Gu, Wen Yang, Min Bi, Qian Zeng, Lin-Xi Wang, Xi Dong, Jin-Cai Li, Feng-Jiao Yang, Xing-Xin Li, Jing-Ping Yu, Jie
...
Published in
BMC Complementary Medicine and Therapies
BackgroundThe incidence of insulin resistance (IR) has rapidly increased worldwide over the last 20 years, no perfect solution has yet been identified. Finding new therapeutic drugs will help improve this situation. As a traditional Chinese medicine, PPM (processed Polygonum multiflorum) has widely been used in the clinic. Recently, other clinical ...
Matsudaira, Takashi Terada, Tatsuhiro Obi, Tomokazu Yokokura, Masamichi Takahashi, Yukitoshi Ouchi, Yasuomi
Published in
EJNMMI Research
BackgroundFunctional somatic syndrome (FSS) is a disorder characterized by clusters of medically unexplained symptoms. Some women suffer from persistent FSS after human papillomavirus (HPV) vaccination. However, a causal relationship has not been established, and the pathophysiology of FSS remains elusive. Here, we aimed to identify the brain regio...
Wang, Lin Chen, Hao Wang, Lingling Song, Linsheng
Published in
Developmental and comparative immunology
A robust immune response against invading pathogens greatly depends on the balance of metabolism, which could be vigorously modulated by insulin/IGF signaling (IIS) pathway in vertebrates. However, knowledge on the IIS pathway, especially the function of insulin-like peptides (ILPs) in invertebrates remained largely unknown. In the present study, a...
Zhang, Jinyi Juhl, Christian R. Hylten-Cavallius, Louise Salling-Olsen, Morten Linneberg, Allan Holst, Jens Juul Hansen, Torben Kanters, Jørgen K. Torekov, Signe S.
Published in
BMC Endocrine Disorders
BackgroundThe voltage-gated potassium channel Kv7.1 encoded by KCNQ1 is located in both cardiac myocytes and insulin producing beta cells. Loss-of-function mutations in KCNQ1 causes long QT syndrome along with glucose-stimulated hyperinsulinemia, increased C-peptide and postprandial hypoglycemia. The KCNE1 protein modulates Kv7.1 in cardiac myocyte...
Dubey, Sunil Kumar Lakshmi, K K Krishna, Kowthavarapu Venkata Agrawal, Mukta Singhvi, Gautam Saha, Ranendra Narayana Saraf, Swarnalat Saraf, Shailendra Shukla, Rahul Alexander, Amit
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Published in
Life sciences
Alzheimer's disease, a progressive neurodegenerative disorder, is one of the leading causes of death in the USA, along with cancer and cardiac disorders. AD is characterized by various neurological factors like amyloid plaques, tau hyperphosphorylation, mitochondrial dysfunction, acetylcholine deficiency, etc. Together, impaired insulin signaling i...
Yin, JianXing Shi, ZhuMei Wei, WenJin Lu, Chenfei Wei, Yutian Yan, Wei Li, Rui Zhang, JunXia You, YongPing Wang, XieFeng
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Published in
Cancer Cell International
BackgroundGlucose metabolic reprogramming is a significant hallmark of malignant tumors including GBM. Previous studies suggest that microRNAs play key roles in modulating this process in GBM cells. miR-181b acts as a tumor suppressor miRNA in influencing glioma tumorigenesis. Our previous results showed that miR-181b was down-regulated in glioma c...
Bos, Maxime M. Noordam, Raymond Bennett, Kate Beekman, Marian Mook-Kanamori, Dennis O. Willems van Dijk, Ko Slagboom, P. Eline Lundstedt, Torbjörn Surowiec, Izabella van Heemst, Diana
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Published in
Metabolomics
IntroductionSeveral plasma metabolites have been associated with insulin resistance and type 2 diabetes mellitus.ObjectivesWe aimed to identify plasma metabolites associated with different indices of early disturbances in glucose metabolism and insulin sensitivity.MethodsThis cross-sectional study was conducted in a subsample of the Leiden Longevit...
Li, Haijie Lan, Jingqin Wang, Guihua Guo, Kaixuan Han, Caishun Li, Xiaolan Hu, Junbo Cao, Zhixin Luo, Xuelai
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundHistone lysine demethylase 4B (KDM4B) has been implicated in various pathological processes and human diseases. Glucose metabolism is the main pattern of energy supply in cells and its dysfunction is closely related to tumorigenesis. Recent study shows that KDM4B protects against obesity and metabolic dysfunction. We realized the signific...
Ahmed, Fozia Chehadé, Lucia Garneau, Léa Caron, Audrey Aguer, Céline
Published in
Molecular and cellular endocrinology
Bisphenol A (BPA) is an environmental pollutant that has been associated with adverse health effects including skeletal muscle insulin resistance, a major contributor to the pathogenesis of type 2 diabetes (T2D). Early mitochondrial dysfunction and oxidative stress are linked to impaired glucose metabolism in skeletal muscle. In this study, we inve...
Suh, Hoon Young Choi, Hongyoon Paeng, Jin Chul Cheon, Gi Jeong Chung, June-Key Kang, Keon Wook
Published in
BMC Cancer
BackgroundThe principle of loss of iodine uptake and increased glucose metabolism according to dedifferentiation of thyroid cancer is clinically assessed by imaging. Though these biological properties are widely applied to appropriate iodine therapy, the understanding of the genomic background of this principle is still lacking. We investigated the...
