Hertegård, Stellan Nagubothu, Srinivasa Rau Malmström, Emma LeBlanc, Katarina
Published in
Stem Cell Research & Therapy
BackgroundVocal fold (VF) scarring, caused by surgery or inflammation, often results in severe voice problems or aphonia. Effective lasting treatment is lacking. Previous in vitro and in vivo animal studies reported positive effects on VF scar resolution with mesenchymal stromal cell (MSC) implantation. The principal aim of this study was to examin...
Todd, Jamie L. Vinisko, Richard Liu, Yi Neely, Megan L. Overton, Robert Flaherty, Kevin R. Noth, Imre Newby, L. Kristin Lasky, Joseph A. Olman, Mitchell A.
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Published in
BMC Pulmonary Medicine
BackgroundMatrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMPs) play important roles in the turnover of extracellular matrix and in the pathogenesis of idiopathic pulmonary fibrosis (IPF). This study aimed to determine the utility of circulating MMPs and TIMPs in distinguishing patients with IPF from controls and to explore associa...
Kolentinis, Michalis Maestrini, Viviana Vidalakis, Eleftherios Cimino, Sara Arcari, Luca
Published in
Current Cardiovascular Imaging Reports
Purpose of ReviewMyocardial left ventricular (LV) hypertrophy (LVH) is a common phenotype associated to increased morbidity and mortality. Beyond an accurate LV mass quantification, cardiovascular magnetic resonance (CMR) can also provide tissue characterization, perfusion, and deformation assessments. Aim of the present review is to discuss recent...
Patel, Preya Janubhai Cheng, Johnson Chieh-Yu Banh, Xuan Gracen, Lucy Radford-Smith, Daniel Hossain, Fabrina Horsfall, Leigh Ula Hayward, Kelly Lee Williams, Suzanne Johnson, Tracey
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Published in
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
There is limited knowledge regarding the longitudinal utility of biomarkers of fibrosis, such as the nonalcoholic fatty liver disease (NAFLD) fibrosis score (NFS) or the fibrosis-4 score (FIB-4) score. We examined longitudinal changes in the NFS and the FIB-4 score in patients with NAFLD, with and without clinically significant fibrosis (CSF). We p...
Sato, Shin Norikura, Toshio Mukai, Yuuka Yamaoka, Shin Mikame, Keigo
Published in
Chemico-biological interactions
Excess weight and obesity increase the risk of developing major risk factors for chronic kidney disease. Lignin comprises 20%-30% of the global plant biomass; however, it is not well utilized because of its resistance to chemical and biological degradation. We investigated whether low-molecular-weight oxidized lignophenol (LOLP), a lignin derivativ...
Gharaviri, Ali Bidar, Elham Potse, Mark Zeemering, Stef Verheule, Sander Pezzuto, Simone Krause, Rolf Maessen, Jos Auricchio, Angelo Schotten, Ulrich
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Background: Atrial fibrillation (AF) is accompanied by progressive epicardial fibrosis, dissociation of electrical activity between the epicardial layer and the endocardial bundle network, and transmural conduction (breakthroughs). However, causal relationships between these phenomena have not been demonstrated yet. Our goal was to test the hypothe...
Aimo, Alberto Cerbai, Elisabetta Bartolucci, Gianluca Adamo, Luigi Barison, Andrea Lo Surdo, Giuseppa Biagini, Stefania Passino, Claudio Emdin, Michele
Published in
Pharmacological research
Myocardial fibrosis is an endogenous response to different cardiac insults that may become maladaptive over time and contribute to the onset and progression of heart failure (HF). Fibrosis is a direct and indirect target of established HF therapies, namely inhibitors of the renin-angiotensin-aldosterone system, but its resilience to therapy warrant...
Epstein Shochet, Gali Brook, Elizabetha Bardenstein-Wald, Becky Shitrit, David
Published in
Respiratory Research
BackgroundIdiopathic pulmonary fibrosis (IPF) is a chronic and ultimately fatal disease characterized by a progressive decline in lung function. Fibrotic diseases, such as IPF, are characterized by uncontrolled activation of fibroblasts. Since the microenvironment is known to affect cell behavior, activated fibroblasts can in turn activate healthy ...
Mathai, Clinton Jourd'heuil, Frances L Lopez-Soler, Reynold I Jourd'heuil, David
Published in
Redox biology
Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather than constrained to penta coordination, cytoglobin's heme iron may exist either as a penta or hexacoordinated arrangement when exposed to different intracellular environments. Two cysteine residues at the surface of the protein form an intramolecular disulfide ...
Yoo, Myung Hi Kim, Hye Jeong Choi, In Ho Park, Suyeon Kim, Sang Jin Park, Hyeong Kyu Byun, Dong Won Suh, Kyoil
Published in
BMC Cancer
BackgroundAlthough shear wave elastography (SWE) is reported to be useful in detecting malignant thyroid nodules, it shows a wide range of cut-off values of elasticity index (EI) in detecting malignant nodules. The cause of discrepancy remains unclear. Fibrosis of the tumors is known to increase the EI in SWE, and matching of SWE and surgical histo...
