Heparan sulfate (HS) is degraded in lysosome by a series of glycosidases. Before the glycosidases can act, the terminal glucosamine of HS must be acetylated by the integral lysosomal membrane enzyme heparan-α-glucosaminide N-acetyltransferase (HGSNAT). Mutations of HGSNAT cause HS accumulation and consequently mucopolysaccharidosis IIIC, a devastat...
Environmental microbes are an underexploited resource for the discovery of bioactive compounds. An integrated approach combining reversed-phase high-performance liquid chromatography and high-resolution tandem mass spectrometry with the use of molecular networks was applied to annotate novel chemical structures with potential antimicrobial activiti...
Published in The journals of gerontology. Series A, Biological sciences and medical sciences
We investigated the associations between habitual use of glucosamine and incident dementia and Parkinson's disease in a population-based cohort. Using the UK Biobank data, we included around 0.29 million middle- to old-aged participants free of dementia or Parkinson's disease at baseline. Glucosamine supplementation was measured by questionnaire at...
Published in Molecular biology reports
The skeleton is a living organ that undergoes constant changes, including bone formation and resorption. It is affected by various diseases, such as osteoporosis, osteopenia, and osteomalacia. Nowadays, several methods are applied to protect bone health, including the use of hormonal and non-hormonal medications and supplements. However, certain dr...
Published in Life sciences
Circadian rhythms are closely linked to the metabolic network through circadian feedback regulation. The hexosamine biosynthetic pathway (HBP) is a branch of glucose metabolism that affects circadian rhythms through the O-linked N-acetylglucosamine modification (O-GlcNAcylation) of clock proteins. Here, we found out that, among the downstream metab...
Published in World Journal of Orthopedics
BACKGROUND Oral treatment of glucosamine (GA) combined with chondroitin sulfate (CS) was reportedly effective for pain relief and function improvement in osteoarthritis patients with moderate to severe knee pain in clinical trials. While the effectiveness of GA and CS on both clinical and radiological findings has been demonstrated, only a few high...
Published in Applied biochemistry and biotechnology
The conventional production of chitosan from crustaceans has many limitations. An attempt was made to optimize chitosan production from fungi. Soil fungi were isolated, identified, and screened for high glucosamine content. Among the fungal isolates tested, Cunninghamella echinulata showed high glucosamine content. The biomass production of C. echi...
Published in Journal of psychosomatic research
To investigate the relationship between history of anti-inflammatory medication use and delirium risk, as well as long-term mortality. In this retrospective cohort study, subjects recruited between January 2016 and March 2020 were analyzed. Information about anti-inflammatory medication use history including aspirin, NSAIDs, glucosamine, and other ...
Published in Heliyon
Background Glucosamine and N-acetyl-glucosamine (NAG) are amino sugars found in human extracellular matrix with previously described anti-inflammatory effects. Despite mixed results from clinical studies, these molecules have been used extensively in supplements. Objective We investigated the anti-inflammatory properties of two synthesized derivati...
Published in Nutrition & Metabolism
Background To investigate the ameliorative effects of glucosamine (GS), chondroitin sulphate (CS) and glucosamine plus chondroitin sulphate (GC) on rheumatoid arthritis (RA) in rats, and to explore the mechanism of GS, CS and GC in improving RA based on the gut microbiota. Methods RA rat models were effectively developed 14 days after CFA injection...
