Jiang, Feng Li, Xinxin Xie, Zhiyang Liu, Lei Wu, Xiaotao Wang, Yuntao
Published in
Biochemical genetics
Approximately 80% of individuals encounter lower back pain (LBP), a prevalent clinical issue largely attributed to intervertebral disc degeneration (IDD). Ferroptosis is an iron-dependent lipid peroxidation-driven cell death, and there is growing evidence that ferroptosis plays an important role in various human diseases. However, the underlying me...
Lai, Guorong Shen, Jie Hu, Yanhui Yang, Fan Zhang, Chao Le, Dongsheng Liu, Qin Liang, Yingping
Published in
Biochemical genetics
Ferroptosis is a new way of cell death which is reported to participate in the pathology of myocardial ischemia-reperfusion (MI/R) injury, but it's mechanism remains unclear. The present investigation is to study the emerging role of long non-coding RNA (lncRNA) regulator of reprogramming (ROR) in cardiomyocyte ferroptosis after hypoxia/reoxygenati...
Yuan, Lin Zhou, Di Li, Weiwen Guan, Jianhua Li, Junda Xu, Bo
Published in
Biochemical genetics
Cystatin SN (CST1) appears to have pro-tumor effects in breast cancer (BC) and is involved in ferroptosis; however, there is no report on the regulation of ferroptosis by CST1 for BC development. The purpose of this study is to investigate the functions and mechanisms operated by CST1 in BC development and ferroptosis. Transcription Factor Activato...
Roh, Jong-Lyel
Published in
Critical reviews in oncology/hematology
The diverse functions of ferroptosis suppressor protein 1 (FSP1/AIFM2) in cancer have positioned it as a promising therapeutic target across various malignancies, including head and neck cancer (HNC). Initially characterized as a potential tumor suppressor due to its involvement in apoptosis and ferroptosis, recent studies have revealed its complex...
Han, Songtao Wang, Senyu Li, Yuxia He, YuJiao Ma, Jing Feng, Yangchun
Published in
Discover oncology
Ferroptosis can be used as a powerful predictor of cancer prognosis. HPV persistent infection is the main cause of cervical cancer, so it is very important to improve the prognosis of patients. Therefore, it is necessary to explore the value of HPV-ferroptosis related genes as prognostic biomarkers of cervical cancer patients. In this study, differ...
Yang, Dong Zhang, Tiling Qu, Hai Li, Shaolong Lu, Jing Cao, Wanyan Chen, Zhipeng Zhang, Han Yang, Jing Wang, Jin
...
Published in
Cellular signalling
Our prior research determined that USP7 exacerbates myocardial injury. Additionally, existing studies indicate a strong connection between USP7 and ferroptosis. However, the influence of USP7 on ferroptosis-mediated myocardial infarction (MI) remains unclear. Given these findings, we are particularly interested in USP7's regulatory role in ferropto...
Zhou, Rui Wei, Kexin Li, Xinyu Yan, Beibei Li, Lin
Published in
Frontiers in Microbiology
Ferroptosis is a novel form of programmed cell death, which is different from apoptosis, pyroptosis and autophagy in morphology and biochemistry. Ferroptosis is characterized by condensed mitochondrial membrane densities, vanished of mitochondria crista and outer membrane rupture in morphology, and the accumulation of intracellular iron, lipid pero...
Sanz-Alcázar, Arabela Portillo-Carrasquer, Marta Delaspre, Fabien Pazos-Gil, Maria Tamarit, Jordi Ros, Joaquim Cabiscol, Elisa
Published in
Redox biology
Friedreich ataxia (FA) is a rare neurodegenerative disease caused by decreased levels of the mitochondrial protein frataxin. Frataxin has been related in iron homeostasis, energy metabolism, and oxidative stress. Ferroptosis has recently been shown to be involved in FA cellular degeneration; however, its role in dorsal root ganglion (DRG) sensory n...
Zhang, Yang Zha, Tianming Song, Guoxin Abudurousuli, Gulibositan Che, Jinxin Zhao, Fei Zhang, Lin Zhang, Xing Gui, Bo Zhu, Linjia
...
Published in
Pulmonary pharmacology & therapeutics
Acute lung injury (ALI) frequently occurs after video-assisted thoracoscopic surgery (VATS). Ferroptosis is implicated in several lung diseases. Therefore, the disparate effects and underlying mechanisms of the two commonly used anesthetics (sevoflurane (Sev) and propofol) on VATS-induced ALI need to be clarified. In the present study, enrolled pat...
Zhu, Yang Ding, Chengyu Fang, Wenhua Li, Tuanwei Yan, Lingjun Tian, Yu Huang, Wei Wei, Penghui Ma, Jing Lin, Xin
...
Published in
Acta biomaterialia
The effectiveness of tumor treatment using reactive oxygen species as the primary therapeutic medium is hindered by limitations of tumor microenvironment (TME), such as intrinsic hypoxia in photodynamic therapy (PDT) and overproduction of reducing glutathione (GSH) in chemodynamic therapy (CDT). Herein, we fabricate metal-polyphenol self-assembled ...
