Siddiqui, Shaziyaparveen K SahayaSheela, Vinodh J Kolluru, Srinivas Pandian, Ganesh N Santhoshkumar, Thankayyan R Dan, Vipin M Ramana, Chepuri V
Published in
Bioorganic & medicinal chemistry letters
In this manuscript we have documented the identification of a novel anticancer scaffold 3-(benzofuran-2-ylmethyl)-1H-indole. This scaffold has been designed by tweaking the known bisindolylmethane scaffold of natural products that display a wide range of biological activities. A series of 24 new conjugates have been synthesized and among them 5 der...
Gutiérrez de Souza, Cora Bersellini, Manuela Roelfes, Gerard
Published in
ChemCatChem
The supramolecular approach is among the most convenient methodologies for creating artificial metalloenzymes (ArMs). Usually this approach involves the binding of a transition metal ion complex to a biomolecular scaffold via its ligand, which also modulates the catalytic properties of the metal ion. Herein, we report ArMs based on the proteins Cgm...
Silva, Veronica D. da Silva, Rafaela R. Gonçalves Neto, João López-Corcuera, Beatriz Guimarães, Marilia Z. Noël, François Buarque, Camilla D.
Two series of new compounds containing 1,2,3-triazole moiety were designed as putative GlyT1 inhibitors aiming the discovery of new hits with activity in cognitive disorders. 1,4-Disubstituted α-hydroxy-1,2,3-triazoles were obtained as racemates in moderate to good yields by the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction (click ch...
Enjamuri, Nagasuresh Sarkar, Santu Reddy, Benjaram M Mondal, John
Published in
Chemical record (New York, N.Y.)
This review article encompasses the progress and conventional overview of current research activities of porous organic polymers (POPs), especially in catalysis, as they have garnered colossal interest in the scientific fraternity due to their intriguing characteristic features. Various synthetic strategies with possible modification of functionali...
Sarkar, Arijit Gómez-García, Carlos J Benmansour, Samia Nayek, Hari Pada
Published in
ChemPlusChem
A new multidentate ligand (H3 L) was synthesized by the condensation reaction of 4-tert-butyl-2,6-diformylphenol and 2-amino-4-nitrophenol. The reaction of the ligand with hydrated lanthanide nitrate produced two isostructural trinuclear coordination clusters: [DyLn3 L3 (DMF)3 (H2 O)2 ] ⋅ 3.8DMFLn=Dy (1) and Nd (2) (DMF=N, N-dimethylformamide). Sin...
Mai, Peter Coby, Lindsay Li, Shu-Ming
Published in
Applied Microbiology and Biotechnology
In nature, cyclic dipeptide prenyltransferases catalyze regioselective Friedel-Crafts alkylations of tryptophan-containing cyclic dipeptides. This enzyme class, belonging to the dimethylallyl tryptophan synthase superfamily, is known to be flexible toward aromatic prenyl acceptors, while mostly retaining its typical regioselectivity. Ardeemin fumiq...
Xu, Bo Wang, Bingyang Xun, Wen Qiu, Fayang G
Published in
Angewandte Chemie (International ed. in English)
A concise and highly stereoselective total synthesis of the Daphniphyllum alkaloids (-)-daphenylline has been accomplished. The synthesis was started from (S)-carvone and proceeded via a stereoselective Mg(ClO4 )2 -catalyzed intramolecular amide addition cyclization, an intramolecular Diels-Alder reaction to construct the ABCD tetracyclic core arch...
al-Kazaale, Nora; Tran, Phuong T; Haidari, Farhad; Solum, Eirik Johansson; Liekens, Sandra; 4782; Vervaeke, Peter; 63876; Sylte, Ingebrigt; Cheng, Jing-Jy; Vik, Anders; Hansen, Trond Vidar;
...
The endogenous steroid 2-methoxyestradiol (1) has attracted a great interest as a lead compound towards the development of new anti-cancer drugs. Herein, the synthesis, molecular modeling, anti-proliferative and anti-angiogenic effects of ten 2-ethyl and four 2-methoxy analogs of estradiol are reported. The ethyl group was introduced to the steroid...
Tian, Ke Zhu, Ting-Ting Lan, Ping Wu, Zheng-Chen Hu, Wei Xie, Fei-Fei Li, Lei
Published in
Chinese Journal of Polymer Science
Hyper-crosslinked polymers (HCPs) are promising materials for gas capture and storage because of their low cost and easy preparation. In this work, we report the massive preparation of coumarone-indene resin-based hyper-crosslinked polymers via one-step Friedel-Crafts alkylation. Low-cost coumarone-indene resin serves as the new building block and ...
Zhao, Hui Diao, Quanping Yu, Haifeng Li, Tiechun Liao, Peiqiu Hou, Dongyan
Published in
Chemical Research in Chinese Universities
A FeCl3·6H2O-catalyzed synthesis of β-ketothioesters from the hydrolysis reaction of chain α-oxoketene dithioacetals was carried out. Subsequently, we explored the FeCl3·6H2O-catalyzed Friedel-Crafts alkylation of the synthesized β-ketothioesters with alcohols in CH3CN at 25 °C, affording the desired α-alkylated β-ketothioesters in excellent yields...
