Vanhooren, Jolien; Van Camp, Laurens; Depreter, Barbara; de Jong, Martijn; Uyttebroeck, Anne; 58451; Van Damme, An; Dedeken, Laurence; Dresse, Marie-Francoise; ten Bosch, Jutte van der Werff; Hofmans, Mattias;
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Pediatric acute myeloid leukemia (pedAML) is a heterogeneous blood cancer that affects children. Although survival rates have significantly improved over the past few decades, 20-30% of children will succumb due to treatment-related toxicity or relapse. The molecular characterization of the leukemic stem cell, shown to be responsible for relapse, i...
Nollet, Lukas Campens, Laurence De Zaeytijd, Julie Leroy, Bart Hemelsoet, Dimitri Coucke, Paul J Vanakker, Olivier M
Published in
Journal of medical genetics
Biallelic pathogenic variants in the ATP-binding cassette subfamily C member 6 (ABCC6) gene cause pseudoxanthoma elasticum, a multisystemic ectopic calcification disorder, while heterozygous ABCC6 variants are associated with an increased risk of cardiovascular and cerebrovascular disease. As the prevalence of pathogenic ABCC6 variants in the gener...
Kleinberger, Irene Sanders, Ellen Staes, Katrien Van Troys, Marleen Hirano, Shinji Hochepied, Tino Lemeire, Kelly Martens, Liesbet Ampe, Christophe Van Roy, Frans
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Background Nonclustered mouse protocadherin genes (Pcdh) encode proteins with a typical single ectodomain and a cytoplasmic domain with conserved motifs completely different from those of classic cadherins. Alternative splice isoforms differ in the size of these cytoplasmic domains. In view of the compelling evidence for gene silencing of protocadh...
Xiang, Yanli Sapir, Thomas Rouillard, Pauline Ferrand, Marina Jiménez-Gómez, José M
Published in
BMC plant biology
Many biological processes follow circadian rhythmicity and are controlled by the circadian clock. Predictable environmental changes such as seasonal variation in photoperiod can modulate circadian rhythms, allowing organisms to adjust the timing of their biological processes to the time of the year. In some crops such as rice, barley or soybean, mu...
Lauffer, Peter; Boudin, Eveline; van der Kaay, Danielle CM; Koene, Saskia; van Haeringen, Arie; van Tellingen, Vera; Van Hul, Wim; Prickett, Timothy CR; Mortier, Geert; 151953; Espiner, Eric A;
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CONTEXT: Natriuretic peptide receptor-C (NPR-C, encoded by NPR3) belongs to a family of cell membrane-integral proteins implicated in various physiological processes, including longitudinal bone growth. NPR-C acts as a clearance receptor of natriuretic peptides, including C-type natriuretic peptide (CNP), that stimulate the cGMP-forming guanylyl cy...
Eitan, Chen; Siany, Aviad; Barkan, Elad; Olender, Tsviya; van Eijk, Kristel R; Moisse, Matthieu; Farhan, Sali MK; Danino, Yehuda M; Yanowski, Eran; Marmor-Kollet, Hagai;
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The noncoding genome is substantially larger than the protein-coding genome but has been largely unexplored by genetic association studies. Here, we performed region-based rare variant association analysis of >25,000 variants in untranslated regions of 6,139 amyotrophic lateral sclerosis (ALS) whole genomes and the whole genomes of 70,403 non-ALS c...
Schoofs, Kathleen Philippron, Annouck Avila Cobos, Francisco Koster, Jan Lefever, Steve Anckaert, Jasper De Looze, Danny Vandesompele, Jo Pattyn, Piet De Preter, Katleen
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Published in
Scientific data
In the past decades, the incidence of esophageal adenocarcinoma has increased dramatically in Western populations. Better understanding of disease etiology along with the identification of novel prognostic and predictive biomarkers are urgently needed to improve the dismal survival probabilities. Here, we performed comprehensive RNA (coding and non...
Rizzuti, Mafalda; Melzi, Valentina; Gagliardi, Delia; Resnati, Davide; Meneri, Megi; Dioni, Laura; Masrori, Pegah; Hersmus, Nicole; Poesen, Koen; 46862; Locatelli, Martina;
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Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disorder characterized by progressive degeneration of motor neurons (MNs). Most cases are sporadic, whereas 10% are familial. The pathological mechanisms underlying the disease are partially understood, but it is increasingly being recognized that alterations in RNA metabolism and dere...
Rajan-Babu, Indhu-Shree Phang, Gui-Ping Law, Hai-Yang Lee, Caroline G Chong, Samuel S
10.1016/j.jmoldx.2021.11.007 / JOURNAL OF MOLECULAR DIAGNOSTICS / 24 / 3 / 241-252
Comninos, AN Hansen, MS Courtney, A Choudhury, S Yang, L Mills, EG Phylactou, M Busbridge, M Khir, M Thaventhiran, T
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CONTEXT: Osteoporosis results from disturbances in bone formation and resorption. Recent non-human data suggests that the reproductive hormone, kisspeptin, directly stimulates osteoblast differentiation in vitro and thus could have clinical therapeutic potential. However, the effects of kisspeptin on human bone metabolism are currently unknown. OBJ...