Tang, Yingyue Thiess, Lena Weiler, Sofia M E Tóth, Marcell Rose, Fabian Merker, Sabine Ruppert, Thomas Schirmacher, Peter Breuhahn, Kai
Published in
Cell communication and signaling : CCS
Cell–cell contact in epithelial cells is important for cell polarity, cellular compartmentalisation, as well as tissue architecture during development, homeostasis, and regeneration of adult tissues in metazoans. In this context, adherens junctions (AJs) mechanically sense cell contact information with direct impact on cytoskeletal remodelling, the...
Luo, Xiaofei Hang, Chengcheng Zhang, Ziming Le, Kaixing Ying, Yuhan Lv, Ying Yan, Lingling Huang, Yajie Ye, Lixia Xu, Xuefeng
...
Published in
Journal of the American Heart Association
Background Intrauterine growth restriction (IUGR) is closely related to systemic or pulmonary hypertension (PH) in adulthood. Aberrant crosstalk between pulmonary vascular endothelial cells (PVECs) and pulmonary arterial smooth muscle cells (PASMCs) that is mediated by exosomes plays an essential role in the progression of PH. FoxM1 (Forkhead box M...
Wang, Jing Dai, Wang Zhang, Ming
Published in
The International journal of neuroscience
Background: Neuroblastoma (NB) is a common malignancy occurring in infants and young children. Centrosome-associated protein E (CENPE) is a kinetochore-related motor protein highly expressed in NB, with the mechanism largely unknown. This study is committed to investigating the role and mechanism of CENPE in NB.Method: Short hairpin RNAs targeting ...
Detarya, Marutpong Thaenkaew, Salak Seubwai, Wunchana Indramanee, Somsiri Phoomak, Chatchai Saengboonmee, Charupong Wongkham, Sopit Wongkham, Chaisiri
Published in
Life sciences
Epidemiological studies indicate diabetes mellitus and hyperglycemia as risk factors of cancers including cholangiocarcinoma (CCA). How high glucose promotes cancer development and progression, however, is still unrevealed. In this study, insight into the molecular pathway of high glucose promoting progression of CCA cells was investigated. Human C...
Matsushita, Kohei Toyoda, Takeshi Yamada, Takanori Morikawa, Tomomi Ogawa, Kumiko
Published in
Journal of applied toxicology : JAT
Compensation is a physiological response that occurs during chemical exposure to maintain homeostasis. Because compensatory responses are not usually considered adverse effects, it is important to understand compensatory mechanisms for chemical risk assessment. Although the kidney is a major target organ for toxicity, there is controversy over whet...
Gu, Li Liu, Han-Min
Published in
World journal of pediatrics : WJP
Forkhead box M1 (FoxM1), a member of forkhead family, plays a key role in carcinogenesis, progression, invasion, metastasis and drug resistance. Based on the similarities between cancer and pulmonary arterial hypertension, studies on the roles and mechanisms of FoxM1 in pulmonary arterial hypertension have been increasing. This article aims to revi...
Wang, Wei Tan, Junyan
Published in
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Bromodomain and extra-terminal domain (BET) proteins are important epigenetic regulators that facilitate the transcription of genes in chromatin areas linked to acetylated histones. JQ1, a BET inhibitor (BETi), has anti-proliferative and apoptosis activity against many cancers including oral squamous cell carcinoma (OSCC). In this research, we inve...
Kongsema, Mesayamas Wongkhieo, Sudtirak Khongkow, Mattaka Lam, Eric W-F Boonnoy, Phansiri Vongsangnak, Wanwipa Wong-Ekkabut, Jirasak
Published in
Oncology reports
Breast cancer is the most common type of malignancies in women worldwide, and genotoxic chemotherapeutic drugs are effective by causing DNA damage in cancer cells. However, >90% of patients with metastatic cancer are resistant to chemotherapy. The Forkhead box M1 (FOXM1) transcription factor plays a pivotal role in the resistance of breast cancer c...
Tang, Cong Liu, Tianjie Wang, Ke Wang, Xinyang Xu, Shan He, Dalin Zeng, Jin
Published in
Oncology Reports
Hypoxia is a tumorigenesis-related microenvironment change which usually occurs in the earliest stage of prostate cancer (PCa) development. Accumulating evidence has demonstrated that hypoxia/hypoxia-inducing factor (HIF) is involved in the induction of epithelial-mesenchymal transition (EMT) and increased metastatic potential in PCa. However, the ...
Subramanian, Manickam Thotakura, Balaji Chandra Sekaran, Swathi Priyadarshini Jyothi, Ashok Kumar Sundaramurthi, Indumathi
Published in
Cells Tissues Organs
Background: Adult pancreatic beta cells, though quiescent, can proliferate in response to physiological need. This inherent character is used in exploring the possibilities of expanding the beta cell mass in the treatment of diabetes. Forkhead box M1 (FoxM1) transcription factor is an important regulator in the proliferation and survival of adult b...
