Acharya, Narayan Kandel, Ramji Roy, Priti Warriach, Irfan Singh, Kamaleshwar P
Published in
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
Kidney fibrosis is a commonly observed pathological condition during development of chronic kidney disease. Therapeutic options currently available are effective only in slowing the progression of kidney fibrosis and there is no cure for this disease. Aberrant expression and excessive accumulation of extracellular matrix (ECM) proteins in the perit...
Brown, Kenneth Tessema, Masresha McDonald, Christine Agbemafle, Isaac Woldeyohannes, Meseret Fereja, Mengistu Nane, Debritu Arnold, Charles Waka, Feyissa Tesfaye, Biniyam
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INTRODUCTION: The prevalence of neural tube defects (NTDs) is higher in Ethiopia than most other countries, and ~84% of Ethiopian women of reproductive age (WRA) have folate insufficiency, a major risk factor for NTDs. Salt fortification with folic acid is a potential strategy to improve womens folate status, but data are needed on the acceptabilit...
Metayer, Catherine Spector, Logan G Scheurer, Michael E Jeon, Soyoung Scott, Rodney J Takagi, Masatoshi Clavel, Jacqueline Manabe, Atsushi Ma, Xiaomei Hailu, Elleni M
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BackgroundPrenatal folate supplementation has been consistently associated with a reduced risk of childhood acute lymphoblastic leukemia (ALL). Previous germline genetic studies examining the one carbon (folate) metabolism pathway were limited in sample size, scope, and population diversity and led to inconclusive results.MethodsWe evaluated whethe...
Huang, Xiao Bao, Huihui Ding, Congcong Li, Junpei Cao, Tianyu Liu, Lishun Wei, Yaping Zhou, Ziyi Zhang, Nan Song, Yun
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BACKGROUND: While folic acid (FA) is widely used to treat elevated total homocysteine (tHcy), promoting vascular health by reducing vascular oxidative stress and modulating endothelial nitric oxide synthase, the optimal daily dose and individual variation by MTHFR C677T genotypes have not been well studied. Therefore, this study aimed to explore th...
Yu, Yizhou Chen, Civia Z Celardo, Ivana Tan, Bryan Wei Zhi Hurcomb, James D Leal, Nuno Santos Popovic, Rebeka Loh, Samantha HY Martins, L Miguel
Acknowledgements: The proteomics analysis was performed at the Cambridge Centre for Proteomics by R. Feret, M. Deery and Y. Umrania. We thank the Fly Facility, Department of Genetics, University of Cambridge, for maintaining the stocks and fly food; and M. Guerra Martin and N. Morone for assistance with the electron microscopy. This work was funded...
Abdi Aw-Nuur, Hana Abdullahi Diriye, Nasra Aasheim, Vigdis Engen, Tone Mehrara, Lydia Skirnisdottir Vik, Eline
Published in
Sexual & reproductive healthcare : official journal of the Swedish Association of Midwives
Health authorities in many countries recommend that women should take folic acid supplements before and during pregnancy to prevent having babies with neural tube defects. Somali immigrant women in Norway use less folic acid supplements than the recommended amount and subsequently, less than Norwegian-born women. To explore Somali immigrant women's...
Panoutsopoulos, Alexios Visina, Olesya Selhub, Jacob Borodinsky, Laura Knoepfler, Paul Balashova, Olga
Folate supplementation reduces the occurrence of neural tube defects (NTDs), birth defects consisting in the failure of the neural tube to form and close. The mechanisms underlying NTDs and their prevention by folate remain unclear. Here we show that folate receptor 1 (FOLR1) is necessary for the formation of neural tube-like structures in human-ce...
Rakoczy, Joanna Watson, Erica D
Maternal folate deficiency increases risk of congenital malformations, yet its effect on placenta development is unclear. Here, we investigated how folate-depleted culture medium affects the developmental potential of mouse trophoblast stem cells (TSCs). When cultured in stem cell conditions, TSC viability was unaffected by folate depletion, but ec...
Bouras, Emmanouil Kim, Andre Lin, Yi Morrison, John Du, Mengmeng Albanes, Demetrius Barry, Elizabeth Baurley, James Berndt, Sonja Bien, Stephanie
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BACKGROUND: Epidemiological and experimental evidence suggests that higher folate intake is associated with decreased colorectal cancer (CRC) risk; however, the mechanisms underlying this relationship are not fully understood. Genetic variation that may have a direct or indirect impact on folate metabolism can provide insights into folates role in ...
Feng, Ying Chang, Shannon K Portnoy, Daniel A
ImportanceFolic acid is an essential vitamin for bacteria, plants, and animals. The lack of folic acid leads to various consequences such as a shortage of amino acids and nucleotides that are fundamental building blocks for life. Though antifolate drugs are widely used for antimicrobial treatments, the underlying mechanism of bacterial folate defic...
