How science has shifted our sense of identity
Published in Nature
Biological advances have repeatedly changed who we think we are.
The role of haematological traits in risk of ischaemic stroke and its subtypes
This study was supported by a British Heart Foundation Programme grant (RG/16/4/32218) and the European Union’s Horizon 2020 research and innovation programme under grant agreement No 667375 (CoSTREAM). It also received infrastructural support from the Cambridge University Hospitals NIHR Biomedical Research Centre. This research was conducted using...
Darwin and Nature’s 150th anniversary
Published in Nature
Mutations in the SPTLC1 gene are a cause of amyotrophic lateral sclerosis that may be amenable to serine supplementation...
SPTLC1 encodes a critical subunit of serine palmitoyltransferase, the enzyme catalyzing the first and rate-limiting step in de novo sphingolipid biosynthesis, and mutations in this gene are known to cause hereditary sensory autonomic neuropathy, type 1A. Using exome sequencing, we identified a de novo variant in SPTLC1 resulting in a p.Ala20Ser ami...
Cancer: more genetic BRCA testing for men
Published in Nature
Genome-wide association studies of 74 plasma metabolites of German shepherd dogs reveal two metabolites associated with ...
...Published in Metabolomics
IntroductionGerman shepherd dogs (GSDs) are a popular breed affected by numerous disorders. Few studies have explored genetic variations that influence canine blood metabolite levels.ObjectivesTo investigate genetic variants affecting the natural metabolite variation in GSDs.MethodsA total of 82 healthy GSDs were genotyped on the Illumina CanineHD ...
Genome analysis and engineering of industrial lager brewing yeasts
Lager beer, also referred to as Pilsner, is the most popular alcoholic beverage in the world, with an annual consumption of almost 200 billion litres per year. To make lager beer, brewer’s wort is fermented with the yeast Saccharomyces pastorianus. This microorganism converts wort sugars into ethanol and contributes key flavour compounds to the bee...
Host susceptibility to severe influenza A virus infection
Published in Critical Care
Most people exposed to a new flu virus do not notice any symptoms. A small minority develops critical illness. Some of this extremely broad variation in susceptibility is explained by the size of the initial inoculum or the influenza exposure history of the individual; some is explained by generic host factors, such as frailty, that decrease resili...
Association Between aquaporin-1 and Endurance Performance: A Systematic Review
Published in Sports Medicine - Open
BackgroundThere is abundant and mounting information related to the molecular and biological structure and function of the Aquaporin-1 (AQP1) gene and the AQP1-Aquaporin channel. Regulation of water flow across cell membranes is essential for supporting inter- and intracellular fluid balance, which is critical for health and exercise performance. T...
Low-copy nuclear sequence data confirm complex patterns of farina evolution in notholaenid ferns (Pteridaceae)
© 2019 Elsevier Inc. Notholaenids are an unusual group of ferns that have adapted to, and diversified within, the deserts of Mexico and the southwestern United States. With approximately 40 species, this group is noted for being desiccation-tolerant and having “farina”—powdery exudates of lipophilic flavonoid aglycones—that occur on both the gameto...
