Proud, Pamela C. Tsitoura, Daphne Watson, Robert J. Chua, Brendon Y. Aram, Marilyn J. Bewley, Kevin R. Cavell, Breeze E. Cobb, Rebecca Dowall, Stuart Fotheringham, Susan A.
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Published in
EBioMedicine
Background The novel human coronavirus SARS-CoV-2 is a major ongoing global threat with huge economic burden. Like all respiratory viruses, SARS-CoV-2 initiates infection in the upper respiratory tract (URT). Infected individuals are often asymptomatic, yet highly infectious and readily transmit virus. A therapy that restricts initial replication i...
Orellana-Rios, Jorge Verdaguer-Diaz, Juan I. Opazo, Gabriela Leong, Belinda C.S. Zett, Claudio Smith, R. Theodore Freund, K. Bailey
Published in
IDCases
To describe the ocurrence of Bartonella -associated neuroretinitis secondary to non-feline pet exposure, we retrospectively reviewed medical records and imaging from patients with a clinical and serologic diagnosis of Bartonella henselae (BH). Retinal imaging included color fundus photography, optical coherence tomography (OCT) and fluorescein angi...
Kanemasa, Toshiyuki Matsuzaki, Takanobu Koike, Katsumi Hasegawa, Minoru Suzuki, Tsutomu
Published in
Life sciences
Naldemedine is a peripherally acting μ-opioid receptor antagonists (PAMORAs) indicated for the treatment of opioid-induced constipation (OIC). We investigated the preventive effect of naldemedine on morphine-induced nausea and vomiting in ferrets and conducted a pharmacokinetic/pharmacodynamic (PK/PD) analysis. The antiemetic effect of naldemedine ...
Yeolekar, Leena R Guilfoyle, Kate Ganguly, Milan Tyagi, Parikshit Stittelaar, Koert J van Amerongen, Geert Dhere, Rajeev M BerlandaScorza, Francesco Mahmood, Kutub
Published in
Vaccine
During a pandemic, the availability of specific pathogen free chicken eggs is a major bottleneck for up-scaling response to the demand for influenza vaccine. This has led us to explore the use of Madin-Darby Canine Kidney (MDCK) cells for the manufacture of live attenuated influenza vaccine (LAIV) that provides production flexibility and speed. The...
Giner, Jacobo Villanueva-Saz, Sergio Alcover, María Magdalena Riera, Cristina Fisa, Roser Basurco, Asier Yzuel, Andrés Trotta, Michele Fani, Caterina Verde, María Teresa
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Published in
Veterinary parasitology, regional studies and reports
Leishmania infantum infection including treatment and follow up in domestic animals other than dogs and cats has not been described at this moment. This article describes the anti-Leishmania treatment and follow-up of a ferret (Mustela putorius furo) with leishmaniosis. A combined therapeutic protocol established for the patient, not yet approved f...
Nikiforuk, A. M. Tierny, K. Cutts, T. A. Kobasa, D. K. Theriault, S. S. Cook, B. W. M.
Published in
BMC Research Notes
ObjectivesMouse models have delivered variable recapitulation of Kyasanur Forest disease (KFD) pathology and consistently demonstrated neurological involvement which may be a limited feature of human disease. With the purpose of more accurately modelling human disease progression we infected several small-mammalian models: guinea pigs, hamsters and...
Yoshino, Mayuko Saito, Kengo Kawasaki, Kanji Horiike, Toshihide Shinmyo, Yohei Kawasaki, Hiroshi
Published in
Molecular Brain
In the white matter of the human cerebrum, the majority of cortico-cortical fibers are of short range, connecting neighboring cortical areas. U-fibers represent connections between neighboring areas and are located in the white matter immediately deep to the cerebral cortex. Using gyrencephalic carnivore ferrets, here we investigated the neurochemi...
Xu, Yifei
Published in
The Journal of infection
Giner, J. Basurco, A. Alcover, M.M. Riera, C. Fisa, R. López, R.A. Juan-Sallés, C. Verde, M.T. Fernández, A. Yzuel, Andrés
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Published in
Veterinary Parasitology, Regional Studies and Reports
• Ferrets have a potential epidemiological role as reservoir hosts of Leishmania infantum . • The main clinical sign of the disease was papular dermatitis lesion. • Clinicopathological findings were elevation of hepatic parameters, hypergammaglobulinemia with gammapathy polyclonal. • The presence of the parasite was detected by PCR in blood samples...
Hallman, Ruth Mackenzie Brandão, João
Published in
The veterinary clinics of North America. Exotic animal practice
Radiographs can be used to easily visualize common types of urinary calculi in all parts of the urinary tract. Positive-contrast excretory urography and cystourethrography are sensitive to diseases within the ureters and urethra, most commonly obstruction. Ultrasound is widely available and noninvasive and can be used to evaluate renal architecture...
