Zhu, Wen Yang, Feng Cai, Xiaofang Zhang, Wen Zhang, Jingsi Cai, Min Li, Xiangting Xiang, Jun Cai, Dingfang
Published in
Naunyn-Schmiedeberg's archives of pharmacology
Psychiatric diseases and metabolic disorders frequently cooccur, yet the mechanisms underlying this interaction remain unknown. The aim of this study was to determine the role of glucocorticoid receptor (GR) phosphorylation in the comorbidity of metabolic and psychiatric disorders. Neonatal Sprague-Dawley rats were subcutaneously injected with mono...
Krause, Jesse S Pérez, Jonathan H Reid, Angus M A Cheah, Jeffrey Bishop, Valerie Wingfield, John C Meddle, Simone L
Published in
General and comparative endocrinology
Capture-restraint is often used to investigate the acute hypothalamic-pituitary-adrenal axis (HPA) response to stress in wild and captive animals through the production of glucocorticoids. Although this approach is useful for understanding changes in glucocorticoids, it overlooks potential changes in the complex regulatory systems associated with t...
Wepler, Martin Preuss, Jonathan M. Merz, Tamara McCook, Oscar Radermacher, Peter Tuckermann, Jan P. Vettorazzi, Sabine
Published in
Intensive Care Medicine Experimental
Glucocorticoids (GCs) are stress hormones that regulate developmental and physiological processes and are among the most potent anti-inflammatory drugs to suppress chronic and acute inflammation. GCs act through the glucocorticoid receptor (GR), a ubiquitously expressed ligand-activated transcription factor, which translocates into the nucleus and ...
Shimba, Akihiro Ikuta, Koichi
Published in
Seminars in immunopathology
Animals receive environmental stimuli from neural signals in order to produce hormones that control immune responses. Glucocorticoids (GCs) are a group of steroid hormones produced in the adrenal cortex and well-known mediators for the nervous and immune systems. GC secretion is induced by circadian rhythm and stress, and plasma GC levels are high ...
K V, Athira Wahul, Abhipradnya Bipin Soren, Kalyani Das, Tapatee Dey, Sandeep Samudrala, Pavan Kumar Kumar, Arvind Lahkar, Mangala Chakravarty, Sumana
Published in
Psychoneuroendocrinology
The present study explored the antidepressant potential of vorinostat (VOR) against chronic social defeat stress (CSDS) in mice. Since this model has the remarkable capacity to delineate the resilient and the defeated mice, we also looked for their molecular deviations. Defeated mice showed classical phenotypic alterations such as anhedonia, social...
Clarisse, Dorien Offner, Fritz De Bosscher, Karolien
Published in
Biochimica et biophysica acta. Reviews on cancer
Glucocorticoids are essential drugs in the treatment protocols of lymphoid malignancies. These steroidal hormones trigger apoptosis of the malignant cells by binding to the glucocorticoid receptor (GR), which is a member of the nuclear receptor superfamily. Long term glucocorticoid treatment is limited by two major problems: the development of gluc...
Meduri, Gianfranco Umberto Annane, Djillali Confalonieri, Marco Chrousos, George P. Rochwerg, Bram Busby, Amanda Ruaro, Barbara Meibohm, Bernd
Published in
Intensive Care Medicine
Current literature addressing the pharmacological principles guiding glucocorticoid (GC) administration in ARDS is scant. This paucity of information may have led to the heterogeneity of treatment protocols and misinterpretation of available findings. GCs are agonist compounds that bind to the GC receptor (GR) producing a pharmacological response. ...
Præstholm, Stine M. Correia, Catarina M. Grøntved, Lars
Published in
Frontiers in Endocrinology
Glucocorticoids (GCs) and the glucocorticoid receptor (GR) are important regulators of development, inflammation, stress response and metabolism, demonstrated in various diseases including Addison's disease, Cushing's syndrome and by the many side effects of prolonged clinical administration of GCs. These conditions include severe metabolic challen...
Willmer, Tarryn Goedecke, Julia H. Dias, Stephanie Louw, Johan Pheiffer, Carmen
Published in
Clinical Epigenetics
BackgroundDisruption of the hypothalamic–pituitary–adrenal (HPA) axis, a neuroendocrine system associated with the stress response, has been hypothesized to contribute to obesity development. This may be mediated through epigenetic modulation of HPA axis-regulatory genes in response to metabolic stressors. The aim of this study was to investigate a...
Adrienne McGinn, M. Edwards, Kimberly N. Edwards, Scott
Published in
Neurobiology of Pain
Alcohol use disorder (AUD) is a chronic, relapsing psychiatric disorder that is characterized by the emergence of negative affective states. The transition from recreational, limited intake to uncontrolled, escalated intake is proposed to involve a transition from positive to negative reinforcement mechanisms for seeking alcohol. Past work has iden...
