Salah, S To, Y H Khozouz, O Ismail, T Yaser, S Alnsour, A Shahin, O Sultan, I Abuhijlih, R Halalsheh, H
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Published in
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
Irinotecan and temozolomide (IT) is a widely used regimen for relapsed Ewing sarcoma (ES), although studies are largely limited to paediatric populations. We retrospectively reviewed paediatric (
Ye, Yu Qiu, Xiaoming Mei, Jixin He, Dongyun Zou, Ailing
Published in
The Journal of International Medical Research
A rare and highly malignant small round cell tumor, Ewing sarcoma/primitive neuroectodermal tumor (ES/PNET) usually occurs in the pelvis, long-axis bones, and femur. In contrast, extraosseous ES is more often found in the paraspinal region, limbs, and retroperitoneum, but is extremely rare in the stomach. We report a case of a 55-year-old woman who...
Huijskens, Sophie C Kroon, Petra S Gaze, Mark N Gandola, Lorenza Bolle, Stephanie Supiot, Stephane Abakay, Candan D Alexopoulou, Aikaterini Bokun, Jelena Chojnacka, Marzanna
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Published in
European journal of cancer (Oxford, England : 1990)
About 20% of children with solid tumours (ST) present with distant metastases (DM). Evidence regarding the use of radical radiotherapy of these DM is sparse and open for personal interpretation. The aim of this survey was to review European protocols and to map current practice regarding the irradiation of DM across SIOPE-affiliated countries. Radi...
Zheng, Chuanxi Zhou, Yong Luo, Yi Zhang, Hongying Tu, Chongqi Min, Li
Published in
Frontiers in pediatrics
Background: Ewing sarcoma is the second most common malignant bone tumor in children, but it rarely originates from extra-skeletal sites. The commonly involved sites of soft tissue include paravertebral spaces, lower extremities, the pelvis, head, and neck, while primary extra-skeletal Ewing sarcoma (EES) located in the genitals is extremely rare. ...
Sewell, Marisa A. Hulka, Frieda M. Zucker, Jacob P.
Published in
Annals of Pediatric Surgery
BackgroundPilonidal disease classically presents as an abscess or soft tissue swelling which classically occurs in the intergluteal cleft, just above the anus. Risk factors for this disease include obesity, prolonged sitting, and abundance of gluteal hair. Treatment options are extensive but most often include incision and drainage with antibiotic ...
Xu, Guijun Wu, Haixiao Xu, Yao Zhang, Yanting Lin, Feng Baklaushev, Vladimir P Chekhonin, Vladimir P Peltzer, Karl Wang, Xin Mao, Min
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Published in
Orthopaedic Surgery
Patients with chordoma, chondrosarcoma, Ewing sarcoma, and osteosarcoma showed homogenous and heterogenous clinicopathological characteristics, survival rates, and prognostic factors, which can potentially guide sarcoma‐specific prediction and treatments.
Chugh, Rashmi Ballman, Karla V Helman, Lee J Patel, Shreyaskumar Whelan, Jeremy S Widemann, Brigitte Lu, Yao Hawkins, Douglas S Mascarenhas, Leo Glod, John W
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Published in
Cancer
In preclinical Ewing sarcoma (ES) models, poly(adenosine diphosphate ribose) polymerase (PARP) inhibitors were identified as a potential therapeutic strategy with synergy in combination with cytotoxic agents. This study evaluated the safety and dosing of the PARP1/2 inhibitor niraparib (NIR) with temozolomide (TMZ; arm 1) or irinotecan (IRN; arm 2)...
Wang, Jie Fan, Yonggang Xia, Lei
Published in
Current oncology (Toronto, Ont.)
Up to now, an accurate nomogram to predict the lung metastasis probability in Ewing sarcoma (ES) at initial diagnosis is lacking. Our objective was to construct and validate a nomogram for the prediction of lung metastasis in ES patients. A total of 1157 patients with ES from the Surveillance, Epidemiology, and End Results (SEER) database were retr...
Jones, Robert Maleki, Zahra
Published in
Diagnostic cytopathology
Adamantinoma-like Ewing sarcoma (ALES) is a rare variant of Ewing sarcoma family of tumors (ESFTs). ALES is characterized by translocations of the EWSR1 (Ewing sarcoma breakpoint region 1) gene on chromosome 22, morphologic features of small round blue cell tumors with focal squamous differentiation, and a unique immunoprofile. Herein, we report a ...
Phanhthilath, Nikki Hakim, Sara Su, Catherine Liu, Andrea Subramonian, Divya Lesperance, Jacqueline Zage, Peter E
Published in
Investigational new drugs
Children with aggressive pediatric solid tumors have poor outcomes and novel treatments are needed. Pediatric solid tumors demonstrate aberrant expression and activity of the fibroblast growth factor receptor (FGFR) family, suggesting FGFR inhibitors may be effective therapeutic agents. AZD4547 is a multikinase inhibitor of the FGFR1-3 kinases, and...