Mortazavi, S. A. R. Kaveh-Ahangar, K. Mortazavi, S. M. J. Firoozi, D. Haghani, M.
Published in
Journal of Biomedical Physics & Engineering
Neanderthal genes possibly gave modern human protection against viruses. However, a recent study revealed that that a long sequence of DNA that is inherited from our Neanderthal ancestors can be linked to severe COVID-19 infection and hospitalization. Substantial evidence now indicates that our genetic background may be involved in the transmissibi...
Lhermitte, B Blandin, A F Coca, A Guerin, E Durand, A Entz-Werlé, N
Published in
Neuro-Chirurgie
Medulloblastomas (MBs) account for 15% of brain tumors in children under the age of 15. To date, the overall 5-year survival rate for all children is only around 60%. Recent advances in cancer genomics have led to a fundamental change in medulloblastoma classification and is evolving along with the genomic discoveries, allowing to regularly reclass...
Yu, Timothy C Liu, Winnie L Brinck, Marcia S Davis, Jessica E Shek, Jeremy Bower, Grace Einav, Tal Insigne, Kimberly D Phillips, Rob Kosuri, Sriram
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A crucial step towards engineering biological systems is the ability to precisely tune the genetic response to environmental stimuli. In the case of Escherichia coli inducible promoters, our incomplete understanding of the relationship between sequence composition and gene expression hinders our ability to predictably control transcriptional respon...
Solares, Edwin A Tao, Yuan Long, Anthony D Gaut, Brandon S
BackgroundDespite marked recent improvements in long-read sequencing technology, the assembly of diploid genomes remains a difficult task. A major obstacle is distinguishing between alternative contigs that represent highly heterozygous regions. If primary and secondary contigs are not properly identified, the primary assembly will overrepresent bo...
Giannopoulos, Konstantinos Gazouli, Maria Chatzistefanou, Klio Bakouli, Anthi Moschos, Marilita M
Published in
Journal of Genomics
Central serous chorioretinopathy is characterized by neurosensory detachment of the central retina secondary to fluid leakage through the retinal pigment epithelium. Though it has an incidence of 9,9 per 100.000 in men and 1,7 per 100.000 in women, it is the fourth most common retinal disorder. Central serous chorioretinopathy patients present with...
KIRUNGU, Joy Nyangasi MAGWANGA, Richard Odongo SHIRAKU, Margaret Linyerera LU, Pu MEHARI, Teame Gereziher XU, Yuanchao HOU, Yuqing AGONG, Stephen Gaya ZHOU, Yun CAI, Xiaoyan
...
Published in
Journal of Cotton Research
BackgroundSegregation distortion (SD) is a common phenomenon among stable or segregating populations, and the principle behind it still puzzles many researchers. The F2:3 progenies developed from the wild cotton species of the D genomes were used to investigate the possible plant transcription factors within the segregation distortion regions (SDRs...
Mukai, Yosuke Ueno, Hideki
Published in
Cancer science
Approximately one in two Japanese people are estimated to be diagnosed with cancer during their lifetime. Cancer still remains the leading cause of death in Japan; therefore, the government of Japan has decided to develop a better cancer control policy and launched the Cancer Genomic Medicine (CGM) program. The Ministry of Health, Labour and Welfar...
Fang, H-J Liu, B-P
Published in
Herz
A meta-analysis was performed to assess the prevalence of TTN mutations in patients with dilated cardiomyopathy (DCM). Prevalence point estimates and 95% confidence intervals were computed using the logit transformation formula. The prevalence of TTN mutations in patient with DCM, familial dilated cardiomyopathy (FDCM), and sporadic dilated cardiom...
Spinler, Kyle Bajaj, Jeevisha Ito, Takahiro Zimdahl, Bryan Hamilton, Michael Ahmadi, Armin Koechlein, Claire S Lytle, Nikki Kwon, Hyog Young Anower-E-Khuda, Ferdous
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Intratumoral heterogeneity is a common feature of many myeloid leukemias and a significant reason for treatment failure and relapse. Thus, identifying the cells responsible for residual disease and leukemia re-growth is critical to better understanding how they are regulated. Here, we show that a knock-in reporter mouse for the stem cell gene Musas...
Kong, Sung Hye Yoon, Ji Won Kim, Jung Hee Park, JooYong Choi, Jiyeob Lee, Ji Hyun Hong, A Ram Cho, Nam H. Shin, Chan Soo
Published in
Endocrinology and Metabolism
Background As the genetic variants of trabecular bone microarchitecture are not well-understood, we performed a genome-wide association study to identify genetic determinants of bone microarchitecture analyzed by trabecular bone score (TBS). Methods TBS-associated genes were discovered in the Ansung cohort (discovery cohort), a community-based rura...
