Background The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Interieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stra...
Plasma cell myeloma (PCM) is a complex and genetically heterogenous hematological malignancy involving clonal proliferation of plasma cells in bone marrow. It is the third most common hematolymphoid malignancy in the United States and primarily affects elderly people with a median onset age of 69 years and a survival duration ranging from a few mon...
Published in Human Genomics
Home to a culturally heterogeneous population, India is also a melting pot of genetic diversity. The population architecture characterized by multiple endogamous groups with specific marriage patterns, including the widely prevalent practice of consanguinity, not only makes the Indian population distinct from rest of the world but also provides a u...
Published in BMC Genomics
BackgroundGenomic evaluation is usually based on a set of markers assumed to be linked with causal mutations. Selection and precise management of major genes and the remaining polygenic component might be improved by including causal polymorphisms in the evaluation models. In this study, various methods involving a known mutation were used to estim...
bitstream/item/201952/1/DNA-methylation-and-functional-characterization-of-the-XIST-gene-during-in-vitro-early-embryo-development-in-cattle.pdf
Published in Clinical Sarcoma Research
BackgroundSarcomas are a rare, heterogeneous group of tumors with variable tendencies for aggressive behavior. Molecular markers for prognosis are needed to risk stratify patients and identify those who might benefit from more intensive therapeutic strategies.Patients and methodsWe analyzed somatic tumor genomic profiles and clinical outcomes of 15...
bitstream/item/201801/1/journal.pone.0218747.pdf
Published in Nature
How workflow tools can make your computational methods portable, maintainable, reproducible and shareable.
The amount of genetic variation discovered in human populations is growing rapidly leading to challenging computational tasks, such as variant calling. Standard methods for addressing this problem include read mapping, a computationally expensive procedure; thus, mapping-free tools have been proposed in recent years. These tools focus on isolated, ...
Published in Nature
Researchers rushing to apply powerful sequencing techniques to ancient-human remains must think harder about safeguarding, urge Keolu Fox and John Hawks. An archaeologist works at the osteological collection of the Anthropology National Museum in Mexico City
