Sutera, Philip Song, Yang Van der Eecken, Kim Shetty, Amol C English, Keara Hodges, Theresa Chang, Jinhee Fonteyne, Valérie Rana, Zaker Ren, Lei
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Published in
European urology
In metastatic castration-sensitive prostate cancer (mCSPC), disease volume plays an integral role in guiding treatment recommendations, including selection of docetaxel therapy, metastasis-directed therapy, and radiation to the prostate. Although there are multiple definitions of disease volume, they have commonly been studied in the context of met...
Tesema, Birhanu Liu, Gui-Qiang Jiang, Xun-Ping
Published in
Animal biotechnology
To evaluate the efficacy of oral immunization with active kisspeptin DNA vaccine on the expression of hormone receptor mRNA. For this study, ten 56-day-old Hu breed ram lambs were randomly assigned to the treatment and control groups (n = 5). Treatment Experimental group received C500/pKS-asd and the control group received C500/pVAX-asd (aspartate-...
Mead, Elyse C Wang, Carol A Phung, Jason Fu, Joanna Yx Williams, Scott M Merialdi, Mario Jacobsson, Bo Lye, Stephen Menon, Ramkumar Pennell, Craig E
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Published in
Reproductive sciences (Thousand Oaks, Calif.)
Preterm birth (PTB), defined as the birth of a child before 37 completed weeks gestation, affects approximately 11% of live births and is the leading cause of death in children under 5 years. PTB is a complex disease with multiple risk factors including genetic variation. Much research has aimed to establish the biological mechanisms underlying PTB...
Grillova, Linda Cokelaer, Thomas Mariet, Jean-François Pipoli da Fonseca, Juliana Picardeau, Mathieu
BackgroundThe life-threatening pathogen Leptospira interrogans is the most common agent of leptospirosis, an emerging zoonotic disease. However, little is known about the strains that are currently circulating worldwide due to the fastidious nature of the bacteria and the difficulty to isolate cultures. In addition, the paucity of bacteria in blood...
Woodbury-Smith, Marc D'Abate, Lia Stavropoulos, Dimitri J Howe, Jennifer Drmic, Irene Hoang, Ny Zarrei, Mehdi Trost, Brett Iaboni, Alana Anagnostou, Evdokia
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Published in
Journal of medical genetics
We present genomic and phenotypic findings of a transgenerational family consisting of three male offspring, each with a maternally inherited distal 220 kb deletion at locus 16p11.2 (BP2-BP3). Genomic analysis of all family members was prompted by a diagnosis of autism spectrum disorder (ASD) in the eldest child, who also presented with a low body ...
Levi, Hagai Carmi, Shai Rosset, Saharon Yerushalmi, Rinat Zick, Aviad Yablonski-Peretz, Tamar Wang, Qin Bolla, Manjeet K Dennis, Joe Michailidou, Kyriaki
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Published in
Journal of medical genetics
Polygenic risk score (PRS), calculated based on genome-wide association studies (GWASs), can improve breast cancer (BC) risk assessment. To date, most BC GWASs have been performed in individuals of European (EUR) ancestry, and the generalisation of EUR-based PRS to other populations is a major challenge. In this study, we examined the performance o...
Garrison, McKinzie Jang, Yeongjun Bae, Taejeong Cherskov, Adriana Emery, Sarah Fasching, Liana Jones, Attila Moldovan, John Molitor, Cindy Pochareddy, Sirisha
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Somatic mosaicism is defined as an occurrence of two or more populations of cells having genomic sequences differing at given loci in an individual who is derived from a single zygote. It is a characteristic of multicellular organisms that plays a crucial role in normal development and disease. To study the nature and extent of somatic mosaicism in...
Faure, Roland Hilaire, Baptiste Lavenier, Dominique
Efficiently managing vast DNA datasets necessitates the development of highly effective sequence compression techniques to reduce storage and computational requirements. We propose here to explore the potential of a lossy compression technique, Mapping-friendly Sequence Reductions (MSRs).
Chaturvedi, Samridhi Marimuthu, Mohan Nguyen, Oanh Chumchim, Noravit Fairbairn, Colin Miller, Courtney Shaffer, H Whiteman, Noah Escalona, Merly Seligmann, William
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The California Pipevine Swallowtail Butterfly, Battus philenor hirsuta, and its host plant, the California Pipevine or Dutchmans Pipe, Aristolochia californica Torr., are an important California endemic species pair. While this species pair is an ideal system to study co-evolution, genomic resources for both are lacking. Here, we report a new, chro...
Herb, Brian Glover, Hannah Bhaduri, Aparna Colantuoni, Carlo Bale, Tracy Siletti, Kimberly Hodge, Rebecca Lein, Ed Doege, Claudia Ament, Seth
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The development and diversity of neuronal subtypes in the human hypothalamus has been insufficiently characterized. To address this, we integrated transcriptomic data from 241,096 cells (126,840 newly generated) in the prenatal and adult human hypothalamus to reveal a temporal trajectory from proliferative stem cell populations to mature hypothalam...