Wang, Tiancheng Zhou, Zhenwei Luo, Enjing Zhong, Jinghong Zhao, Daqing Dong, Haisi Yao, Baojin
Published in
Cellular & Molecular Biology Letters
Background Keratinocytes and fibroblasts represent the major cell types in the epidermis and dermis of the skin and play a significant role in maintenance of skin homeostasis. However, the biological characteristics of keratinocytes and fibroblasts remain to be elucidated. The purpose of this study was to compare the gene expression pattern between...
Ibrahim, Ayman M. Bilsland, Alan Rickelt, Steffen Morris, Joanna S. Stein, Torsten
Published in
Breast Cancer Research : BCR
Background During pregnancy, the mouse mammary ductal epithelium branches and grows into the surrounding stroma, requiring extensive extracellular matrix (ECM) and tissue remodelling. It therefore shows parallels to cancer invasion. We hypothesised that similar molecular mechanisms may be utilised in both processes, and that assessment of the strom...
Bourne, Debra A James, Isaac Wang, Sheri Bliley, Jacqueline Grahovac, Tara Mitchell, Ryan Tm Brown, Spencer A Ambrosio, Fabrisia Ho, Jonhan Lannau, Bernd
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Published in
Journal of plastic, reconstructive & aesthetic surgery : JPRAS
Yang, Jinxiu Li, Shiyi He, Leren Chen, Minliang
Published in
Burns & Trauma
Background The clinical features of keloids consist of aberrant proliferation, secretion, differentiation and apoptosis of keloid dermis-derived fibroblasts (KFBs). Notably, the apoptosis rate of KFBs is lower than the proliferation rate. Though the anti-fibrotic effect of adipose-derived stem cells (ADSCs) on keloids has become a hot topic of rese...
Wei, Wei Gaffney, Daniel J Chinnery, Patrick F
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and fibroblast lines from 151 donors, we show that most age-related fibroblast mtDNA mutations are lost during reprogramming. However,...
Jabłońska-Trypuć, Agata Wydro, Urszula Wołejko, Elżbieta Pietryczuk, Anna Cudowski, Adam Leszczyński, Jacek Rodziewicz, Joanna Janczukowicz, Wojciech Butarewicz, Andrzej
Published in
Environmental geochemistry and health
Leachate from landfills is a product of complex biological and physicochemical processes occurring during waste storage. In the present study, the toxicity of landfill leachate (LL) to human and bacterial cells was investigated for better understanding of LL environmental toxicity. Studies regarding LL physicochemical properties and cytotoxicity an...
Napoli, Eleonora Flores, Amanda Mansuri, Yasmeen Hagerman, Randi J Giulivi, Cecilia
CGG expansions between 55 and 200 in the 5'-untranslated region of the fragile-X mental retardation gene (FMR1) increase the risk of developing the late-onset debilitating neuromuscular disease Fragile X-Associated Tremor/Ataxia Syndrome (FXTAS). While the science behind this mutation, as a paradigm for RNA-mediated nucleotide triplet repeat expans...
Del Rey, Manuel J. Meroño, Carolina Municio, Cristina Usategui, Alicia Mittelbrunn, María García-Consuegra, Inés Criado, Gabriel Pablos, José L.
Published in
Disease Models & Mechanisms
Summary: TFAM depletion in skin fibroblasts ex vivo results in a senescent and inflammatory phenotype, providing a valuable model to investigate the role of mitochondrial dysfunction in ageing and inflammatory pathologies.
Kaneshita, Shunya Kida, Takashi Yoshioka, Makoto Nishioka, Keisuke Raje, Mithun Sakashita, Aki Hirano, Aiko Sagawa, Tomoya Kasahara, Akiko Inoue, Takuya
...
Published in
Pulmonary pharmacology & therapeutics
Pulmonary fibrosis is a progressive disease with poor prognosis and limited therapeutic options. In this study, we evaluated the potential therapeutic effects of CG223, a novel inhibitor of bromodomain and extra-terminal motif (BET) proteins, on pulmonary fibrosis by focusing on the transforming growth factor-β1 (TGF-β1) pathway. In a murine model ...
Wei, Wei Gaffney, Daniel J Chinnery, Patrick
Individual induced pluripotent stem cells (iPSCs) show considerable phenotypic heterogeneity, but the reasons for this are not fully understood. Comprehensively analysing the mitochondrial genome (mtDNA) in 146 iPSC and fibroblast lines from 151 donors, we show that most age-related fibroblast mtDNA mutations are lost during reprogramming. However,...
