Muir, AGurung, ICehovin, ABazin, AVallenet, DPelicic, V
The bacterium Neisseria meningitidis causes life-threatening meningitis and sepsis. Here, we construct a complete collection of defined mutants in protein-coding genes of this organism, identifying all genes that are essential under laboratory conditions. The collection, named NeMeSys 2.0, consists of individual mutants in 1584 non-essential genes....
David, SophiaCohen, VictoriaReuter, SandraSheppard, Anna EGiani, TommasoParkhill, JulianRossolini, Gian MariaFeil, Edward JGrundmann, HajoAanensen, David M
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Hall, Matthew DHolden, Matthew TgSrisomang, PramotMahavanakul, WeeraWuthiekanun, VanapornLimmathurotsakul, DirekFountain, KayParkhill, JulianNickerson, Emma KPeacock, Sharon
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Methicillin-resistant Staphylococcus aureus (MRSA) transmission in the hospital setting has been a frequent subject of investigation using bacterial genomes, but previous approaches have not yet fully utilised the extra deductive power provided when multiple pathogen samples are acquired from each host. Here, we use a large dataset of MRSA sequence...
Of the ten human-restricted Neisseria species two, Neisseria meningitidis, and Neisseria gonorrhoeae, cause invasive disease: the other eight are carried asymptomatically in the pharynx, possibly modulating meningococcal and gonococcal infections. Consequently, characterizing their diversity is important for understanding the microbiome in health a...
