Andrei, Pietro Battuello, Paolo Grasso, Gaia Rovera, Emanuele Tesio, Nicolò Bardelli, Alberto
Published in
Seminars in cancer biology
Colorectal cancer (CRC) is one of the most common human malignancies accounting for approximately 10 % of worldwide cancer incidence and mortality. While early-stage CRC is mainly a preventable and curable disease, metastatic colorectal cancer (mCRC) remains an unmet clinical need. Moreover, about 25 % of CRC cases are diagnosed only at the metasta...
Rosenquist, Richard Cuppen, Edwin Buettner, Reinhard Caldas, Carlos Dreau, Helene Elemento, Olivier Frederix, Geert Grimmond, Sean Haferlach, Torsten Jobanputra, Vaidehi
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Published in
Seminars in cancer biology
Precision diagnostics is one of the two pillars of precision medicine. Sequencing efforts in the past decade have firmly established cancer as a primarily genetically driven disease. This concept is supported by therapeutic successes aimed at particular pathways that are perturbed by specific driver mutations in protein-coding domains and reflected...
Nolan, Ben O'Sullivan, Brian Golden, Aaron
Published in
Clinical and translational radiation oncology
The use of a 10 gene transcriptional signature as part of the GARD model has been shown to be predictive of radiotherapy benefit for a range of cancers, with the potential to determine an optimal overall dose per patient. We used publicly available RNA-seq transcriptomics data from a luminal B breast cancer patient and from 14 prostate cancer patie...
Blattner-Johnson, Mirjam Jones, David T W Pfaff, Elke
Published in
Seminars in cancer biology
Despite huge advances in the diagnosis and treatment of pediatric cancers over the past several decades, it remains one of the leading causes of death during childhood in developed countries. The development of new targeted treatments for these diseases has been hampered by two major factors. First, the extremely heterogeneous nature of the types o...
Tran, Thai Hoa Hunger, Stephen P
Published in
Seminars in cancer biology
Acute lymphoblastic leukemia (ALL) is the most common childhood cancer and constitutes approximately 25 % of cancer diagnoses among children under the age of 15 (Howlader et al., 2013) [1]. Overall, about half of ALL cases occur in children and adolescents and it is the most common acute leukemia until the early 20s, after which acute myeloid leuke...
Jäger, Natalie
Published in
Seminars in cancer biology
High-throughput molecular profiling of tumors is a fundamental aspect of precision oncology, enabling the identification of genomic alterations that can be targeted therapeutically. In this context, a patient is matched to a specific drug or therapy based on the tumor's underlying genetic driver events rather than the histologic classification. Thi...
Delnord, M Van Valckenborgh, Els Hebrant, Aline Antoniou, Aline Van Hoof, Wannes Waeytens, Anouk Van den Bulcke, M
Published in
Seminars in cancer biology
In 2016, Belgium launched the Next Generation Sequencing (NGS) Roadbook, consisting in 10 Actions, across the health care system, to facilitate the uptake of NGS in routine clinical practice. We compiled feedback on deployment of the NGS Roadbook from governmental stakeholders and beneficiaries: health policy makers, insurance providers, pathologis...
Chambwe, Nyasha Sayaman, Rosalyn W Hu, Donglei Huntsman, Scott analysis network, cancer genome Kemal, Anab Caesar-Johnson, Samantha Zenklusen, Jean C Ziv, Elad Beroukhim, Rameen
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Differential mRNA expression between ancestry groups can be explained by both genetic and environmental factors. We outline a computational workflow to determine the extent to which germline genetic variation explains cancer-specific molecular differences across ancestry groups. Using multi-omics datasets from The Cancer Genome Atlas (TCGA), we enu...
Swan, Tom Russell, Tanya L Staunton, Kyran M Field, Matt A Ritchie, Scott A Burkot, Thomas R
Published in
Parasites & vectors
Aedes albopictus is a highly invasive species and an important vector of dengue and chikungunya viruses. Indigenous to Southeast Asia, Ae. albopictus has successfully invaded every inhabited continent, except Antarctica, in the past 80 years. Vector surveillance and control at points of entry (PoE) is the most critical front line of defence against...
de Crécy-Lagard, Valérie Amorin de Hegedus, Rocio Arighi, Cecilia Babor, Jill Bateman, Alex Blaby, Ian Blaby-Haas, Crysten Bridge, Alan J Burley, Stephen K Cleveland, Stacey
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Funder: U.S. National Library of Medicine / Over the last 25 years, biology has entered the genomic era and is becoming a science of 'big data'. Most interpretations of genomic analyses rely on accurate functional annotations of the proteins encoded by more than 500 000 genomes sequenced to date. By different estimates, only half the predicted sequ...
