The one health problem of azole resistance in Aspergillus fumigatus: current insights and future research agenda
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status: published
Intrinsic disorder is an essential characteristic of components in the conserved circadian circuit
Published in Cell Communication and Signaling
IntroductionThe circadian circuit, a roughly 24 h molecular feedback loop, or clock, is conserved from bacteria to animals and allows for enhanced organismal survival by facilitating the anticipation of the day/night cycle. With circadian regulation reportedly impacting as high as 80% of protein coding genes in higher eukaryotes, the protein-based ...
Household medication safety practices during the COVID-19 pandemic: a descriptive qualitative study protocol
Introduction Those who are staying at home and reducing contact with other people during the COVID-19 pandemic are likely to be at greater risk of medication-related problems than the general population. This study aims to explore household medication practices by and for this population, identify practices that benefit or jeopardise medication saf...
Non-Invasive Quantitative Muscle Fatigue Estimation Based on Correlation Between sEMG Signal and Muscle Mass
Muscle fatigue is required to be assessed in real-time to maintain the best physical condition, especially for sports and rehabilitation areas. In recent years, numerous studies proposed muscle fatigue estimation methods with non-invasive surface electromyography (sEMG). However, the previous approaches were limited to discerning whether muscle fat...
Convolutional Neural Network Classifies Pathological Voice Change in Laryngeal Cancer with High Accuracy
Voice changes may be the earliest signs in laryngeal cancer. We investigated whether automated voice signal analysis can be used to distinguish patients with laryngeal cancer from healthy subjects. We extracted features using the software package for speech analysis in phonetics (PRAAT) and calculated the Mel-frequency cepstral coefficients (MFCCs)...
On the seasonal and sub-seasonal factors influencing East China tropical cyclone landfall
To date it has proved difficult to make seasonal forecasts of tropical cyclones, particularly for landfall and in East China specifically. This study examines sources of predictability for the number of landfalling typhoons in East China on seasonal (June–October) and sub‐seasonal time scales. East China landfall count is shown to be independent of...
The Cytokinesis-Block Micronucleus Assay on Human Isolated Fresh and Cryopreserved Peripheral Blood Mononuclear Cells
Published in Journal of Personalized Medicine
The cytokinesis-block micronucleus (CBMN) assay is a standardized method used for genotoxicity studies. Conventional whole blood cultures (WBC) are often used for this assay, although the assay can also be performed on isolated peripheral blood mononuclear cell (PBMC) cultures. However, the standardization of a protocol for the PBMC CBMN assay has ...
Discovery of rare variants associated with blood pressure regulation trhough meta-analaysis of 1.3 million individuals
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Genetic studies of blood pressure (BP) to date have mainly analyzed common variants (minor allele frequency, MAF > 0.05). In a meta-analysis of up to >1.3 million participants, we discovered 106 new BP-associated genomic regions and 87 rare (MAF≤ 0.01) variant BP associations (P
Investigating the lack of main-sequence companions to massive Be stars
status: published
Nocturia in patients with cognitive dysfunction: a systematic review of the literature
Published in BMC Geriatrics
BackgroundThe objective of this study is to evaluate current literature on the association between cognitive dysfunction and nocturia.MethodsA systematic review following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement was conducted through MEDLINE, EMBASE and COCHRANE databases and completed in November 2019. ...
