Demuytere, Jesse Ceelen, Wim Van Dorpe, Jo Hoorens, Anne
Published in
Experimental and molecular pathology
Recent insights have implicated mesothelial-to-mesenchymal transition (MMT) as a mechanism by which mesothelial cells can transdifferentiate into cancer-associated fibroblasts (CAFs) in several cancers metastasizing to the peritoneum. However, this was not evaluated extensively in colorectal cancer. We examined the presumed mesothelial origin of CA...
Chelladurai, P Dabral, S Basineni, SR Chen, C-N Schmoranzer, M Bender, N Feld, C Noetzold, RR Dobreva, G Wilhelm, J
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Pharmacological modulation of class I histone deacetylases (HDAC) has been evaluated as a therapeutic strategy for pulmonary hypertension (PH) in experimental models of PH. However, information of their expression, regulation and transcriptional targets in human PH and the therapeutic potential of isoform-selective enzyme modulation are lacking. Co...
Ceelen, Wim Ramsay, Robert G. Narasimhan, Vignesh Heriot, Alexander G. De Wever, Olivier
Peritoneal metastasis (PM) occurs in approximately one in four colorectal cancer (CRC) patients. The pathophysiology of colorectal PM remains poorly characterized. Also, the efficacy of current treatment modalities, including surgery and intraperitoneal (IP) delivery of chemotherapy, is limited. Increasingly, therefore, efforts are being developed ...
Mammadova, Aysel; Carels, Carine EL; 13547; Zhou, Jie; Gilissen, Christian; Helmich, Maria PAC; Bian, Zhuan; Zhou, Huiqing; Von den Hoff, Johannes W;
Orofacial clefts (OFCs) are the most frequent craniofacial birth defects. An orofacial cleft (OFC) occurs as a result of deviations in palatogenesis. Cell proliferation, differentiation, adhesion, migration and apoptosis are crucial in palatogenesis. We hypothesized that deregulation of these processes in oral keratinocytes contributes to OFC. We p...
van der Helm, Danny; Barnhoorn, Marieke C; de Jonge-Muller, Eveline SM; Molendijk, Ilse; Hawinkels, Luuk JAC; Coenraad, Minneke J; 127095; van Hoek, Bart; Verspaget, Hein W;
Chronic liver injury leads to the accumulation of myofibroblasts resulting in increased collagen deposition and hepatic fibrogenesis. Treatments specifically targeting fibrogenesis are not yet available. Mesenchymal stromal cells (MSCs) are fibroblast-like stromal (stem) cells, which stimulate tissue regeneration and modulate immune responses. In t...
Nagaraju, Chandan K; 85839; Dries, Eef; 72461; Gilbert, Guillaume; 103486; Abdesselem, Mouna; 109992; Wang, Nan; Amoni, Matthew; 115377; Driesen, Ronald B; Sipido, Karin R; 11695;
After myocardial infarction, resident fibroblasts (Fb) differentiate towards myofibroblasts (MyoFb), generating the scar tissue and the interstitial fibrosis seen in the adjacent myocardium. Fb and MyoFb have the potential to interact with cardiac myocytes (CMs) but insight into the phenotype-specific role and mode of interaction is still incomplet...
Owen, TJ Harding, SE
Tissue engineering is a complex field where the elements of biology and engineering are combined in an attempt to recapitulate the native environment of the body. Tissue engineering has shown one thing categorically; that the human body is extremely complex and it is truly a difficult task to generate this in the lab. There have been varied attempt...
Distler, O Highland, KB Gahlemann, M Azuma, A Fischer, A Mayes, MD Raghu, G Sauter, W Girard, M Alves, M
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BACKGROUND: Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. Nintedanib, a tyrosine kinase inhibitor, has been shown to have antifibrotic and antiinflammatory effects in preclinical models of systemic sclerosis and ILD. METHODS: We conducted a randomized, double...
Doglioni, Ginevra; 120236; Parik, Sweta; Fendt, Sarah-Maria; 86131;
Metastasis formation is the leading cause of death in cancer patients. Thus, understanding and targeting this process is an unmet need. Crucial steps during the establishment of metastases include the (pre)metastatic niche formation. This process relies on the interaction of the primary tumor with the environment of distant organs (premetastatic ni...
Zhang, Shuchen Bell, Emma Zhi, Huihan Brown, Sarah Imran, Siti A. M. Azuara, Véronique Cui, Wei
Published in
Stem Cell Research & Therapy
BackgroundSox2 is a well-established pluripotent transcription factor that plays an essential role in establishing and maintaining pluripotent stem cells (PSCs). It is also thought to be a linage specifier that governs PSC neural lineage specification upon their exiting the pluripotent state. However, the exact role of SOX2 in human PSCs was still ...