Stazi, Giulia Taglieri, Ludovica Nicolai, Alice Romanelli, Annalisa Fioravanti, Rossella Morrone, Stefania Sabatino, Manuela Ragno, Rino Taurone, Samanta Nebbioso, Marcella
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Published in
Clinical Epigenetics
BackgroundGlioblastoma (GBM) is the most lethal and aggressive malignant primary brain tumor in adults. After surgical resection of the tumor, the patient typically should be subjected to chemotherapy (temozolomide, TMZ) and concomitant radiotherapy. Since the TMZ treatment does not lead to complete remission and often develops resistance, the iden...
Yuan, Bo Shimada, Ryota Xu, Kang Han, Lingyu Si, Nan Zhao, Haiyu Bian, Baolin Hayashi, Hideki Okazaki, Mari Takagi, Norio
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Published in
Chemico-biological interactions
To provide novel insight into approaches designed to combat glioblastoma, the molecular details of the cytotoxicity of gamabufotalin, were investigated in the human glioblastoma cell line U-87. A dose-dependent cytotoxicity was observed in the cells, whereas no detectable toxicity was confirmed in mouse primary astrocytes. LDH leakage was only obse...
Soubéran, Aurélie Brustlein, Sophie Gouarné, Caroline Chasson, Lionel Tchoghandjian, Aurélie Malissen, Marie Rougon, Geneviève
Published in
Journal of Neuroinflammation
BackgroundTargeting angiogenesis has been and continues to be an attractive therapeutic modality in glioblastoma (GBM) patients. However, GBM rapidly becomes refractory to anti-VEGF therapies. Myeloid cell infiltration is an important determinant of tumor progression. Given that VEGF is a modulator of the innate immune response we sought to analyze...
Soni, Vikram S. Yanagihara, Ted K.
Published in
Cancer Imaging
Alternating electric fields have been successfully applied to cancer cells in-vitro to disrupt malignant progression and this antimitotic therapy has now been proven to be efficacious in Phase II and Phase III randomized clinical trials of patients with glioblastoma. With additional clinical trials ongoing in a number of other malignancies, there i...
Shi, Lin Liu, Huize Wang, Yifeng Chong, Yulong Wang, Jie Liu, Guanzheng Zhang, Xu Chen, Xiangyu Li, Huan Niu, Mingshan
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Published in
Cancer Cell International
BackgroundSwitch-associated protein 70 (SWAP-70) is a guanine nucleotide exchange factor that is involved in cytoskeletal rearrangement and regulation of migration and invasion of malignant tumors. However, the mechanism by which SWAP-70 regulates the migration and invasion of glioblastoma (GB) cells has not been fully elucidated.MethodsThis study ...
Tapfuma, Kudzanai Ian Uche-Okereafor, Nkemdinma Sebola, Tendani Edith Hussan, Raeesa Mekuto, Lukhanyo Makatini, Maya Mellisa Green, Ezekiel Mavumengwana, Vuyo
Published in
BMC Complementary and Alternative Medicine
BackgroundEndophytic fungi are a proven source of bioactive secondary metabolites that may provide lead compounds for novel drug discovery. In this study, crude extracts from fungal endophytes isolated from Datura stramonium were evaluated for cytotoxic activity on two human cancer cell lines.MethodsFungal endophytes were isolated from surface ster...
Dastmalchi, Farhad Karachi, Aida Yang, Changlin Azari, Hassan Sayour, Elias Joseph Dechkovskaia, Anjelika Vlasak, Alexander Loren Saia, Megan Ellen Lovaton, Rolando Eladio Mitchell, Duane Anthony
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Published in
Journal for ImmunoTherapy of Cancer
BackgroundDendritic cell (DC) vaccine efficacy is directly related to the efficiency of DC migration to the lymph node after delivery to the patient. We discovered that a naturally occurring metabolite, sarcosine, increases DC migration in human and murine cells resulting in significantly improved anti-tumor efficacy. We hypothesized that sarcosine...
Li, Yaomin Ren, Zhonglu Peng, Yuping Li, Kaishu Wang, Xiran Huang, Guanglong Qi, Songtao Liu, Yawei
Published in
BMC Medical Genomics
BackgroundPreviously developed classifications of glioma have provided enormous advantages for the diagnosis and treatment of glioma. Although the role of alternative splicing (AS) in cancer, especially in glioma, has been validated, a comprehensive analysis of AS in glioma has not yet been conducted. In this study, we aimed at classifying glioma b...
Choi, Bryan D. Yu, Xiaoling Castano, Ana P. Darr, Henia Henderson, Daniel B. Bouffard, Amanda A. Larson, Rebecca C. Scarfò, Irene Bailey, Stefanie R. Gerhard, Genevieve M.
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Published in
Journal for ImmunoTherapy of Cancer
Despite remarkable success in the treatment of hematological malignancies, CAR T-cell therapies for solid tumors have floundered, in large part due to local immune suppression and the effects of prolonged stimulation leading to T-cell dysfunction and exhaustion. One mechanism by which gliomas and other cancers can hamper CAR T cells is through surf...
Salvucci, Manuela Zakaria, Zaitun Carberry, Steven Tivnan, Amanda Seifert, Volker Kögel, Donat Murphy, Brona M. Prehn, Jochen H. M.
Published in
BMC Cancer
BackgroundThe evasion of apoptosis is a hallmark of cancer. Understanding this process holistically and overcoming apoptosis resistance is a goal of many research teams in order to develop better treatment options for cancer patients. Efforts are also ongoing to personalize the treatment of patients. Strategies to confirm the therapeutic efficacy o...
