Fernández, Marbely C Kopton, Ramona A Simon-Chica, Ana Madl, Josef Hilgendorf, Ingo Zgierski-Johnston, Callum M Schneider-Warme, Franziska
Published in
Methods in molecular biology (Clifton, N.J.)
Optogenetic approaches have evolved as potent means to investigate cardiac electrophysiology, with research ranging from the study of arrhythmia mechanisms to effects of cardiac innervation and heterocellular structural and functional interactions, both in healthy and diseased myocardium. Most commonly, these studies use channelrhodopsin-2 (ChR2)-e...
Feng, Huan Huang, Xiaobing Fu, Weihua Dong, Xingyou Yang, Fengxia Li, Longkun Chu, Lingling
Published in
Life sciences
Transforming growth factor-β (TGF-β) mediated super-activation of urethra fibroblasts contributes to the progression of traumatic urethral stricture (TUS), and the Rho-associated kinase inhibitors, Fasudil, might be a novel therapeutic agent for TUS, but the underlying mechanisms had not been studied. The primary urethral fibroblasts (PUFs) were is...
Yang, Chao Liu, Wei Zhang, Xianlong Zeng, Bingfang Qian, Yebin
Published in
Journal of Orthopaedic Surgery and Research
BackgroundThe osteoclast bone resorption is critical in aseptic loosening after joint replacement. The balance between activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) is considered to play a central role in osteoclast maturation. Fibroblasts from the periprosthetic membrane express RANKL and promote osteoclast formation...
Nishida, Yasunori Nagatsuma, Akiko Kawano Kojima, Motohiro Gotohda, Naoto Ochiai, Atsushi
Published in
BMC Gastroenterology
BackgroundStromal fibroblasts associated with pancreatic ductal adenocarcinoma (PDAC) play an important role in tumor progression through interactions with cancer cells. Our proposed combination strategies of in vitro and in silico biomarker screening through a cancer-stromal interaction model were previously identified several actin-binding protei...
Tsuka, Yuji Kunimatsu, Ryo Gunji, Hidemi Abe, Takaharu Medina, Cynthia Concepción Hiraki, Tomoka Nakatani, Ayaka Sakata, Shuzo Rikitake, Kodai Aisyah, Purtranti Nurul
...
Published in
Lasers in medical science
Prolonged treatment and painful tooth movement are major problems for patients undergoing orthodontic treatment. Accelerating the movement of teeth leads to shortening of the treatment period, so various studies on the movement of teeth have been conducted in the field of orthodontics. In previous studies, we performed a fiber incision-like fiberot...
Fujioka-Kobayashi, Masako Katagiri, Hiroki Kono, Michihide Schaller, Benoit Zhang, Yufeng Sculean, Anton Miron, Richard J
Published in
Clinical oral investigations
Several studies have recently demonstrated that only marginal improvements in platelet and leukocyte concentrations are achieved following standard injectable platelet-rich fibrin (i-PRF) protocols. Due to these previous findings, a novel harvesting technique was recently developed to collect higher concentrations of platelets/leukocytes specifical...
Pansani, Taisa Nogueira Basso, Fernanda Gonçalves de Souza Costa, Carlos Alberto
Published in
Lasers in medical science
Photobiomodulation (PBM) therapy is used to stimulate cell proliferation and metabolism, as well as reduce inflammatory cytokine synthesis, which plays a main role in the long-term stability of implants. This study assessed the response of gingival fibroblasts cultured on titanium (Ti) and zirconia (ZrO2), submitted to PBM and exposed to lipopolysa...
Cogswell, Devon Sun, Mei Greenberg, Erin Margo, Curtis E Espana, Edgar M
Published in
The ocular surface
To develop a stromal wound healing model and a reliable scar classification score system that correlates photographic evaluation with changes in the structure and organization of the extracellular matrix. We tested three stromal injury techniques in adult C57BL/6 mice. Technique 1, a lineal partial thickness keratotomy in the horizontal axis. Techn...
Mazlan, Muhammad Alif Isa, Muhammad Lokman Md. Ibrahim, Moustafa
Published in
Egyptian Journal of Medical Human Genetics
BackgroundThe primary cause of cancer is gene mutation which allows the growth of abnormal and damaged cells. Nutrition is one of the key factors that either increases or decreases the risk of cancer. Mannose has been found in many fruits such as oranges, apples and berries. Mannose has been linked to increase the risk factors or potential therapeu...
Showalter, Kimberly Gordon, Jessica K.
Published in
Current Rheumatology Reports
Purpose of ReviewSystemic sclerosis (SSc) is a life-threatening autoimmune disease that causes debilitating skin fibrosis. The skin in SSc is easily accessible, and skin biopsies may provide rich biological data regarding underlying disease pathophysiology. Here, we review literature relevant to the potential for skin histology to serve as a diagno...