Gámez-Valero, Ana Campdelacreu, Jaume Vilas, Dolores Ispierto, Lourdes Reñé, Ramón Álvarez, Ramiro Armengol, M. Pilar Borràs, Francesc E. Beyer, Katrin
Published in
Translational Neurodegeneration
BackgroundBecause of the increasing life expectancy in our society, aging-related neurodegenerative disorders are one of the main issues in global health. Most of these diseases are characterized by the deposition of misfolded proteins and a progressive cognitive decline. Among these diseases, Alzheimer’s disease (AD) and dementia with Lewy bodies ...
Reif, Shimon Elbaum Shiff, Yaffa Golan-Gerstl, Regina
Published in
Journal of Translational Medicine
BackgroundBreastfeeding is the ideal source of infant nutrition. Human milk consists not only of nutrients but also biologically active components. Among these latter compounds, exosomes contain proteins, lipids, mRNAs and miRNAs.MethodsTo elucidate the biological effects of milk-derived exosomes (MDEs) on normal colonic epithelial cells compared t...
Park, Kyong-Su Bandeira, Elga Shelke, Ganesh V. Lässer, Cecilia Lötvall, Jan
Published in
Stem Cell Research & Therapy
After the initial investigations into applications of mesenchymal stem cells (MSCs) for cell therapy, there was increased interest in their secreted soluble factors. Following studies of MSCs and their secreted factors, extracellular vesicles (EVs) released from MSCs have emerged as a new mode of intercellular crosstalk. MSC-derived EVs have been i...
Mao, Yu Wang, Yimin Dong, Lixin Zhang, Yunjie Zhang, Yanqiu Wang, Chao Zhang, Qiang Yang, Sen Cao, Liyan Zhang, Xinyuan
...
Published in
Journal of Experimental & Clinical Cancer Research
BackgroundIn cancer progression, hypoxia, or low oxygen tension, is a major regulator of tumor aggressiveness and metastasis. However, how cancer cells adapt to the hypoxia and communicate with other mesenchymal cells in microenvironment during tumor development remains to be elucidated. Here, we investigated the involvement of exosomes in modulati...
Dai, Wenjuan Wang, Yilin Yang, Tianxiao Wang, Jing Wu, Weicheng Gu, Jianxin
Published in
Cell Communication and Signaling
BackgroundC-Type Lectin Domain Family 3 Member B (CLEC3B), is down-regulated in serum and tumor tissues in different cancers including hepatocellular carcinoma (HCC). However, the functions of CLEC3B in HCC remains elucidated. The aim of this study is to analyze the roles of CLEC3B in HCC.MethodsThe expression of genes was evaluated by immunohistoc...
Li, Na Zhao, Lu Wei, Yankai Ea, Vicki L. Nian, Hong Wei, Ruihua
Published in
Stem Cell Research & Therapy
Exosomes, nanosized extracellular vesicles of 30–150 nm, are shed by almost all cell types. Bearing proteins, lipids, RNAs, and DNAs, exosomes have emerged as vital biological mediators in cell-to-cell communication, affecting a plethora of physiological and pathological processes. Particularly, mounting evidence indicates that immunologically acti...
Deng, Yiming Chen, Duanduan Gao, Feng Lv, Hong Zhang, Guojun Sun, Xuan Liu, Lian Mo, Dapeng Ma, Ning Song, Ligang
...
Published in
Journal of Biological Engineering
BackgroundMicroRNAs (miRNAs) are implicated in the progression of ischemic stroke (IS) and bone marrow-derived mesenchymal stem cells (BMSCs)-derived exosomes play a role in IS therapy. Herein we hypothesized that the BMSCs-derived exosomes containing overexpressed miR-138-5p could protect the astrocytes following IS involved with lipocalin 2 (LCN2...
Lee, Sang-Soo Won, Jong-Hoon Lim, Gippeum J. Han, Jeongran Lee, Ji Youn Cho, Kyung-Ok Bae, Young-Kyung
Published in
Cell Communication and Signaling
BackgroundExtracellular vesicles (EVs) play important roles in intercellular communication by delivering RNA, lipid, and proteins to neighboring or distant cells. Identification and classification of EVs secreted from diverse cell types are essential for understanding their signaling properties.MethodsIn this study, EVs from the culture media were ...
Hong, Pengyu Yang, Hao Wu, Yue Li, Kun Tang, Zhangui
Published in
Stem Cell Research & Therapy
Exosomes are extracellular membranous nanovesicles that mediate local and systemic intercellular communication by transporting proteins or nucleic acids (DNA and RNA) into target cells, thus altering the behaviors of recipient cells. Recent studies have revealed that these vesicles play a critical role in many biological functions, such as cell pro...
Ren, Ruixue Sun, Hua Ma, Cui Liu, Jiatao Wang, Hua
Published in
Cell & Bioscience
Colon-cancer-cell-derived exosomes (CDEs) are emerging mediators of tumorigenesis and serve as messengers of intercellular communication; however, whether the CDEs affect the proliferation of colon cancer cells themselves remains unknown. In the current study, the CDEs isolated from human colon cancer cell line SW480 and HCT116 showed a size range ...
