Hernández-Mendoza, Héctor Álvarez-Loredo, Héctor Edmundo Romero-Guzmán, Elizabeth Teresita Gaytán-Hernández, Darío Chang-Rueda, Consuelo Martínez-Navarro, Israel Juárez-Flores, Bertha Irene Rios-Lugo, María Judith
Published in
Biological trace element research
In Mexico, few studies have analyzed the associations between toxic elements and metabolic diseases. In the present study, we analyzed the associations between serum arsenic (As), cadmium (Cd), and mercury (Hg) levels and body mass index (BMI) and fasting plasma glucose (FPG) in a Mexican adult population. Anthropometric data corresponding to 86 Me...
Diaz-Vegas, Alexis Norris, Dougall M Jall-Rogg, Sigrid Cooke, Kristen C Conway, Olivia J Shun-Shion, Amber S Duan, Xiaowen Potter, Meg van Gerwen, Julian Baird, Harry Jm
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Funder: Wellcome-MRC, Institute of Metabolic Science, Metabolic Research Laboratories, Imaging Core / Insulin-induced GLUT4 translocation to the plasma membrane in muscle and adipocytes is crucial for whole-body glucose homeostasis. Currently, GLUT4 trafficking assays rely on overexpression of tagged GLUT4. Here we describe a high-content imaging p...
Lehto, Alina Koch, Konrad Barnstorf-Brandes, Johanna Viel, Christian Fuchs, Marius Klein, Jochen
Published in
Neurochemical research
ß-Hydroxybutyrate (BHB) is a ketone body formed in high amounts during lipolysis and fasting. Ketone bodies and the ketogenic diet were suggested as neuroprotective agents in neurodegenerative disease. In the present work, we induced transient ischemia in mouse brain by unilaterally occluding the middle cerebral artery for 90 min. BHB (30 mg/kg), g...
Zhong, S Chèvre, R Castaño Mayan, D Corlianò, M Cochran, BJ Sem, KP van Dijk, TH Peng, J Tan, LJ Hartimath, SV
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10.1172/JCI152961 / The Journal of clinical investigation / 132 / 21 / e152961-
Sriranjan, Rouchelle Zhao, Tian Xiao Tarkin, Jason Hubsch, Annette Helmy, Joanna Vamvaka, Evangelia Jalaludeen, Navazh Bond, Simon Hoole, Stephen P Knott, Philip
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Funder: Medical Research Council / Funder: British Heart Foundation / Funder: National Institute for Health Research (NIHR) / INTRODUCTION: Inflammation plays a critical role in the pathogenesis of atherosclerosis, the leading cause of ischaemic heart disease (IHD). Studies in preclinical models have demonstrated that an increase in regulatory T ce...
Barzilay, Joshua I Tressel, William Biggs, Mary L Stein, Phyllis K Kizer, Jorge R Shitole, Sanyog G Bene-Alhasan, Yakubu Mukamal, Kenneth J
ObjectiveThe autonomic nervous system (ANS) innervates pancreatic endocrine cells, muscle, and liver, all of which participate in glucose metabolism. We tested whether measures of cardiovascular ANS function are independently associated with incident diabetes and annual change in fasting glucose (FG) levels as well as with insulin secretion and ins...
Singh, Kailash; Bricard, Orian; Haughton, Jeason; Bjorkqvist, Mikaela; Thorstensson, Moa; Luo, Zhengkang; Mascali, Loriana; Pasciuto, Emanuela; Mathieu, Chantal; 9139; Dooley, James; 61931;
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In type 1 diabetes, dysfunctional glucose regulation occurs due to the death of insulin-producing beta-cells in the pancreatic islets. Initiation of this process is caused by the inheritance of an adaptive immune system that is predisposed to responding to beta-cell antigens, most notably to insulin itself, coupled with unknown environmental insult...
Cappozzo, A McCrory, C Robinson, O Freni Sterrantino, A Sacerdote, C Krogh, V Panico, S Tumino, R Iacoviello, L Sieri, S
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Background: Recent evidence highlights the epidemiological value of blood DNA methylation (DNAm) as surrogate biomarker for exposure to risk factors for non-communicable diseases (NCD). DNAm surrogate of exposures predicts diseases and longevity better than self-reported or measured exposures in many cases. Consequently, disease prediction models b...
Lundahl, Mimmi LE Mitermite, Morgane Ryan, Dylan Gerard Case, Sarah Williams, Niamh C Yang, Ming Lynch, Roisin I Lagan, Eimear Lebre, Filipa M Gorman, Aoife L
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Funder: Trinity College Dublin / Macrophages are a highly adaptive population of innate immune cells. Polarization with IFNγ and LPS into the 'classically activated' M1 macrophage enhances pro-inflammatory and microbicidal responses, important for eradicating bacteria such as Mycobacterium tuberculosis. By contrast, 'alternatively activated' M2 mac...
Eimonte, Milda Eimantas, Nerijus Baranauskiene, Neringa Solianik, Rima Brazaitis, Marius
Published in
Cryobiology
Cold exposure-induced secretion of stress hormones activates cold-defense responses and mobilizes substrates for increased energy demands to fuel thermogenesis. However, it is unclear whether acute cold exposure-induced stress hormone response kinetics affect circulating lipid parameter kinetics. Therefore, we aimed to investigate the 2-day kinetic...
