Shiyanbola, Oyewale Nigdelioglu, Recep Dhall, Deepti González, Iván Warmke, Laura Schechter, Shula Choi, Won-Tak Hu, Shaomin Voltaggio, Lysandra Zhang, Yujie
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Ewing sarcoma (ES) is an uncommon mesenchymal neoplasm that typically develops as a bone mass, although up to 30% arise in extraskeletal sites. ES of the gastrointestinal (GI) and hepatobiliary tract is rare and may be misdiagnosed as other, more common neoplasms that occur in these sites. However, the correct classification of extraskeletal ES is ...
Ruzanov, Peter Evdokimova, Valentina Pachva, Manideep Minkovich, Alon Zhang, Zhenbo Langman, Sofya Gassmann, Hendrik Thiel, Uwe Orlic-Milacic, Marija Zaidi, Syed
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Aberrant expression of the E26 transformation-specific (ETS) transcription factors characterizes numerous human malignancies. Many of these proteins, including EWS:FLI1 and EWS:ERG fusions in Ewing sarcoma (EwS) and TMPRSS2:ERG in prostate cancer (PCa), drive oncogenic programs via binding to GGAA repeats. We report here that both EWS:FLI1 and ERG ...
o’neill, allison f. nguyen, evelyn m. maldonado, evelyn d. chang, matthew r. sun, jiusong zhu, quan marasco, wayne a.
Background: Ewing sarcoma is a rare tumor of the bone or soft tissues characterized by diffuse membranous staining for CD99. As this tumor remains incurable in the metastatic, relapsed, and refractory settings, we explored the downstream immune implications of targeting CD99. Methods: We discovered a human anti-CD99 antibody (NOA2) by phagemid pann...
Fritchie, Karen J Ameline, Baptiste Andrei, Vanghelita Griffith, Christopher Shah, Akeesha A Dermawan, Josephine K Trucco, Matteo Budd, Thomas Thangaiah, Judith J Molligan, Jeremy
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Published in
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Adamantinoma-like Ewing sarcoma (ALES) has traditionally been considered a variant of Ewing sarcoma because it generally harbors EWSR1::FLI1 fusions despite showing diffuse positivity for keratins and p40. However, it has become increasingly recognized that different tumors can have identical translocations, including shared fusions between carcino...
Wiemels, Joseph L Wang, Rong Feng, Qianxi Yee, Amy C Morimoto, Libby M Metayer, Catherine Ma, Xiaomei
PurposeThe incidence of Ewing sarcoma varies according to race and ethnicity, and genetic susceptibility is known to affect disease risk. Apart from these factors, the etiology of Ewing sarcoma is largely unknown.MethodsWe compared the birth characteristics of a population-based series of 556 Ewing sarcoma cases born in California in 1978-2015 and ...
Zare, Farzaneh Shahbazi, Niloofar Faraji, Navid Goli, Rasoul Mostafaei, Behnam Anari, Sina
Published in
International journal of surgery case reports
Ewing's sarcoma, a highly malignant bone tumor, typically affects the pelvis and long bones of the lower extremities in children and young adults; primary involvement of the skull is rare. Primary Ewing's sarcoma arising from the skull is very rare. In most cases, this disease is fatal, although the prognosis of Ewing sarcoma improves with radiatio...
Digklia, Antonia Dolcan, Ana Kucharczyk, Monika A Jones, Robin L Napolitano, Andrea
Published in
Cancer management and research
Ewing sarcoma (ES) is a rare, highly malignant sarcoma. It usually presents in the second decade of life; however, patients can be diagnosed as early as newborns and as late as in their seventies. ES is most frequently found in the long bones of the extremities and the pelvis. In older patients, ES can also arise in the soft tissues. Currently, the...
Raux, Sébastien Ducrot, Coline Marec-Bérard, Perrine Corradini, Nadège Claude, Line Dijoud, Frédérique Picard, Cécile Bouhamama, Amine Chotel, Franck
Published in
Orthopaedics & traumatology, surgery & research : OTSR
Epiphyseal preservation surgery and biological reconstruction after resection of metaphyseal bone sarcoma in children is a surgical challenge which can only be justified if future joint function is maintained. The main hypothesis of this work was that long-term function was maintained. The secondary hypotheses were that local control of the disease...
Chen, Helen Seibel, Nita Boron, Matthew Terezakis, Stephanie Hill-Kayser, Christine Hayes, Andrea Reid, Joel Teot, Lisa Rakheja, Dinesh Womer, Richard
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PURPOSE: Monoclonal antibodies directed against insulin-like growth factor-1 receptor (IGF-1R) have shown activity in patients with relapsed Ewing sarcoma. The primary objective of Childrens Oncology Group trial AEWS1221 was to determine if the addition of the IGF-1R monoclonal antibody ganitumab to interval-compressed chemotherapy improves event-f...
Arnold, Michael T Geiger, Erik J Hart, Christopher Greig, Danielle Trikha, Rishi Sekimura, Troy Eckardt, Jeffrey J Bernthal, Nicholas M
BackgroundThe durability of endoprostheses after limb salvage surgery is influenced by surgical factors (resection length, implant location, and residual bone quality), implant design (modular versus custom design, rotating versus fixed hinge, coating, collars, and the use of cross pins), and host factors (patient's immune status, activity levels, ...