Bezdieniezhnykh, N. Lykhova, A. Kozak, T. Zadvornyi, T. Borikun, T. Voronina, O. Lukianova, N.
Published in
BMC Pharmacology & Toxicology
Background The assessment of biosafety of pharmacologically active substances is crucial for determining the feasibility of their medical use. There are controversial issues regarding the use of substances of different origins as implants. Methods We have conducted the comprehensive studies to determine the in vivo toxicity and in vitro genotoxicit...
Qu, Minmin Xu, Hua Chen, Jia Xu, Bin Li, Zhi Ma, Bo Guo, Lei Ye, Qinong Xie, Jianwei
Published in
Toxicology in vitro : an international journal published in association with BIBRA
Aristolochic acids (AAs) are known to be the potent genotoxic carcinogens, of which aristolochic acid I (AAI) and aristolochic acid II (AAII) are the two representative compounds. As the carcinogenic risk of herbs containing AAs is a global health issue, quantitative evaluation of genotoxicity is needed for the risk assessment of AAs. γ-H2AX, which...
de Oliveira, Claudia Antonia Campos Rodr... Dos Santos Souto, Paulo Sérgio da Conceição Palheta, Dulcidéia de Oliveira Bahia, Marcelo da AraújoCunha, Lorena de Lourdes Souza Santos, Maria do Nascimento Medeiros Rodrigues, Tatian... Bentes, Bianca
Published in
Environmental science and pollution research international
Genotoxicity studies in coastal ecosystems have been a priority in Environmental Risk Assessment (ERA). This research aimed to study the genotoxicity by the micronucleus test and comet assay in two Brazilian Amazon estuaries (anthropized and control) using Plagioscion squamosissimus as a biomonitor. Blood samples were collected from 54 specimens. N...
de Lima e Silva, José Rodolfo de Lima, Anderson Rodrigues Balbino da Silva, Demétrios Lucas Rosa Filho, José Souto Adam, Mônica Lúcia
Published in
Environmental Monitoring and Assessment
Tourist occupancy in coastal environments threatens the stability of various coastal ecosystems and is thus a cause for concern for the environmental sector. As such, it is important to perform environmental monitoring in a way that analyses and quantifies the environmental impact of coastal ecosystems. Porto de Galinhas beach (Pernambuco – Brazil)...
Motafeghi, Farzaneh Mortazavi, Parham Salman Mahiny, Amir Hossein Abtahi, Mohammad Mehdi Shokrzadeh, Mohammad
Published in
Drug and chemical toxicology
Oxidative stress plays a prominent role in expanding toxicity and various diseases. This study investigated the potential protective effects of ginger (Zingiber officinale) rhizome extract and NAC on docetaxel induced genotoxicity and oxidative stress. The antioxidant power of NAC and ginger extract on the genetic toxicity induced by docetaxel was ...
Lyu, Ting Zhou, Hongyuan Wang, Yihui Jiang, Minyan Tao, Qian Chen, Juanlin Guo, Yitong Zhang, Qiuping Wang, Xu Guo, Xihan
...
Published in
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
Epidemiological studies have demonstrated that metformin (a cornerstone of diabetes treatment) has anticancer activity, but the underlying mechanism remains elusive. We aimed to investigate whether metformin elicits anticancer activity via increasing genotoxic stress, a state of increased genome damage that becomes tumor-suppressing if it goes beyo...
Verdon, Rachel Stone, Vicki Murphy, Fiona Christopher, Emily Johnston, Helinor Doak, Shareen Vogel, Ulla Haase, Andrea Kermanizadeh, Ali
Published in
Particle and Fibre Toxicology
The incorporation of nanomaterials (NMs) in consumer products has proven to be highly valuable in many sectors. Unfortunately, however, the same nano specific physicochemical properties, which make these material attractive, might also contribute to hazards for people exposed to these materials. The physicochemical properties of NMs will impact the...
Gökalp, Fulya Dilek Doğanlar, Oğuzhan Doğanlar, Zeynep Banu Güner, Utku
Published in
Drug and chemical toxicology
The aim of this study is to investigate the genotoxic effects of mixtures of five metals on zebrafish at two different concentrations; at the permissible maximum contamination levels in drinking water and irrigation waters. The drinking water limits are as follows: 300 µg/L for Aluminum (Al+3), 10 µg/L for Arsenic (As+3), 5 µg/L for Cadmium (Cd+2),...
Wei, Yu-Miao Li, Xiang Xu, Ming Abais, Justine M. Chen, Yang Riebling, Christopher R. Boini, Krishna M. Li, Pin-Lan Zhang, Yang
Published in
Cellular Physiology and Biochemistry
Background/Aims: In addition to their action of lowering blood cholesterol levels, statins modulate biological characteristics and functions of arterial myocytes such as viability, proliferation, apoptosis, survival and contraction. The present study tested whether simvastatin, as a prototype statin, enhances autophagy in coronary arterial myocytes...
Garofalo, Marion Payros, Delphine Oswald, Eric Nougayrède, Jean-Philippe Oswald, Isabelle P.
Humans are exposed to different contaminants including mycotoxins. Deoxynivalenol (DON), a potent ribosome inhibitor, is a highly prevalent mycotoxin in the food chain worldwide. Although DON is not genotoxic, we previously showed that it exacerbates the genotoxicity of colibactin, a DNA-crosslinking toxin produced by bacteria in the gut. In the pr...
