Xu, Chengcheng Bao, Meng Fan, Xiaorong Huang, Jin Zhu, Changhong Xia, Wei
Published in
Reproductive Biology and Endocrinology
BackgroundIntrauterine adhesion (IUA) is one of the leading causes of infertility and the main clinical challenge is the high recurrence rate. The key to solving this dilemma lies in elucidating the mechanisms of endometrial fibrosis. The aim of our team is to study the mechanism underlying intrauterine adhesion fibrosis and the origin of fibroblas...
Dehghani, Tima Thai, Phung N Sodhi, Harkanwalpreet Ren, Lu Sirish, Padmini Nader, Carol E Timofeyev, Valeriy Overton, James L Li, Xiaocen Lam, Kit S
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Published in
Cardiovascular research
One of the hallmarks of myocardial infarction (MI) is excessive inflammation. During an inflammatory insult, damaged endothelial cells shed their glycocalyx, a carbohydrate-rich layer on the cell surface which provides a regulatory interface to immune cell adhesion. Selectin-mediated neutrophilia occurs as a result of endothelial injury and inflamm...
Lee, Hae Lim Lee, Jungmin Cha, Jung Hoon Cho, Sungwoo Sung, Pil Soo Hur, Wonhee Yoon, Seung Kew Bae, Si Hyun
Published in
The Korean journal of internal medicine
Patients with liver cirrhosis (LC) have low levels of branched-chain amino acids (BCAAs). There is accumulating evidence that BCAAs have anti- fibrotic effects in cirrhosis. This study is aimed to evaluate the effect of BCAAs on the function and phenotype of activated hepatic stellate cells (HSCs). LX-2, an immortalized human stellate cell line, wa...
Mazza, Stefano Conforti, Francesco Simone Forzenigo, Laura Virginia Piazza, Nicole Bertè, Roberto Costantino, Andrea Fraquelli, Mirella Coletta, Marina Rimola, Jordi Vecchi, Maurizio
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Published in
Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
the assessment of fibrosis in Crohn's disease (CD) bowel lesions helps to guide therapeutic decisions. Real-time elastography (RTE) and delayed-enhancement magnetic resonance enterography (DE-MRE) have demonstrated good accuracy in quantifying CD-related ileal fibrosis as compared with histological examination. To date no study has compared DE-MRE ...
Pozder geb. Gehlken, Carolin Rogier van der Velde, A. Meijers, Wouter C. Silljé, Herman H.W. Muntendam, Pieter Dokter, Martin M. Schols, Henk A.
Purpose of the study: A major challenge in cardiology remains in finding a therapy for cardiac fibrosis. Inhibition of galectin-3 with pectins attenuates fibrosis in animal models of heart failure. The purpose of this study is to identify pectins with the strongest galectin-3 inhibitory capacity. We evaluated the in vitro inhibitory capacity, ident...
Arroyo, Noelia Villamayor, Laura Díaz, Irene Carmona, Rita Ramos-Rodríguez, Mireia Muñoz-Chápuli, Ramón Pasquali, Lorenzo Toscano, Miguel G Martín, Franz Cano, David A
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Published in
JCI insight
In response to liver injury, hepatic stellate cells activate and acquire proliferative and contractile features. The regression of liver fibrosis appears to involve the clearance of activated hepatic stellate cells, either by apoptosis or by reversion toward a quiescent-like state, a process called deactivation. Thus, deactivation of active hepatic...
Varghese, Jijo K V, Anoop Devadas, Krishnadas Tom, Tharun
Published in
The Egyptian Journal of Internal Medicine
BackgroundThe aim of this study was to propose a simple predictive score to differentiate NASH from simple steatosis.ResultsThis study included 64 patients who had biopsy-proven NAFLD, of which 34 patients had steatohepatitis and 30 had simple steatosis. Clinical, anthropometric, and biochemical variables of the study population were analyzed. Univ...
Amernia, Behnaz Moosavy, Seyed Hamid Banookh, Fatemeh Zoghi, Ghazal
Published in
BMC Gastroenterology
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease worldwide. Researchers have tried to develop indices to assess liver fibrosis in NAFLD patients to avoid liver biopsy. In this study we aimed to compare fibrosis-4 (FIB-4), aspartate aminotransferase (AST) to platelet ratio index (APRI), and aspartate amino...
O'Reilly, Steven
Published in
Cellular and molecular life sciences : CMLS
Gremlin-1 is part of the TGF-β superfamily and is a BMP antagonist that blocks BMP signalling to precisely control BMP gradients. Gremlin-1 is primarily involved in organogenesis and limb patterning however, has recently been described as being involved in fibrotic diseases. Initially described as a key factor involved in diabetic kidney fibrosis d...
Marcelin, Geneviève Clément, Karine
Published in
Reviews in endocrine & metabolic disorders
While obesity is defined as an excessive fat accumulation conferring a risk to metabolic health, increased adipose mass by itself does not fully explain obesity's propensity to promote metabolic alterations. Adipose tissue regulates multiple processes critical for energy homeostasis and its dysfunction favors the development and perpetuation of met...
