Suzuki, Kenta Kawai, Nobuyuki Ogawa, Tomoya Miyake, Keisuke Shinomiya, Aya Yamamoto, Yuka Nishiyama, Yoshihiro Tamiya, Takashi
Published in
EJNMMI Research
BackgroundTumor hypoxia and glycolysis have been recognized as determinant factors characterizing tumor aggressiveness in malignant gliomas. To clarify in vivo hypoxia and glucose metabolism in relation to isocitrate dehydrogenase (IDH) mutation and chromosome 1p and 19q (1p/19q) codeletion status, we retrospectively analyzed hypoxia as assessed by...
Zapater, Joseph L. Lednovich, Kristen R. Layden, Brian T.
Published in
Current Diabetes Reports
Purpose of ReviewGestational diabetes mellitus (GDM) is a common pregnancy complication conferring an increased risk to the individual of developing type 2 diabetes. As such, a thorough understanding of the pathophysiology of GDM is warranted. Hexokinase domain containing protein-1 (HKDC1) is a recently discovered protein containing hexokinase acti...
Nakagawa, Tomohito Tsuka, Shintaro Aonuma, Fumiko Nodai, Tomotaka Munemasa, Takashi Tamura, Akiko Mukaibo, Taro Kondo, Yusuke Masaki, Chihiro Hosokawa, Ryuji
...
Published in
Journal of prosthodontic research
In this study, we aimed to investigate the effect of glucose metabolism on bone healing after tooth extraction in an osteoporosis rat model administered zoledronic acid (ZA) and dexamethasone (DX). In total, 24 male Wistar rats (4 weeks old) were randomly assigned to four groups: Control (subcutaneous physiological saline), ZD (subcutaneous ZA and ...
Tan, Hui-Lan Guan, Xiao-Hui Hu, Min Wu, Jie Li, Rong-Zhen Wang, Ling-Fang Huang, Hou-Da Yu, Zhen-Ping Wang, Xiao-Yu Xiao, Yun-Fei
...
Published in
Stem Cell Research & Therapy
BackgroundObesity is a metabolic disorder syndrome characterized by excessive fat accumulation that is related to many diseases. Human amniotic mesenchymal stem cells (hAMSCs) have a great potential for cell-based therapy due to their characteristics such as pluripotency, low immunogenicity, no tumorigenicity, potent paracrine effects, and no ethic...
D'Alessandro, Angelo Howie, Heather L Hay, Ariel M Dziewulska, Karolina H Brown, Benjamin C Wither, Matthew J Karafin, Matthew Stone, Elizabeth F Spitalnik, Steven L Hod, Eldad A
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Published in
JCI insight
Deficiency of Glucose 6 phosphate dehydrogenase (G6PD) is the single most common enzymopathy, present in approximately 400 million humans (e.g., 5% of humans). Its prevalence is hypothesized to be due to conferring resistance to malaria. However, G6PD deficiency also results in hemolytic sequelae from oxidant stress. Moreover, G6PD deficiency is as...
Wang, Veronica A. James-Todd, Tamarra Hacker, Michele R. O’Brien, Karen E. Wylie, Blair J. Hauser, Russ Williams, Paige L. Bellavia, Andrea Quinn, Marlee McElrath, Thomas F.
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Published in
Environmental Health
BackgroundExposure to ionizing radiation has been associated with insulin resistance and type 2 diabetes. In light of recent work showing an association between ambient particulate matter (PM) gross β-activity and gestational diabetes mellitus (GDM) among pregnant women, we examined pregnancy glucose levels in relation to PM gross β-activity to bet...
Birru, Rahel L. Liang, Hai-Wei Farooq, Fouzia Bedi, Megha Feghali, Maisa Haggerty, Catherine L. Mendez, Dara D. Catov, Janet M. Ng, Carla A. Adibi, Jennifer J.
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Published in
Environmental Health
Per- and polyfluoroalkyl substances (PFAS) have been found to be associated with gestational diabetes mellitus (GDM) development, a maternal health disorder in pregnancy with negative effects that can extend beyond pregnancy. Studies that report on this association are difficult to summarize due to weak associations and wide confidence intervals. O...
Zhou, Hua Yu, Bing Sun, Jing Liu, Zuohua Chen, Hong Ge, Liangpeng Chen, Daiwen
Published in
Journal of Animal Science and Biotechnology
BackgroundPrevious studies have shown that exogenous short-chain fatty acids (SCFAs) introduction attenuated the body fat deposition in conventional mice and pigs. However, limited studies have evaluated the effects of exogenously introduced SCFAs on the lipid and glucose metabolism independently of the gut microbiota. This study was to investigate...
Yokote, Koutaro Yamashita, Shizuya Arai, Hidenori Araki, Eiichi Matsushita, Mitsunori Nojima, Toshiaki Suganami, Hideki Ishibashi, Shun
Published in
Cardiovascular Diabetology
BackgroundIncreased risk of cardiovascular events is associated not only with dyslipidemias, but also with abnormalities in glucose metabolism and liver function. This study uses pooled analysis to explore the in-depth effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator (SPPARMα) already known to decrease elev...
Mahrooz, Abdolkarim Muscogiuri, Giovanna Buzzetti, Raffaella Maddaloni, Ernesto
Published in
Endocrine
Angiotensin converting enzyme 2 (ACE2) is the door for SARS-CoV-2, expressed in critical metabolic tissues. So, it is rational that the new virus causes pleiotropic alterations in glucose metabolism, resulting in the complication of pre-existing diabetes's pathophysiology or creating new disease mechanisms. However, it seems that less attention has...
