Development of resistance to FGFR inhibition in urothelial carcinoma via multiple pathways in vitro.
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Published in The Journal of pathology
Alterations of fibroblast growth factor receptors (FGFRs) are common in bladder and other cancers and result in disrupted signalling via several pathways. Therapeutics that target FGFRs have now entered the clinic, but, in common with many cancer therapies, resistance develops in most cases. To model this, we derived resistant sublines of two FGFR-...
