Lefere, Sander Puengel, Tobias Hundertmark, Jana Penners, Christian Frank, Anna Katharina Guillot, Adrien de Muynck, Kevin Heymann, Felix Adarbes, Vanessa Defrêne, Evelyne
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Published in
Journal of hepatology
Peroxisome proliferator-activated receptors (PPARs) are essential regulators of whole-body metabolism, but also modulate inflammation in immune cells, notably macrophages. We compared the effects of selective PPAR agonists to those of the pan-PPAR agonist lanifibranor in non-alcoholic fatty liver disease (NAFLD), and studied isoform-specific effect...
Remmerie, Anneleen Martens, Liesbet Thoné, Tinne Castoldi, Angela Seurinck, Ruth Pavie, Benjamin Roels, Joris Vanneste, Bavo De Prijck, Sofie Vanhockerhout, Mathias
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Metabolic-associated fatty liver disease (MAFLD) represents a spectrum of disease states ranging from simple steatosis to non-alcoholic steatohepatitis (NASH). Hepatic macrophages, specifically Kupffer cells (KCs), are suggested to play important roles in the pathogenesis of MAFLD through their activation, although the exact roles played by these c...
Schaapman, Jelte J; Tushuizen, Maarten E; Coenraad, Minneke J; 127095; Lamb, Hildo J;
Nonalcoholic fatty liver disease (NAFLD) is a common cause of chronic liver disease in the world, affecting more than 25% of the adult population. NAFLD covers a spectrum including simple steatosis, in which lipid accumulation in hepatocytes is the predominant histological characteristic, and nonalcoholic steatohepatitis (NASH), which is characteri...
Nicolaou, O Kousios, A Sokratous, K Potamiti, L Koniali, L Neophytou, G Papacharalampous, R Zanti, M Ioannou, K Hadjisavvas, A
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AIM: Alport syndrome (AS) is the second most common hereditary kidney disease caused by mutations in collagen IV genes. Patients present with microhaematuria that progressively leads to proteinuria and end stage renal disease. Currently, no specific treatment exists for AS. Using mass spectrometry based proteomics, we aimed to detect early alterati...
Mishra, Mudit; Muthuramu, Ilayaraja; Kempen, Herman; De Geest, Bart; 5329;
Therapeutic interventions with proven efficacy in heart failure with reduced ejection fraction (HFrEF) have been unsuccessful in heart failure with preserved ejection fraction (HFpEF). The modifiable risk factor with the greatest impact on the development of HFpEF is hypertension. The objectives of this study were to establish a murine model of HFp...
Vacca, M Leslie, J Virtue, S Lam, BYH Govaere, O Tiniakos, D Snow, S Davies, S Petkevicius, K Tong, Z
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Non-alcoholic steatohepatitis (NASH) is characterized by lipotoxicity, inflammation and fibrosis, ultimately leading to end-stage liver disease. The molecular mechanisms promoting NASH are poorly understood, and treatment options are limited. Here, we demonstrate that hepatic expression of bone morphogenetic protein 8B (BMP8B), a member of the tran...
Wang, Xixin; 107649; Giusti, Arianna; 114882; Ny, Annelii; 44018; de Witte, Peter A; 19564;
With the aim to explore the possibility to generate a zebrafish model of renal fibrosis, in this study the fibrogenic renal effect of aristolochic acid I (AAI) after immersion was assessed. This compound is highly nephrotoxic able to elicit renal fibrosis after exposure of rats and humans. Our results reveal that larval zebrafish at 15 days dpf (da...
Verboom, Lien Martens, Arne Priem, Dario Hoste, Esther Sze, Mozes Vikkula, Hanna Van Hove, Lisette Voet, Sofie Roels, Jana Maelfait, Jonathan
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Published in
Cell reports
Inflammatory signaling pathways are tightly regulated to avoid chronic inflammation and the development of disease. OTULIN is a deubiquitinating enzyme that controls inflammation by cleaving linear ubiquitin chains generated by the linear ubiquitin chain assembly complex. Here, we show that ablation of OTULIN in liver parenchymal cells in mice caus...
Mendichovszky, Iosif Pullens, Pim Dekkers, Ilona Nery, Fabio Bane, Octavia Pohlmann, Andreas de Boer, Anneloes Ljimani, Alexandra Odudu, Aghogho Buchanan, Charlotte
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Published in
Magma (New York, N.Y.)
The potential of renal MRI biomarkers has been increasingly recognised, but clinical translation requires more standardisation. The PARENCHIMA consensus project aims to develop and apply a process for generating technical recommendations on renal MRI. A task force was formed in July 2018 focused on five methods. A draft process for attaining consen...
Sepanlou, SG Safiri, S Bisignano, C Ikuta, KS Merat, S Saberifiroozi, M Poustchi, H Tsoi, D Colombara, DV Abdoli, A
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Background Cirrhosis and other chronic liver diseases (collectively referred to as cirrhosis in this paper) are a major cause of morbidity and mortality globally, although the burden and underlying causes differ across locations and demographic groups. We report on results from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2...
