Beukema, Wouter Pasmans, Frank Van Praet, Sarah Ferri-Yáñez, Francisco Kelly, Moira Laking, Alexandra E Erens, Jesse Speybroeck, Jeroen Verheyen, Kris Lens, Luc
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Published in
Ecology letters
While epizootics increasingly affect wildlife, it remains poorly understood how the environment shapes most host-pathogen systems. Here, we employ a three-step framework to study microclimate influence on ectotherm host thermal behaviour, focusing on amphibian chytridiomycosis in fire salamanders (Salamandra salamandra) infected with the fungal pat...
Van den Bruel, Ann; 33205; Verbakel, Jan; 42064; Wang, Kay; Fleming, Susannah; Holtman, Gea; Glogowska, Margaret; Morris, Elizabeth; Edwards, George; Ismail, Fatene Abakar; Curtis, Kathryn;
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BACKGROUND: Current options for temperature measurement in children presenting to primary care include either electronic axillary or infrared tympanic thermometers. Non-contact infrared thermometers could reduce both the distress of the child and the risk of cross-infection. OBJECTIVES: The objective of this study was to compare the use of non-cont...
Van den Bruel, Ann Verbakel, Jan Wang, Kay Fleming, Susannah Holtman, Gea Glogowska, Margaret Morris, Elizabeth Edwards, George Abakar Ismail, Fatene Curtis, Kathryn
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Published in
Health technology assessment (Winchester, England)
General practitioners commonly measure children’s temperature using a thermometer placed in the armpit or ear canal. New ’non-contact’ thermometers use infrared light to measure temperature without touching the child. They are easy to use and there is no risk of passing on infections. However, we do not know how well they measure temperature compar...
Hogan, A Winskill, P Ghani, A
Background: The RTS,S/AS01 vaccine against P. falciparum malaria infection completed phase 3 trials in 2014, and demonstrated efficacy against clinical malaria of approximately 36% over 4 years for a 4-dose schedule in children aged 5–17 months. Pilot vaccine implementation has recently begun in three African countries. If the pilots demonstrate bo...
Kawashima, Masahiro Bensaad, Karim Zois, Christos E. Barberis, Alessandro Bridges, Esther Wigfield, Simon Lagerholm, Christoffer Dmitriev, Ruslan I. Tokiwa, Mariko Toi, Masakazu
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Published in
Cancer & Metabolism
BackgroundHumans produce heat through non-shivering thermogenesis, a metabolic process that occurs in inducible beige adipocytes expressing uncoupling protein 1 (UCP1). UCP1 dissipates the proton gradient of the mitochondrial inner membrane and converts that energy into heat. It is unclear whether cancer cells can exhibit autonomous thermogenesis. ...
Giovanetti, Marta; Faria, Nuno Rodrigues; Lourenco, Jose; de Jesus, Jaqueline Goes; Xavier, Joilson; Claro, Ingra Morales; Kraemer, Moritz UG; Fonseca, Vagner; Dellicour, Simon; 105548; Theze, Julien;
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Zika virus (ZIKV) has caused an explosive epidemic linked to severe clinical outcomes in the Americas. As of June 2018, 4,929 ZIKV suspected infections and 46 congenital syndrome cases had been reported in Manaus, Amazonas, Brazil. Although Manaus is a key demographic hub in the Amazon region, little is known about the ZIKV epidemic there, in terms...
Raymond, M Gibani, MM Day, NPJ Cheah, PY
Typhoidal Salmonella is a major global problem affecting more than 12 million people annually. Controlled human infection models (CHIMs) in high-resource settings have had an important role in accelerating the development of conjugate vaccines against Salmonella Typhi. The typhoidal Salmonella model has an established safety profile in over 2000 vo...
Jin, C Gibani, MM Pennington, SH Liu, X Ardrey, A Aljayyoussi, G Moore, M Angus, B Parry, CM Biagini, GA
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Background The treatment of enteric fever is complicated by the emergence of antimicrobial resistant Salmonella Typhi. Azithromycin is commonly used for first-line treatment of uncomplicated enteric fever, but the response to treatment may be sub-optimal in some patient groups when compared with fluoroquinolones. Methods We performed an analysis of...
Ehichioya, Deborah U; Dellicour, Simon; 105548; Pahlmann, Meike; Rieger, Toni; Oestereich, Lisa; Becker-Ziaja, Beate; Cadar, Daniel; Ighodalo, Yemisi; Olokor, Thomas; Omomoh, Emmanuel;
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Lassa virus is genetically diverse with several lineages circulating in West Africa. This study aimed at describing the sequence variability of Lassa virus across Nigeria and inferring its spatiotemporal evolution. We sequenced and isolated 77 Lassa virus strains from 16 Nigerian states. The final data set, including previous works, comprised metad...
Chiaravalloti-Neto, Francisco da Silva, Rafael Alves Zini, Nathalia da Silva, Gislaine Celestino Dutra da Silva, Natal Santos Parra, Maisa Carla Pereira Dibo, Margareth Regina Estofolete, Cassia Fernanda Fávaro, Eliane Aparecida Dutra, Karina Rocha
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Published in
BMC Infectious Diseases
BackgroundSão José do Rio Preto is one of the cities of the state of São Paulo, Brazil, that is hyperendemic for dengue, with the presence of the four dengue serotypes.Objectives: to calculate dengue seroprevalence in a neighbourhood of São José do Rio Preto and identify if socioeconomic and demographic covariates are associated with dengue seropos...
