Journal of Biomedical Science
Stem cell activity is subject to non-cell-autonomous regulation from the local microenvironment, or niche. In adaption to varying physiological conditions and the ever-changing external environment, the stem cell niche has evolved with multifunctionality that enables stem cells to detect these changes and to communicate with remote cells/tissues to...
Following improvement and integration of novel genome sequencing techniques, a new stage light has been shone upon circular RNAs (circRNA) in regard to their structure and functionality. In comparison to their linear counterparts, circRNA possess a multitude of remarkable functions such as microRNA (miRNA) sponging, RNA-binding protein (RBP) regula...
Learning & behavior
The sunk cost error is usually ascribed to the "ghost" of past investments, but the "promise-of-a-better-future" account is often difficult to dismiss. The search for the underpinning mechanism(s) is ongoing, but it should go hand-in-hand with a functional account.
The Canadian journal of nursing research = Revue canadienne de recherche en sciences infirmieres
The journal of spinal cord medicine
Context/Objective: To determine the relationship between the different functional aspects (as determined by the Spinal Cord Independence Measure) and quality of life (QOL) following a traumatic spinal cord injury (TSCI), considering clinical confounding factors.Design: Retrospective review of a prospective cohortSetting: A single Level-1 trauma cen...
BackgroundShotgun metagenomes are often assembled prior to annotation of genes which biases the functional capacity of a community towards its most abundant members. For an unbiased assessment of community function, short reads need to be mapped directly to a gene or protein database. The ability to detect genes in short read sequences is dependent...
The Journal of Headache and Pain
BackgroundMigraine is recognized as the second leading cause of disability globally. Lasmiditan is a novel, selective serotonin 5-HT1F receptor agonist developed for acute treatment of migraine. Here we analyzed effects of lasmiditan on migraine disability assessed with the Migraine Disability Assessment (MIDAS) scale for interim data from a long-t...
BMC Health Services Research
BackgroundReablement has potential for enhancing function and independence in people with dementia. In order to enhance the use of evidence-based reablement in this population, this study sought to understand the current practices and needs of the sector around these interventions.MethodsA purposive sample of 22 Australian aged and community-care p...
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed loops through backsplicing. Recent methodologies have enabled in-depth characterization of circRNAs for identification and potential functions. CircRNAs play important roles in various biological functions as microRNA sponges, transcriptional regulators and comb...
Biology & Philosophy
Jonathan Newman, Gary Varner, and Stefan Linquist’s Defending Biodiversity: Environmental Science and Ethics is a critical examination of a panoply of arguments for conserving biodiversity. Their discussion is extremely impressive though I think one can push back on some of their criticisms. In this essay, I consider their criticisms of the argumen...