Yoosefee, Sadegh Amanat, Man Salehi, Mona Mousavi, Seyed Vahid Behzadmanesh, Jamshid Safary, Victoria Yoonesi, Ali Salehi, Bahman
Published in
BMC Psychiatry
BackgroundObsessive-compulsive disorder (OCD) is an anxiety disorder that causes impairment in daily activities. This study aimed to assess the safety and efficacy of transcranial direct current stimulation (tDCS) as adjunctive therapy with fluoxetine in individuals diagnosed with moderate to severe OCD.MethodsThis is a randomized, double-blind sha...
Rasti, Aryana R. Coombe, Victoria E. Muzik, Jerica R. Kliethermes, Christopher L.
Published in
Invertebrate Neuroscience
The forced swim test is commonly used as a preclinical screen of antidepressant medication efficacy in rats and mice. Neckameyer and Nieto-Romero (Stress 18:254–66, 2015) adopted the forced swim test for use with the fruit fly Drosophila melanogaster and showed that behavior in this test is sensitive to several physiologically relevant stressors. H...
Borsoi, Milene Nunes, Luis Eduardo D Barbosa, Amanda R Lima, Mariana S Medeiros, Isabelle Pranke, Mariana A Antonio, Camila B Rates, Stela M K Neves, Gilda A
Published in
Neuroscience letters
Discovery of the rapid antidepressant effect of ketamine has been considered one of the most important advances in major depressive disorder treatment. Several studies report a significant benefit to patients that lasts up to 19 days after treatment. However, concerns arise from the long-term use of ketamine, thus a safe and effective strategy for ...
Xie, Bin Hao, Changchun Sun, Runguang
Published in
Biochimica et biophysica acta. Biomembranes
Fluoxetine (FLX), approved for the treatment of depression and anxiety by the FDA in 2002, is an amphiphilic antidepressant. In general, amphiphilic drugs have high membrane permeability. Therefore, the interactions between these drugs and monolayers have been widely concerned. In this study, the adsorption of FLX on dipalmitoylphosphatidylcholine ...
Bteich, Michel Poulin, Patrick Piette, Sarah Haddad, Sami
Published in
Journal of pharmaceutical sciences
The main objective was to investigate the effect of albumin (ALB) and/or alpha-1-acid glycoprotein (AGP) on the hepatic clearance (CLh) of the drugs that bind, extensively, to both proteins. Isolated perfused livers from male Sprague Dawley rats (IPRL) were performed for perampanel (PER) and fluoxetine (FLU), using physiological solutions in four s...
Hegstad, Jan Huijgens, Patty T Houwing, Danielle J Olivier, Jocelien D A Heijkoop, Roy Snoeren, Eelke M S
Published in
Psychoneuroendocrinology
Serotonin plays an important role in adult female sexual behavior, however little is known about the influence of serotonin during early development on sexual functioning in adulthood. During early development, serotonin acts as neurotrophic factor, while it functions as a modulatory neurotransmitter in adulthood. The occurrence of serotonin releas...
Villani, Claudia Sacchetti, Giuseppina Carli, Mirjana Invernizzi, Roberto W
Published in
Neuropharmacology
Motor skill is a specific area of disability of Rett syndrome (RTT), a rare disorder occurring almost exclusively in girls, caused by loss-of-function mutations of the X-linked methyl-CpG-binding protein2 (MECP2) gene, encoding the MECP2 protein, a member of the methyl-CpG-binding domain nuclear proteins family. Brain 5-HT, which is defective in RT...
Li, Ru Qu, Jingsi Wu, Cairu Fang, Zeman Hong, Xiaohong Xu, Haiyun
Published in
European journal of pharmacology
Fluoxetine is one of SSRIs commonly used as first-line antidepressants. It also induces adverse effects, including bleeding events. This study clarified the bleeding effect of fluoxetine and explored the action cascade of this drug leading to a longer bleeding time. A total of 48 male adult mice were evenly distributed into four groups and given fl...
Zavvari, Fahime Nahavandi, Arezo
Published in
Physiology & behavior
Axonal transport deficit is a key mechanism involved in neurodegenerative conditions. Fluoxetine, a commonly used antidepressant for treatment of depression, is known to regulate several important structural and neurochemical aspects of hippocampal functions. However, the mechanisms underlying these effects are still poorly understood. This study a...
de la Peña, Francisco Rafael Cruz-Fuentes, Carlos Palacios, Lino Girón-Pérez, Manuel Iván Medina-Rivero, Emilio Ponce-Regalado, Maria Dolores Alvarez-Herrera, Samantha Pérez-Sánchez, Gilberto Becerril-Villanueva, Enrique Maldonado-García, José Luis
...
Published in
World Journal of Psychiatry
BACKGROUND Major depressive disorder (MDD) is a global health issue that affects 350 million people of all ages. Although between 2% and 5.6% of affected individuals are adolescents, research on young patients is limited. The inflammatory response contributes to the onset of depression, and in adult MDD patients, symptom severity has been linked to...
