ZEB1 and ZEB2 are structurally related E-box binding homeobox transcription factors that induce epithelial to mesenchymal transitions during development and disease. As such, they regulate cancer cell invasion, dissemination and metastasis of solid tumors. In addition, their expression is associated with the gain of cancer stem cell properties and ...
Armadillo-repeat-containing protein 8 (Armc8) belongs to the family of armadillo-repeat containing proteins, which have been found to be involved in diverse cellular functions including cell-cell contacts and intracellular signaling. By comparative analyses of armadillo repeat protein structures and genomes from various premetazoan and metazoan spe...
Ewing's sarcoma (ES) is a rare, highly malignant anaplastic stem cell tumor. Histologically, the tumor consists of uniform densely packed small monomorphic cells with round nuclei. The typical appearance at hematoxylin and eosin (H&E) staining is small blue round cells without any matrix formation. On conventional radiography, ES typically presents...
Lytic polysaccharide monooxygenases (LPMOs) are copper-dependent enzymes that oxidatively cleave many of nature's most recalcitrant polysaccharides by acting on the C1- and/or C4-carbon of the glycosidic bond. Here, the results of an extensive mutagenesis study on three LPMO representatives, Phanerochaete chrysosporium LPMO9D (C1-oxidizer), Neurosp...
While apical growth in plants initiates upon seed germination, radial growth is only primed during early ontogenesis in procambium cells and activated later by the vascular cambium. Although it is not known how radial growth is organized and regulated in plants, this system resembles the developmental competence observed in some animal systems, in ...
Experiences of family members are often overlooked in social research on gender transitions. The current article aims to address this gap by considering the experiences of partners during a gender transition, approaching this topic through role theory and the concepts of role ambiguity and role conflict. Seventeen partners and former partners were ...
The present report deals with the syntheses, crystal structures, dc/ac magnetic properties and DFT/ab initio CASSCF calculations of two isomorphous bis((1):(2):(2)-acetate)GdIII2/DyIII2 compounds of the formula [LnIII2L(2)(acetate)(4)(MeOH)(2)] (1, Ln = Gd; 2, Ln = Dy), where HL is (E)-N-(3-ethoxysalicylidene)acetohydrazide. The two lanthanide(iii)...
Phenol and its derivatives constitute a class of highly toxic xenobiotics that pollute both river and groundwater. Here, we use a highly stable enzyme-based in vitro biosensing scaffold to develop a chip-based environmental diagnostic for in situ accurate, direct detection of phenol with selectively down to 10 ppb. Mesoporous silica nanoparticles (...
The present report deals with the syntheses, crystal structures, dc/ac magnetic properties and DFT/ab initio CASSCF calculations of two isomorphous bis((1):(2):(2)-acetate)GdIII2/DyIII2 compounds of the formula [LnIII2L(2)(acetate)(4)(MeOH)(2)] (1, Ln = Gd; 2, Ln = Dy), where HL is (E)-N-(3-ethoxysalicylidene)acetohydrazide. The two lanthanide(iii)...
