Liu, Feng-Min Gao, Yu-fei Kong, Yanyan Guan, Yihui Zhang, Jinsen Li, Shuai-Hong Ye, Dan Wen, Wenyu Zuo, Chuantao Hua, Wei
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Published in
BMC Cancer
Background Non-invasive diagnosis of IDH1 mutation for gliomas has great clinical significance, and PET has natural advantage to detect metabolism, as IDH mutated gliomas share lower glucose consumption. Methods Clinical data of patients with gliomas and 18F-FDG PET were retrospectively reviewed. Receiver operating characteristic curve (ROC) analys...
Zheng, Kebin Xie, Haipeng Wu, Wensong Wen, Xichao Zeng, Zhaomu Shi, Yanfang
Published in
Cancer Cell International
BackgroundIncreasing studies have revealed that circular RNAs (CircRNAs) make great contributions to regulating tumor progression. Therefore, we intended to explore the expression characteristics, function, and related mechanisms of a novel type of circRNA, PIP5K1A, in glioma.MethodsFirstly, reverse transcription-polymerase chain reaction (RT-PCR) ...
Xu, Xiangdong Liu, Yang Li, Yan Chen, Huajian Zhang, Yuxuan Liu, Jie Deng, Shaokang Zheng, Yaofeng Sun, Xinlin Wang, Jihui
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Published in
Journal of Experimental & Clinical Cancer Research
BackgroundExosomes are membrane-bound extracellular vesicles of 40–150 nm in size, that are produced by many cell types, and play an important role in the maintenance of cellular homeostasis. Exosome secretion allows for the selective removal of harmful substances from cells. However, it remains unclear whether this process also takes place in glio...
Berro, David Hassanein Herbet, Guillaume Duffau, Hugues
The sagittal stratum (SS) is a large sheet-like structure where major axonal fiber tracts cross, though its anatomical delineations are still debated. Here we investigated the poorly studied anatomo-functional organization of the right SS using direct electrical stimulation (DES) in patients undergoing wide-awake surgery for a cerebral glioma. Seve...
Saw, Phei Er Xu, Xiaoding Kang, Bo Ram Lee, Jungsul Lee, Yeo Song Kim, Chungyeul Kim, Hyungsin Kang, Shin-Hyuk Na, Yoo Jin Moon, Hong Joo
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Published in
Theranostics
Extra-domain B of fibronectin (EDB-FN) is an alternatively spliced form of fibronectin with high expression in the extracellular matrix of neovascularized tissues and malignant cancer cells. In this study, we evaluated the practicality of using EDB-FN as a biomarker and therapeutic target for malignant gliomas (MGs), representative intractable dise...
Munir, Sohbia Khan, Sohail Ahmed Hanif, Hina Khan, Maria
Published in
Pakistan Journal of Medical Sciences
Objective: To evaluate the diagnostic accuracy of magnetic resonance imaging (MRI) in detection of intra-axial gliomas in suspected cases keeping histopathology as gold standard. Methods: This cross-sectional study was conducted at Dow Institute of Radiology, DUHS from October 2017 - April 2018. Patients of either gender aged 30-70 years presenting...
Thust, Stefanie Micallef, Caroline Okuchi, Sachi Brandner, Sebastian Kumar, Atul Mankad, Kshitij Wastling, Stephen Mancini, Laura Jäger, Hans Rolf Shankar, Ananth
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Published in
Quantitative Imaging in Medicine and Surgery
Background To assess anatomical and quantitative diffusion-weighted MR imaging features in a recently classified lethal neoplasm, H3 K27M histone-mutant diffuse midline glioma [World Health Organization (WHO) IV]. Methods Fifteen untreated gliomas in teenagers and adults (median age 19, range, 14–64) with confirmed H3 K27M histone-mutant genotype w...
Zhang, Xianwen Zheng, Liaoyuan Duan, Jingfeng Li, Zongping Tang, Yufeng
Published in
Acta Epileptologica
BackgroundTo analyze the clinical features of brain tumor-related epilepsy (BTRE) and explore the factors influencing the identification of epilepsy-associated tumor (EAT), in order to advance the clinical understanding of BTRE and EAT.MethodsIntracranial tumor origin and location as well as the type of epilepsy were retrospectively reviewed in 153...
Tuncer, Mehmet Salih Salvati, Luca Francesco Grittner, Ulrike Hardt, Juliane Schilling, Ralph Bährend, Ina Silva, Luca Leandro Fekonja, Lucius S Faust, Katharina Vajkoczy, Peter
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Published in
NeuroImage. Clinical
Injury to major white matter pathways during language-area associated glioma surgery often leads to permanent loss of neurological function. The aim was to establish standardized tractography of language pathways as a predictor of language outcome in clinical neurosurgery. We prospectively analyzed 50 surgical cases of patients with left perisylvia...
Wang, Ziqian Dreyer, Felix Pulvermüller, Friedemann Ntemou, Effrosyni Vajkoczy, Peter Fekonja, Lucius S. Picht, Thomas
Published in
NeuroImage : Clinical
Repetitive TMS (rTMS) allows for non-invasive and transient disruption of local neuronal functioning. We used machine learning approaches to assess whether brain tumor patients can be accurately classified into aphasic and non-aphasic groups using their rTMS language mapping results as input features. Given that each tumor affects the subject-speci...