Cai, Xuan Dong, Jun Lu, Teng Zhi, Liqiang He, Xijing
Published in
Journal of Orthopaedic Surgery and Research
BackgroundOsteoporosis (OP) is a complex bone metabolism disorder characterized by the loss of bone minerals and an increased risk of bone fracture. A recent study reported the relationship of the macrophage erythroblast attacher gene (MAEA) with low bone mineral density in postmenopausal Japanese women. Our study aimed to investigate the associati...
Gómez, Juan Albaiceta, Guillermo M García-Clemente, Marta López-Larrea, Carlos Amado-Rodríguez, Laura Lopez-Alonso, Inés Hermida, Tamara Enriquez, Ana I Herrero, Pablo Melón, Santiago
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Published in
Gene
The Angiotensin system is implicated in the pathogenesis of COVID-19. First, ACE2 is the cellular receptor for SARS-CoV-2, and expression of the ACE2 gene could regulate the individuaĺs susceptibility to infection. In addition, the balance between ACE1 and ACE2 activity has been implicated in the pathogenesis of respiratory diseases and could play ...
Arayasongsak, Unchana Naka, Izumi Ohashi, Jun Patarapotikul, Jintana Nuchnoi, Pornlada Kalambaheti, Thareerat Sa-Ngasang, Areerat Chanama, Sumalee Chaorattanakawee, Suwanna
Published in
BMC Infectious Diseases
BackgroundDengue patients develop different disease severity ranging from mild (dengue fever [DF]) to severe forms (dengue hemorrhagic fever [DHF] and the fatal dengue shock syndrome [DSS]). Host genetics are considered to be one factor responsible for the severity of dengue outcomes. To identify genes associated with dengue severity that have not ...
Mahmoudi, Mahdi Aslani, Saeed Meguro, Akira Akhtari, Maryam Fatahi, Yousef Mizuki, Nobuhisa Shahram, Farhad
Published in
International reviews of immunology
Behçet's disease (BD) is a systemic and inflammatory disease, characterized mainly by recurrent oral and genital ulcers, eye involvement, and skin lesions. Although the exact etiopathogenesis of BD remains unrevealed, a bulk of studies have implicated the genetic contributing factors as critical players in disease predisposition. In countries along...
Karimian, Mohammad Behjati, Mohaddeseh Barati, Erfaneh Ehteram, Tayyebeh Karimian, Ali
Published in
Environmental science and pollution research international
Antioxidant enzymes such as glutathione S-transferases (GSTs) and cytochromes P450 (CYPs) are involved in the metabolism and detoxification of cytotoxic compounds, as well as the elimination of reactive oxygen species (ROS). Therefore, alterations in the structure of these enzymes could result in prolonged production of ROS with subsequent risk of ...
Seo, Jieun Byun, Min Soo Yi, Dahyun Lee, Jun Ho Jeon, So Yeon Shin, Seong A. Kim, Yu Kyeong Kang, Koung Mi Sohn, Chul-Ho Jung, Gijung
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Published in
Alzheimer's Research & Therapy
IntroductionAlthough the heritability of sporadic Alzheimer’s disease (AD) is estimated to be 60–80%, addressing the genetic contribution to AD risk still remains elusive. More specifically, it remains unclear whether genetic variants are able to affect neurodegenerative brain features that can be addressed by in vivo imaging techniques.MethodsTarg...
Zhuang, Zhenhuang Yang, Ruotong Wang, Wenxiu Qi, Lu Huang, Tao
Published in
Journal of Neuroinflammation
BackgroundGrowing evidence has shown that alterations in the gut microbiota composition were associated with a variety of neuropsychiatric conditions. However, whether such associations reflect causality remains unknown. We aimed to reveal the causal relationships among gut microbiota, metabolites, and neuropsychiatric disorders including Alzheimer...
Salhi, Mariem Tizaoui, Kalthoum Louhaichi, Sabrine Lahmar, Oussama Hamzaoui, Kamel Hamzaoui, Agnes
Published in
Cytokine
The interleukin-26 (IL-26), a member of the IL-10 family is one of the latest discovered cytokines which contributes in numerous chronic autoimmune and inflammatory disorders. In the current case-control study, we investigated the distribution of three IL-26 single nucleotide polymorphisms (SNPs) (rs7134599, rs2870946 & rs1558744) in 440 Tunisian a...
Lents, C A Lindo, A N Hileman, S M Nonneman, D J
Published in
Domestic animal endocrinology
The timing of pubertal attainment in gilts is a critical factor for pork production and is an early indicator of future reproductive potential. Puberty, defined as age at first standing estrus in the presence of a boar, is brought about by an escape from estrogen inhibition of the GnRH pulse generator, which allows for increasing LH pulses leading ...
Zhang, Yuhua Quick, Corbin Yu, Ketian Barbeira, Alvaro Luca, Francesca Pique-Regi, Roger Kyung Im, Hae Wen, Xiaoquan
Published in
Genome Biology
We propose a new computational framework, probabilistic transcriptome-wide association study (PTWAS), to investigate causal relationships between gene expressions and complex traits. PTWAS applies the established principles from instrumental variables analysis and takes advantage of probabilistic eQTL annotations to delineate and tackle the unique ...
