
Cedeño, Andrés Tríbulo, Andrés Tríbulo, Ricardo J Andrada, Salvador Mapletoft, Reuben J Bó, Gabriel A
Published in
Theriogenology
Two experiments were designed to determine the effect of expression of estrus or GnRH treatment on pregnancies per embryo transfer (P/ET) and pregnancy losses in beef recipients that were synchronized with estradiol/progesterone based protocols for fixed-time embryo transfer (FTET). Experiment 1 evaluated the effect of expression of estrus and GnRH...
Yip, Siew Hoong Campos, Pauline Liu, Xinhuai Porteous, Robert Herbison, Allan E
Published in
Endocrinology
The neural mechanisms generating pulsatile GnRH release from the median eminence (ME) remain unclear. Studies undertaken in the mouse demonstrate that GnRH neurons extend projections to the ME that have properties of both dendrites and axons, termed "dendrons", and that the kisspeptin neuron pulse generator targets these distal dendrons to drive pu...
Wu, Hsien-Ming Chang, Hsun-Ming Leung, Peter C K
Published in
Frontiers in neuroendocrinology
Extra-hypothalamic GnRH and extra-pituitary GnRH receptors exist in multiple human reproductive tissues, including the ovary, endometrium and myometrium. Recently, new analogs (agonists and antagonists) and modes of GnRH have been developed for clinical application during controlled ovarian hyperstimulation for assisted reproductive technology (ART...
Bedenbaugh, M N Bowdridge, E C Hileman, S M
Published in
Domestic animal endocrinology
Puberty is the process whereby an individual acquires the ability to reproduce, and the attainment of puberty in a timely manner is critical for both humans and livestock. For livestock, the initiation of puberty at the appropriate time aids in increasing lifetime productivity, thus maximizing profitability for producers. For humans, particularly f...
Maione, Luigi Naulé, Lydie Kaiser, Ursula B
Published in
Current opinion in endocrine and metabolic research
Makorin RING finger protein 3 (MKRN3) is a key inhibitor of the hypothalamic-pituitary-gonadal axis. Loss-of-function mutations in MKRN3 cause familial and sporadic central precocious puberty (CPP), while polymorphisms are associated with age at menarche. To date, 115 patients with CPP carrying MKRN3 mutations have been described, harboring 48 diff...
