Patel, Chirag B Beinat, Corinne Xie, Yuanyang Chang, Edwin Gambhir, Sanjiv S
Published in
Neoplasia (New York, N.Y.)
Despite the anti-proliferative and survival benefits from tumor treating fields (TTFields) in human glioblastoma (hGBM), little is known about the effects of this form of alternating electric fields therapy on the aberrant glycolysis of hGBM. [18F]FDG is the most common radiotracer in cancer metabolic imaging, but its utility in hGBM is impaired du...
Ferreira, W.A.S. Amorim, C.K.N. Burbano, R.R. Villacis, R.A.R. Marchi, F.A. Medina, T.S. Lima, M.M.C. de Oliveira, E.H.C. de
Cancer cell lines are widely used as in vitro models of tumorigenesis, facilitating fundamental discoveries in cancer biology and translational medicine. Currently, there are few options for glioblastoma (GBM) treatment and limited in vitro models with accurate genomic and transcriptomic characterization. Here, a detailed characterization of a new ...
Chang, Kai-Fu Huang, Xiao-Fan Chang, Jinghua Tsai Huang, Ya-Chih Weng, Jun-Cheng Tsai, Nu-Man
Published in
Cancer letters
Glioblastoma (GBM) is the most common and aggressive primary brain tumor with great invasiveness and resistance to chemotherapy, which presents a treatment challenge. In this study, we investigated the antitumor effect of Cedrol, a sesquiterpene alcohol isolated from Cedrus atlantica, against GBM cells in vitro and in vivo. Cedrol was found to pote...
Förnvik, Karolina Maddahi, Aida Liljedahl, Emma Osther, Kurt Salford, Leif G Redebrandt, Henrietta Nittby
Published in
Cancer treatment and research communications
Glioblastoma is the most common primary malignant brain tumor in adults. Previous studies have suggested that CRP (C-reactive protein) could serve as a biomarker candidate as well as a prognostic factor in glioblastoma patients, and we here further investigate its potential role. Publicly available datasets were used to compare gene expression betw...
Yarmishyn, Aliaksandr A. Yang, Yi-Ping Lu, Kai-Hsi Chen, Yi-Chen Chien, Yueh Chou, Shih-Jie Tsai, Ping-Hsing Ma, Hsin-I. Chien, Chian-Shiu Chen, Ming-Teh
...
Published in
Cancer Cell International
BackgroundGlioblastoma (GBM) is the most lethal brain tumor characterized by high morbidity and limited treatment options. Tumor malignancy is usually associated with the epigenetic marks, which coordinate gene expression to ascertain relevant phenotypes. One of such marks is m6A modification of RNA, whose functional effects are dependent on the YT...
Nordmann, Nathan J Michael, Alex P
Published in
Clinical neurology and neurosurgery
Radiodynamic therapy (RDT) involves administration of a radiosensitizing agent and its subsequent activation by ionizing radiation for destruction of neoplastic cells. A comprehensive evaluation of the literature was performed to review the history of RDT using porphyrins for solid tumors, the cellular mechanisms of action, immunomodulatory effects...
Xie, Tian Guo, Xiaoyu Duan, Hao He, Zhenqiang Mou, Yonggao
Published in
Clinical neurology and neurosurgery
We aimed to build a modified systemic inflammatory score(mSIS) based on preoperative albumin, fibrinogen, lactate dehydrogenase, and neutrophil-lymphocyte ratio in patients with high-grade glioma. Data of 318 patients with high-grade gliomas were retrospectively analyzed. The SIS was developed and its associations with clinicopathological features ...
Sha, Zhuang Song, Yunnong Wu, Yihao Sha, Pei Ye, Chengkun Fan, Guangwei Gao, Shangfeng Yu, Rutong
Published in
British journal of neurosurgery
To evaluate the value of texture analysis of routine MRI image in peritumoral edema of differentiating diagnosis between glioblastoma (GBM) and primary brain lymphoma (PBL). The MRI imaging data of 22 patients with glioblastoma and 21 patients with PBL who were hospitalized in our hospital from January 2010 to October 2018 were selected. All the pa...
Li, Ming Li, Guoping Kiyokawa, Juri Tirmizi, Zain Richardson, Leland G. Ning, Jianfang Das, Saumya Martuza, Robert L. Stemmer-Rachamimov, Anat Rabkin, Samuel D.
...
Published in
Acta Neuropathologica Communications
Cancer-associated fibroblasts (CAFs) are activated fibroblasts constituting the major stromal components in many types of cancer. CAFs contribute to hallmarks of cancer such as proliferation, invasion and immunosuppressive tumor microenvironment, and are associated with poor prognosis of patients with cancer. However, in glioblastoma (GBM), the mos...
Wang, Yibiao Cai, Renduan Wang, Pengcheng Huang, Chuixue Zhang, Chaocai Liu, Zhaohui
Published in
Clinical neurology and neurosurgery
To study the expression of FAM46A in glioblastoma (GBM) and analyze its significance in predicting the prognosis of patients. mRNA expression and clinical data of patients with GBM were retrieved from ONCOMINE databases and The Cancer Genome Atlas (TCGA) database. Immunohistochemistry was performed in a tissue microarray including 110 GBM cases and...
