Davidson, Sean M Boulanger, Chantal M Aikawa, Elena Badimon, Lina Barile, Lucio Binder, Christoph J Brisson, Alain Buzas, Edit Emanueli, Costanza Jansen, Felix
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Published in
Cardiovascular research
Extracellular vesicles (EVs) are nanosized vesicles with a lipid bilayer that are released from cells of the cardiovascular system, and are considered important mediators of intercellular and extracellular communications. Two types of EVs of particular interest are exosomes and microvesicles, which have been identified in all tissue and body fluids...
Kong, Yao Zhan, Yongchi Chen, Daijuan Deng, Xixi Liu, Xinghui Xu, Tingting Wang, Xiaodong
Published in
BMC pregnancy and childbirth
Intrahepatic cholestasis of pregnancy (ICP) is strongly associated with an increased risk of adverse perinatal outcomes. Total bile acid (TBA) levels in the late second or third trimester are a major factor in the diagnosis. Here, we sought to establish the miRNA expression profile of plasm exosomes of ICP and identify possible biomarkers for the d...
Sen, Srijita Xavier, Joyal Kumar, Nitesh Ahmad, Mohammad Zaki Ranjan, Om Prakash
Published in
3 Biotech
Exosomes are nanosized (size ~ 30-150 nm) natural vesicular structures released from cells by physiological processes or pathological circumstances. Exosomes are growing in popularity as a result of their many benefits over conventional nanovehicles, including their ability to escape homing in the liver or metabolic destruction and their lack of un...
Mobahat, Mahsa Sadroddiny, Esmaeil Nooshabadi, Vajihe Taghdiri Ebrahimi-Barough, Somayeh Goodarzi, Arash Malekshahi, Ziba Veisi Ai, Jafar
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Cell and tissue banking
Parkinson disease (PD) is considered as one of the most worldwide neurodegenerative disorders. The major reasons associated to neurodegeneration process of PD pathogenesis are oxidative stress. Many studies reported that natural antioxidant molecules, especially, curcumin can suppress inflammatory pathways and preserve dopaminergic neurons damage i...
Mot, Yee Yik Moses, Emmanuel Jairaj Mohd Yusoff, Narazah Ling, King-Hwa Yong, Yoke Keong Tan, Jun Jie
Published in
Cellular and molecular neurobiology
Traumatic brain injury (TBI) could result in life-long disabilities and death. Though the mechanical insult causes primary injury, the secondary injury due to dysregulated responses following neuronal apoptosis and inflammation is often the cause for more detrimental consequences. Mesenchymal stromal cell (MSC) has been extensively investigated as ...
Lai, Chenteng Liao, Boyi Peng, Song Fang, Peng Bao, Nirong Zhang, Lei
Published in
Molecular and cellular biochemistry
MicroRNAs (miRs) are regulators of number of cellular process. miRs enclosed within exosomes can be crucial regulators of intercellular signalling and could be an important biomarker of various age-associated disorders. Role of exosomal enclosed miRs in osteoarthritis (OA) chondrocytes and synovial fibroblasts (SFBs) remains poorly studied. Here, w...
Yu, Ming Yun Jia, Hui Jie Zhang, Jing Ran, Guang He Liu, Yan Yang, Xiu Hong
Published in
International immunopharmacology
Macrophages are highly heterogeneous and plastic immune cells that play an important role in the fight against pathogenic microorganisms and tumor cells. After different stimuli, macrophages can polarize to the M1 phenotype to show a pro-inflammatory effect and the M2 phenotype to show an anti-inflammatory effect. The balance of macrophage polariza...
Zhao, Yaru Tang, Jiajia Jiang, Ke Liu, Shin-Yi Aicher, Alexandra Heeschen, Christopher
Published in
Biochimica et biophysica acta. Reviews on cancer
Pancreatic cancer is a lethal condition with a rising incidence and often presents at an advanced stage, contributing to abysmal five-year survival rates. Unspecific symptoms and the current lack of biomarkers and screening tools hamper early diagnosis. New technologies for liquid biopsies and their respective evaluation in pancreatic cancer patien...
Fan, Leilei Li, Weiwei Jiang, Hongsheng
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Biochemical genetics
Colorectal cancer (CRC) has been listed as the fourth deadly cancer. Circular RNA hsa_circRNA_001046, also termed as hsa_circ_0000395 (circ_0000395), has been shown to be upregulated in CRC. Nevertheless, the function of circ_0000395 in CRC progression is unclear. 42 CRC patients were enrolled in the study. Detection of circ_0000395 expression in t...
Dimik, Marko Abeysinghe, Pevindu Logan, Jayden Mitchell, Murray
Exosomes are nano-vesicles (30–150 nm) which may be useful as therapeutic delivery vehicles and as diagnostic biomarkers. Exosomes are produced naturally within the human body and therefore are not prone to immunogenicity effects which would otherwise destroy unelicited foreign bodies. Clinically, they have been regarded as ideal candidates for app...
