Bovo, Samuele Schiavo, Giuseppina Ribani, Anisa Utzeri, Valerio J. Taurisano, Valeria Ballan, Mohamad Muñoz, Maria Alves, Estefania Araujo, Jose P. Bozzi, Riccardo
...
Published in
Scientific Reports
Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the varia...
Bart, Geneviève Fischer, Daniel Samoylenko, Anatoliy Zhyvolozhnyi, Artem Stehantsev, Pavlo Miinalainen, Ilkka Kaakinen, Mika Nurmi, Tuomas Singh, Prateek Kosamo, Susanna
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Published in
BMC Genomics
BackgroundThe human sweat is a mixture of secretions from three types of glands: eccrine, apocrine, and sebaceous. Eccrine glands open directly on the skin surface and produce high amounts of water-based fluid in response to heat, emotion, and physical activity, whereas the other glands produce oily fluids and waxy sebum. While most body fluids hav...
Rahimzadeh, Vasiliki Bartlett, Gillian Knoppers, Bartha Maria
Published in
BMC Medical Ethics
BackgroundThe highly sensitive nature of genomic and associated clinical data, coupled with the consent-related vulnerabilities of children together accentuate ethical, legal and social issues (ELSI) concerning data sharing. The Key Implications of Data Sharing (KIDS) framework was therefore developed to address a need for institutional guidance on...
Poon, Kok-Siong Siew-Chuan Koay, Evelyn
Published in
Nature
Letter to the Editor
Gonzalez, Guadalupe Gong, Shunwang Laponogov, Ivan Bronstein, Michael Veselkov, Kirill
Published in
Human Genomics
BackgroundRecent efforts in the field of nutritional science have allowed the discovery of disease-beating molecules within foods based on the commonality of bioactive food molecules to FDA-approved drugs. The pioneering work in this field used an unsupervised network propagation algorithm to learn the systemic-wide effect on the human interactome ...
Corboy, Greg Othman, Jad Lee, Linda Wei, Andrew Ivey, Adam Blombery, Piers Agarwal, Rishu Fong, Chun Brown, Anna Scott, Hamish
...
Published in
Pathology
Accurate classification of acute myeloid leukaemia (AML) has become increasingly reliant on molecular characterisation of this blood cancer. Throughout Australia and New Zealand massively parallel sequencing (MPS) is being adopted by diagnostic laboratories for the routine evaluation of patients with AML. This technology enables the surveying of ma...
Puentes-Osorio, Yolima Amariles, Pedro Calleja, Miguel Ángel Merino, Vicente Díaz-Coronado, Juan Camilo Taborda, Daniel
Published in
Autoimmunity Highlights
ObjectiveTo aid in the selection of the most suitable therapeutic option in patients with diagnosis of rheumatoid arthritis according to the phase of disease, through the review of articles that identify omics biological markers.MethodsA systematic review in PubMed/Medline databases was performed. We searched articles from August 2014 to September ...
Lyu, Xintong Wang, Ping Qiao, Qiao Jiang, Yuanjun
Published in
BMC Cancer
BackgroundThe tumour microenvironment (TME) not only plays a role during tumour progression and metastasis but also profoundly influences treatment efficacy. Environment-mediated drug resistance is a result of crosstalk between tumour cells and stroma. The presence of a “stromal exhaustion” response is suggested by the T cell exhaustion signature a...
Klim, Joanna Zielenkiewicz, Urszula Skoneczny, Marek Skoneczna, Adrianna Kurlandzka, Anna Kaczanowski, Szymon
Published in
BMC Ecology and Evolution
BackgroundThe impact of genetic interaction networks on evolution is a fundamental issue. Previous studies have demonstrated that the topology of the network is determined by the properties of the cellular machinery. Functionally related genes frequently interact with one another, and they establish modules, e.g., modules of protein complexes and b...
LOPES FILHO, J. H. SILVA, V. C. H. da SANTOS, J. C. dos DANTE, R. A. GERHARDT, I. R. YASSITEPE, J. E. de C. T. FERNANDES, F. R.
Present and future challenges of modern agriculture. Gene editing tools for precision crop breeding. Genome editing methodologies. Origin of the CRISPR/Cas technology. Overview of mechanisms and enzymes. Application of CRISPR in agriculture. Productivity increase. Quality improvement. Resistance to biotic factors. Resistance to abiotic factors. Acc...
