Bui, Minh Zebaze, Roger Li, Shuai Hopper, John L Bjørnerem, Åshild
Published in
JBMR plus
It is not known whether the relationships of lean mass (LM) and fat mass (FM) with bone microarchitecture and geometry are causal and/or are because of confounders, including familial confounders arising from genetic and environment effects shared by relatives. We tested the hypotheses that: (i) LM is associated with cortical bone traits, (ii) FM i...
Luo, Jin Lee, Raymond YW
Published in
JBMR Plus
Obesity and osteoporotic‐related fractures are two common public health problems, although it is unclear how obesity affects the risk of vertebral fractures. The purpose of this study was to examine the association between different measures of obesity and the risk of vertebral fracture, and to establish the various clinical factors that can predic...
Marini, S Merino, J Montgomery, BE Malik, R Sudlow, CL Dichgans, M Florez, JC Rosand, J Gill, D Anderson, CD
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OBJECTIVE: To systematically investigate causal relationships between obesity and cerebrovascular disease and the extent to which hypertension and hyperglycemia mediate the effect of obesity on cerebrovascular disease. METHODS: We used summary statistics from genome-wide association studies for body mass index (BMI), waist-to-hip ratio (WHR), and m...
Wilson, Laura A. B. De Groote, Isabelle Humphrey, Louise T.
Objectives Age-degenerative features of the metatarsals are poorly known despite the importance of metatarsal bone properties for investigating mobility patterns. We assessed the role of habitual activity in shaping the patterning and magnitude of sexual dimorphism in age-related bone loss in the hallucal metatarsal. Materials and methods Cross-sec...
Mauer, Jan Sindelar, Miriam Despic, Vladimir Guez, Théo Hawley, Ben R. Vasseur, Jean-Jacques Rentmeister, Andrea Gross, Steven S. Pellizzoni, Livio Debart, Françoise
...
Published in
Nature Chemical Biology
Two different methylation states of the adenosine adjacent to the snRNA cap are found in the biogenesis process of snRNAs, Am and m6Am, whose levels are regulated by FTO and are related to alternative pre-mRNA splicing.
Augustijn, Mireille Di Biase, Maria Zalesky, Andrew Van Acker, Lore De Guchtenaere, Ann D’Hondt, Eva Lenoir, Matthieu Deconinck, Frederik Caeyenberghs, Karen
Background: Previous studies suggest that obesity (OB) is associated with disrupted brain network organization; however, it remains unclear whether these differences already exist during childhood. Moreover, it should be investigated whether deviant network organization may be susceptible to treatment. Methods: Here, we compared the structural conn...
Dandona, Paresh; Mathieu, Chantal; 9139; Phillip, Moshe; Hansen, Lars; Tschoepe, Diethelm; Thoren, Fredrik; Xu, John; Langkilde, Anna Maria;
OBJECTIVE: This study evaluated the long-term safety and efficacy of dapagliflozin as an adjunct to adjustable insulin in patients with type 1 diabetes and inadequate glycemic control. RESEARCH DESIGN AND METHODS: DEPICT-1 (Dapagliflozin Evaluation in Patients With Inadequately Controlled Type 1 Diabetes) was a randomized (1:1:1), double-blind, pla...
Ibáñez Vodnizza, Sebastián E Nurmohamed, Michael T Visman, Ingrid M van Denderen, J Christiaan Lems, Willem F Jaime, Francisca van der Horst-Bruinsma, Irene E
Published in
The Journal of rheumatology
Our main objective was to assess the relationship between body composition (BC) and response to tumor necrosis factor-α (TNF-α) blocker treatment in patients with ankylosing spondylitis (AS). Our secondary objective was to evaluate the change of BC after treatment, accounting for sex and age. All included patients fulfilled the modified New York cr...
Logan, Karen M Gale, Chris Hyde, Matthew J Santhakumaran, Shalini Modi, Neena
Published in
Archives of disease in childhood. Fetal and neonatal edition
IDM have significantly greater adiposity in comparison with NIDM. These findings are justification for studies to determine whether measures to reduce infant adiposity will improve later health.
Sioen, I. Lust, E. De Henauw, S. Moreno, L. A. Jiménez-Pavón, D.
Published in
Calcified Tissue International
More clarification on the associations between children’s and adolescents’ lean and fat mass (LM and FM) on the one hand and their bone health on the other hand is needed, given the rising prevalence of overweight and obesity in this population. This systematic literature review aimed to describe the current evidence on these associations. Data sou...
