Huang, Qin Gong, Meng Tan, Tuantuan Lin, Yunong Bao, Yan Fan, Cuifang
Published in
Nanoscale Research Letters
Exosomes derived from human umbilical cord mesenchymal stem cells (hucMSCs) expressing microRNAs have been highlighted in human diseases. However, the detailed molecular mechanism of hucMSCs-derived exosomal miR-18b-3p on preeclampsia (PE) remains further investigation. We aimed to investigate the effect of exosomes and miR-18b-3p/leptin (LEP) on o...
Su, Yuhua Liu, Yajing Ma, Chao Guan, Chunxiao Ma, Xiufen Meng, Shan
Published in
Journal of Orthopaedic Surgery and Research
BackgroundLong non-coding RNA heart and neural crest derivatives expressed 2-antisense RNA 1 (HAND2-AS1) was found to be elevated in rheumatoid arthritis (RA) fibroblast-like synoviocytes (RA-FLSs). However, whether HAND2-AS1 functions as an exosomal lncRNA related to mesenchymal stem cells (MSCs) in RA progression is unknown.MethodsThe expression ...
Weber, Birte Franz, Niklas Marzi, Ingo Henrich, Dirk Leppik, Liudmila
Published in
European Journal of Trauma and Emergency Surgery
Due to the continued high incidence and mortality rate worldwide, there is a need to develop new strategies for the quick, precise, and valuable recognition of presenting injury pattern in traumatized and poly-traumatized patients. Extracellular vesicles (EVs) have been shown to facilitate intercellular communication processes between cells in clos...
Liu, Wen-zhao Ma, Zhan-jun Li, Jie-ru Kang, Xue-wen
Published in
Stem Cell Research & Therapy
Spinal cord injury (SCI) often leads to serious motor and sensory dysfunction of the limbs below the injured segment. SCI not only results in physical and psychological harm to patients but can also cause a huge economic burden on their families and society. As there is no effective treatment method, the prevention, treatment, and rehabilitation of...
Chen, Tengfei Liu, Yali Chen, Jun Zheng, Huifei Chen, Qiuyun Zhao, Jun
Published in
Thoracic cancer
Non-small cell lung cancer (NSCLC) is one of the most malignant cancers worldwide and its pathogenesis is not completely clear. In this study, we explored the functions and mechanisms of exosomes transferring miR-3180-3p in NSCLC progression. The expression levels of miR-3180-3p in NSCLC tissues and paracarcinoma tissues was obtained from the GEO d...
Venkat, Poornima Cui, Chengcheng Chen, Zhili Chopp, Michael Zacharek, Alex Landschoot-Ward, Julie Culmone, Lauren Yang, Xiao-Ping Xu, Jiang Chen, Jieli
...
Published in
Translational stroke research
Cardiac complications post-stroke are common, and diabetes exacerbates post-stroke cardiac injury. In this study, we tested whether treatment with exosomes harvested from human umbilical cord blood derived CD133+ cells (CD133+Exo) improves cardiac function in type 2 diabetes mellitus (T2DM) stroke mice. Adult (3-4 m), male, BKS.Cg-m+/+Leprdb/J (db/...
Wang, Lanfang Shi, Zhexi Wang, Xinyan Mu, Shu Xu, Xiaoyan Shen, Li Li, Ping
Published in
European journal of nutrition
Bovine milk exosomes, which are enriched with microRNAs (miRNAs) and proteins, regulate immune response and growth. In the present study, we aimed to assess the protective effects of bovine milk exosomes against oxidative stress of intestinal crypt epithelial cells (IEC-6). Bovine milk exosomes were isolated and characterized. To assess the protect...
Schultz, Iago Carvalho Bertoni, Ana Paula Santin Wink, Márcia Rosângela
Published in
Stem Cell Reviews and Reports
In the end of 2019 COVID-19 emerged as a new threat worldwide and this disease present impaired immune system, exacerbated production of inflammatory cytokines, and coagulation disturbs. Mesenchymal stem cell (MSC) derived extracellular vesicles (EVs) have emerged as a therapeutic option due to its intrinsic properties to alleviate inflammatory res...
Pei, Yujiao Ge, Yonghao Zhang, Xiaoru Li, Ying
Published in
Microchimica Acta
A cathodic photoelectrochemical sensor has been developed for the determination of exosomes, based on a dual-signal reduction strategy. A heterostructure of NiO/BiOI/Au NP/CdSe was synthesized as a photoelectrochemical sensing interface, which is able to suppress the recombination of electron-hole pairs and produce a higher photocurrent. The obtain...
Shi, Jie Zhao, Yu-Chen Niu, Zhi-Fang Fan, Hao-Jun Hou, Shi-Ke Guo, Xiao-Qin Sang, Lu Lv, Qi
Published in
World Journal of Stem Cells
Mesenchymal stem cells (MSCs) are self-renewing, multipotent cells that could differentiate into multiple tissues. MSC-based therapy has become an attractive and promising strategy for treating human diseases through immune regulation and tissue repair. However, accumulating data have indicated that MSC-based therapeutic effects are mainly attribut...
