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with Estrogen receptor pathway as keyword
Gastiazoro, M P Durando, M Milesi, M M Lorenz, V Vollmer, G Varayoud, J Zierau, O
Published in
Molecular and cellular endocrinology
Glyphosate based herbicides are the most commonly used herbicide in the world. We aimed to determine whether glyphosate (Gly) induces epithelial mesenchymal transition (EMT) - related changes in a human endometrial carcinoma cell line (Ishikawa cells), and whether the estrogen receptor (ER) pathway is involved in these changes. Ishikawa cells were ...
Zhang, Qi Wu, Shuang Liu, Lu Hou, Xiaohong Jiang, Jianjun Wei, Xuetao Hao, Weidong
Published in
Journal of applied toxicology : JAT
Bisphenol A (BPA) is widely used as the raw material for the production of plastics and paper products. People can be exposed to BPA through dermal contact, particularly for cashiers in contact with thermal paper every day. BPA is a known endocrine disruptor that has been shown to be carcinogenic. Many tumors show weak gap junctional intercellular ...
Liu, Dingxie
Published in
Cellular Oncology
PurposeRecurrence is a major cause of colorectal cancer (CRC)-related death. As yet, the accurate identification of CRC patients at high risk of recurrence is still a major clinical challenge. Previously, we found that an estrogen receptor (ER) pathway gene signature may predict disease recurrence in CRC patients. The aim of this study is to evalua...
Saito, Ryoko Miki, Yasuhiro Hata, Shuko Ishida, Takanori Suzuki, Takashi Ohuchi, Noriaki Sasano, Hironobu
Published in
Breast Cancer Research and Treatment
PurposeAryl hydrocarbon receptor (AhR) inhibits estrogen receptor (ER) pathway, which may suppress estrogen-dependent cell proliferation. However, the correlation between AhR stimulation and intratumoral estrogen synthesis, especially through aromatase, has not been reported to date. In the present study, we examined this correlation in breast canc...
Takada, Mamoru Higuchi, Toru Tozuka, Katsunori Takei, Hiroyuki Haruta, Masayuki Watanabe, Junko Kasai, Fumio Inoue, Kenichi Kurosumi, Masafumi Miyazaki, Masaru
...
Published in
BMC Cancer
BackgroundChemotherapy with trastuzumab is widely used for patients with human epidermal growth factor receptor 2-positive (HER2+) breast cancer, but a significant number of patients with the tumor fail to respond, or relapse. The mechanisms of recurrence and biomarkers that indicate the response to the chemotherapy and outcome are not fully invest...
