Li, Menglin Ren, Tiankun Lin, Miao Wang, Zhe Zhang, Jinlan
Published in
Journal of proteomics
Temozolomide (TMZ) is the first-line chemotherapeutic drug for glioblastoma treatment. It can induce O6-methylguanine DNA lesions, lead to prolonged G2-M arrest and ultimately cell death. However, the molecular response induced by TMZ has not been fully elucidated. In this study, by integrating quantitative proteomics and metabolomics, we identifie...
Aydin, Sonay Fatihoğlu, Erdem Koşar, Pınar Nercis Ergün, Elif
Published in
Egyptian Journal of Radiology and Nuclear Medicine
BackgroundMRI is successful in showing the anatomy of probable pathologies of the central nervous system. Although it may not be sufficient to reveal physiological and metabolic changes, advanced MRI techniques, such as perfusion and permeability MRI, are the key to overcoming these limitations. The aim of this study was to detect the efficacy of p...
Zeng, Fan Wang, Kuanyu Liu, Xiu Zhao, Zheng
Published in
Cell Communication and Signaling
BackgroundGliomas are the most common and malignant brain tumors. The standard therapy is surgery combined with radiotherapy, chemotherapy, and/or other comprehensive methods. However, the emergence of chemoresistance is the main obstacle in treatment and its mechanism is still unclear.MethodsWe firstly developed a multi-gene signature by integrate...
Liu, Fangkun Huang, Jing Liu, Xuming Cheng, Quan Luo, Chengke Liu, Zhixiong
Published in
Cancer Cell International
BackgroundCTLA-4 is a well-studied immune checkpoint protein that negatively regulates T cell-mediated immune responses. However, the expression of CTLA-4 in glioma and the effects of CTLA-4 on prognosis in patients with glioma have not yet been examined.MethodsWe investigated the protein level of CTLA-4 in human glioma samples, extracted genetic a...
Hormuth, David A. II Jarrett, Angela M. Yankeelov, Thomas E.
Published in
Radiation Oncology
BackgroundIntra-and inter-tumoral heterogeneity in growth dynamics and vascularity influence tumor response to radiation therapy. Quantitative imaging techniques capture these dynamics non-invasively, and these data can initialize and constrain predictive models of response on an individual basis.MethodsWe have developed a family of 10 biologically...
Ginet, Merwan Zaragori, Timothée Marie, Pierre-Yves Roch, Véronique Gauchotte, Guillaume Rech, Fabien Blonski, Marie Lamiral, Zohra Taillandier, Luc Imbert, Laetitia
...
Purpose: 18F-FDopa PET imaging of gliomas is routinely interpreted with standardized uptake value (SUV)-derived indices. This study aimed to determine the added value of dynamic 18F-FDopa PET parameters for predicting the molecular features of newly diagnosed gliomas.Methods: We retrospectively included 58 patients having undergone an 18F-FDopa PET...
Ding, Chenyu Wu, Zanyi You, Honghai Ge, Hongliang Zheng, Shufa Lin, Yuanxiang Wu, Xiyue Lin, Zhangya Kang, Dezhi
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundCircular RNA nuclear factor I X (circNFIX) has been reported to play an important role in glioma progression. However, the mechanism by which circNFIX participates in glioma progression remains poorly understood.MethodsGERIA online were used to analyze the abnormally expressed genes in glioma tissues. The expression levels of circNFIX, mi...
Yu, Xiaojun Hu, Chi Zhang, Wenfei Zhou, Jie Ding, Qianshan Sadiq, M. T. Fan, Zeming Yuan, Zhaohui Liu, Linbo
Published in
BMC Medical Imaging
BackgroundPrecise identification, discrimination and assessment of central nervous system (CNS) tumors is of critical importance to brain neoplasm treatment. Due to the complexity and limited resolutions of the existing diagnostic tools, however, it is difficult to identify the tumors and their boundaries precisely in clinical practice, and thus, t...
Ding, Ye He, Chuan Lu, Shan Wang, Xuanzhong Wang, Chongcheng Wang, Lei Zhang, Ji Piao, Meihua Chi, Guangfan Luo, Yinan
...
Published in
Cancer letters
Chromatinolysis refers to enzymatic degradation of nuclear DNA and is regarded as one of the crucial events leading to cell death. Mixed-lineage kinase domain-like protein (MLKL) has been identified as a key executor of necroptosis, but it remains unclear whether MLKL contributes to necroptosis via regulation of chromatinolysis. In this study, we f...
Perreault, Sébastien Larouche, Valérie Tabori, Uri Hawkin, Cynthia Lippé, Sarah Ellezam, Benjamin Décarie, Jean-Claude Théoret, Yves Métras, Marie-Élaine Sultan, Serge
...
Published in
BMC Cancer
BackgroundPediatric low-grade gliomas (PLGG) are the most frequent brain tumors in children. Up to 50% will be refractory to conventional chemotherapy. It is now known that the majority of PLGG have activation of the MAPK/ERK pathway. The same pathway is also activated in plexiform neurofibromas (PNs) which are low-grade tumors involving peripheral...
