Chiaravalloti-Neto, Francisco da Silva, Rafael Alves Zini, Nathalia da Silva, Gislaine Celestino Dutra da Silva, Natal Santos Parra, Maisa Carla Pereira Dibo, Margareth Regina Estofolete, Cassia Fernanda Fávaro, Eliane Aparecida Dutra, Karina Rocha
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Published in
BMC Infectious Diseases
BackgroundSão José do Rio Preto is one of the cities of the state of São Paulo, Brazil, that is hyperendemic for dengue, with the presence of the four dengue serotypes.Objectives: to calculate dengue seroprevalence in a neighbourhood of São José do Rio Preto and identify if socioeconomic and demographic covariates are associated with dengue seropos...
Wang, X Tang, S Wu, J Xiao, Y Cheke, RA
Background China’s Guangdong Province experienced a major dengue outbreak in 2014. Here we investigate if the weather conditions contributing to the outbreak can be elucidated by multi-scale models. Methods A multi-scale modelling framework, parameterized by available weather, vector and human case data, was used to examine the integrative effect o...
Stapels, DAC Hill, PWS Westermann, AJ Fisher, RA Thurston, TL Saliba, A-E Blommestein, I Vogel, J Helaine, S
Many bacterial infections are hard to treat and tend to relapse, possibly due to the presence of antibiotic-tolerant persisters. In vitro, persister cells appear to be dormant. After uptake of Salmonella species by macrophages, nongrowing persisters also occur, but their physiological state is poorly understood. In this work, we show that Salmonell...
Gibani, MM Voysey, M Jin, C Jones, C Thomaides-Brears, H Jones, E Baker, P Morgan, M Simmons, A Gordon, MA
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Background Shedding of Salmonella Typhi or Paratyphi in the stool or urine leads to contamination of food or water, which is a prerequisite for transmission of enteric fever. Currently, there are limited data on the effect of vaccination or prior exposure on stool shedding. Methods Six Salmonella Typhi or Paratyphi human challenge studies were cond...
Verbakel, Jan Y Lemiengre, Marieke De Burghgraeve, Tine De Sutter, An Aertgeerts, Bert Bullens, Dominique MA Shinkins, Bethany Van den Bruel, Ann Buntinx, Frank
Objective: Acute infection is the most common presentation of children to hospital. A minority of these infections are serious, but early recognition and adequate management are essential. We aimed to develop improved tools to assess children attending ambulatory hospital care, integrating clinical features with point-of-care C reactive protein (CR...
Dobinson, HC Gibani, MM Jones, C Thomaides-Brears, HB Voysey, M Darton, TC Waddington, CS Campbell, D Milligan, I Zhou, L
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Background. To expedite the evaluation of vaccines against paratyphoid fever, we aimed to develop the first human challenge model of Salmonella enterica serovar Paratyphi A infection. Methods. Two groups of 20 participants underwent oral challenge with S. Paratyphi A following sodium bicarbonate pretreatment at 1 of 2 dose levels (group 1: 1–5 × 10...
Filippitzi, Maria-Eleni Goumperis, T Robinson, T Saegerman, C
As part of the Emerging Risk Identification (ERI) activities of the European Food Safety Authority (EFSA), a literature search was conducted to identify the microbiological agents transmitted between livestock animals and humans that have been suggested as having emerged between 2007 and 2015 in peer-reviewed scientific literature published during ...
Phillips, Robert S Sung, Lillian Amman, Roland A Riley, Richard D Castagnola, Elio Haeusler, Gabrielle M Klaassen, Robert Tissing, Wim JE Lehrnbecher, Thomas Chisholm, Julia
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Background: Risk-stratified management of fever with neutropenia (FN), allows intensive management of high-risk cases and early discharge of low-risk cases. No single, internationally validated, prediction model of the risk of adverse outcomes exists for children and young people. An individual patient data (IPD) meta-analysis was undertaken to dev...
Phillips, Robert S Bhuller, Kaljit Sung, Lillian Ammann, Roland A Tissing, Wim JE Lehrnbecher, Thomas Stewart, Lesley A PCNICC Collaboration, on behalf of the Bauters, Tieneke Laureys, Genevieve
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Gibani, MM Jin, C Darton, TC Pollard, AJ
Invasive Salmonella disease in Africa is a major public health concern. With evidence of the transcontinental spread of the Salmonella Typhi H58 haplotype, improved estimates of the burden of infection and understanding of the complex interplay of factors affecting disease transmission are needed to assist with efforts aimed at disease control. In ...
