Hu, Ben-Shun Tang, Tian Jia, Jun-Li Xie, Bi-Chen Wu, Tie-Long Sheng, Ying-Yue Xue, Yu-Zheng Tang, Hua-Min
Published in
Cancer Cell International
Background CD137 is a target for tumor immunotherapy. However, the role of CD137 in gastric cancer (GC), especially in inducing GC cell apoptosis, has not been studied. Methods Foxp3+ and CD8+ T cells in GCs were investigated using immunohistochemistry (IHC). CD137 expression in GCs was detected using flow cytometry, IHC and immunofluorescence (IF)...
Fujimori, Daisuke Kinoshita, Jun Yamaguchi, Takahisa Nakamura, Yusuke Gunjigake, Katsuya Ohama, Takashi Sato, Koichi Yamamoto, Masami Tsukamoto, Tetsuya Nomura, Sachiyo
...
Published in
BMC Cancer
Background Peritoneal metastasis (PM) in gastric cancer (GC) is characterized by diffusely infiltrating and proliferating cancer cells accompanied by extensive stromal fibrosis in the peritoneal space. The prognosis of GC with PM is still poor regardless of the various current treatments. In order to elucidate the cause of difficulties in PM treatm...
Arigami, Takaaki Matsushita, Daisuke Okubo, Keishi Tanaka, Takako Sasaki, Ken Noda, Masahiro Kita, Yoshiaki Mori, Shinichiro Tsuruda, Yusuke Kurahara, Hiroshi
...
Published in
Surgical Case Reports
Background The prognosis of patients with recurrent gastric cancer is poor despite chemotherapy being clinically recommended as the first therapeutic strategy. Recent clinical trials have established the clinical utility of nivolumab in the third-line treatment of such patients. Immune-related adverse events (irAE) have been focused as a promising ...
Guo, Xufeng Li, Ming
Published in
Cancer Cell International
BackgroundGastric cancer (GC) is one of the most common malignancies around the world. Recently, the role of long non-coding RNA (lncRNA) in cancer biology has become a hot research topic. This work aimed to explore the biological function and underlying mechanism of LINC01089 in GC.MethodsQuantitative real-time polymerase chain reaction (qRT-PCR) ...
Zhou, Wenjuan Ma, Liying Yang, Jing Qiao, Hui Li, Lingyu Guo, Qian Ma, Jinlian Zhao, Lijuan Wang, Junwei Jiang, Guozhong
...
Published in
Cell Death & Disease
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Zhao, Chuanwen Yuan, Guohui Jiang, Yuemei Xu, Jianfeng Ye, Lin Zhan, Wenhui Wang, Junfu
Published in
Experimental cell research
Capn4, a small regulatory subunit of the calpain proteolytic system, functions as a potential tumor promoter in several cancers. However, the biological functions and molecular mechanisms of Capn4 in gastric cancer (GC) remain poorly understood. In the current study, we found that upregulation of Capn4 was detected frequently in GC tissues, and was...
Xue, Xiaoxia Huang, Jin Yu, Kai Chen, Xinyue He, Yini Qi, Dianjun Wu, Ying
Published in
BMC Cancer
BackgroundAngiogenesis is important for the progression of gastric cancer (GC). Y-box binding protein 1 (YB-1) predicts advanced disease and indicates neovasculature formation in GC tissues, while the related mechanisms remain elusive. Exosomes mediate intercellular communications via transferring various molecules including proteins, lipids, mRNAs...
Yang, Yongqiang Ma, Yifu Xiang, Xiaoyong Xing, Pengfei Wu, Yongyou Zhang, Liyuan Tian, Ye
Published in
Radiation Oncology
BackgroundNearly 50% of new gastric cancer cases and gastric cancer-related deaths worldwide occur in China. No global consensus has been reached about the optimal management of locally advanced gastric cancer. Although the Guidelines for the Diagnosis and Treatment of Gastric Cancer from the National Health Commission of China, which has been upda...
Yao, Xingxing He, Zhanke Qin, Caolitao Deng, Xiangqian Bai, Lan Li, Guoxin Shi, Jiaolong
Published in
Cancer Cell International
BackgroundTumors display a high rate of glucose metabolism and the SLC2A (also known as GLUT) gene family may be central regulators of cellular glucose uptake. However, roles of SLC2A family in mechanism of metabolite communication with immunity in gastric cancer remains unknown.MethodsBioinformatics analysis and IHC staining were used to reveal th...
Sun, Yiting Li, Song Yu, Wenbin Zhao, Zeyi Gao, Jing Chen, Cheng Wei, Meng Liu, Teng Li, Lanbo Liu, Lian
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Published in
Cell Death & Disease
N6-methyladenosine (m6A) is the most common epigenetic RNA modification with essential roles in cancer progression. However, roles of m6A and its regulator METTL3 on non-coding RNA in gastric cancer are unknown. In this study, we found elevated levels of m6A and METTL3 in gastric cancer. Increased METTL3 expression indicated poor outcomes of patien...
