Damhuis, Stefanie E. Ganzevoort, Wessel Duijnhoven, Ruben G. Groen, Henk Kumar, Sailesh Heazell, Alexander E. P. Khalil, Asma Gordijn, Sanne J.
Published in
BMC Pregnancy and Childbirth
BackgroundRoutine assessment in (near) term pregnancy is often inaccurate for the identification of fetuses who are mild to moderately compromised due to placental insufficiency and are at risk of adverse outcomes, especially when fetal size is seemingly within normal range for gestational age. Although biometric measurements and cardiotocography a...
Hannan, Natalie J. Stock, Owen Spencer, Rebecca Whitehead, Clare David, Anna L. Groom, Katie Petersen, Scott Henry, Amanda Said, Joanne M. Seeho, Sean
...
Published in
BMC Medicine
BackgroundFetuses affected by placental insufficiency do not receive adequate nutrients and oxygenation, become growth restricted and acidemic, and can demise. Preterm fetal growth restriction is a severe form of placental insufficiency with a high risk of stillbirth. We set out to identify maternal circulating mRNA transcripts that are differentia...
Maki, Yohei Nygard, Karen Hammond, Robert R. Regnault, Timothy R.H. Richardson, Bryan S.
Published in
Developmental Neuroscience
Background: We determined whether maternal nutrient restriction (MNR) in guinea pigs leading to fetal growth restriction (FGR) impacts markers for brain hypoxia and oxidative stress. Methods: Guinea pigs were fed ad libitum (control) or 70% of the control diet before pregnancy, switching to 90% at mid-pregnancy (MNR). Near term, hypoxyprobe-1 (HP-1...
Raghuraman, Nandini
Published in
Seminars in perinatology
Electronic fetal monitoring (EFM) is the most commonly used tool to screen for intrapartum fetal hypoxia. Category II EFM is present in over 80% of laboring patients and poses a unique challenge to management given the breadth of EFM features that fall within this category. Certain Category II patterns, such as recurrent late or recurrent variable ...
Tarvonen, Mikko Sainio, Susanna Hämäläinen, Esa Hiilesmaa, Vilho Andersson, Sture Teramo, Kari
Published in
Neonatology
Background: While late decelerations and major bradycardia episodes in intrapartum cardiotocography (CTG) recordings are known to correlate with fetal distress,little is known of the importance of the saltatory pattern. Objective: The aim of the study was to examine whether the fetal heart rate (FHR) saltatory pattern in intrapartum CTG registratio...
Houzé de l'Aulnoit, A Génin, M Boudet, S Demailly, R Ternynck, C Babykina, G Houzé de l'Aulnoit, D Beuscart, R
Published in
Computers in biology and medicine
To identify clinical parameters and intrapartum fetal heart rate parameters associated with a risk of umbilical cord acidosis at birth, using an automated analysis method based on empirical mode decomposition. Our single-center study included 381 cases (arterial cord blood pH at birth pHa ≤7.15) and 1860 controls (pHa ≥7.25) extracted from a databa...
Houzé de l'Aulnoit, Agathe
L’analyse visuelle du rythme cardiaque fœtal (RCF) est une excellente méthode de dépistage de l’hypoxie fœtale. Cette analyse visuelle est d’autre part sujette à une variabilité inter- et intra-individuelle importante. L’hypoxie fœtale au cours du travail s’exprime par des anomalies du RCF. La sous-évaluation de la gravité d’un RCF entraine une pri...
Rossidis, Avery C. Baumgarten, Heron D. Lawrence, Kendall M. McGovern, Patrick E. Mejaddam, Ali Y. Li, Haiying Hwang, Grace Young, Kathleen Peranteau, William H. Davey, Marcus G.
...
Published in
Fetal Diagnosis and Therapy
Introduction: We have recently developed an extra-uterine environment for neonatal development (EXTEND) capable of supporting premature fetal lambs and have been able to replicate hypoxic in utero conditions by controlling fetal oxygen delivery. In this study, we investigated the fetal mitochondrial response to hypoxia. Methods: Eight premature fet...
Ludwig, Hans
Published in
Der Gynäkologe
Paul Zweifel (1848-1927) und Fred Kubli (1930-1987) waren beide Forscher, die sich mit der Physiologie des ungeborenen Kindes befasst haben, im Abstand von nahezu hundert Jahren. Zweifel beschrieb das Vorhandensein fetaler Atmung auf dem Boden tierexperimenteller Beobachtungen, Kubli beschäftigte die intrauterine Asphyxie, wobei er sich auf CTG(Kar...
Dunn, Liam Greer, Ristan Flenady, Vicki Kumar, Sailesh
Published in
Fetal Diagnosis and Therapy
Introduction: This systematic review evaluates maternal tolerance and obstetric and perinatal outcomes following sildenafil citrate (SC) use in human pregnancy. Data Sources: Scopus, PubMed, Cochrane Library, Web of Science, Embase, and Google Scholar were searched. Relevant full-text studies including case series and reports in English were includ...
