Chang*, Kevin Wei-Lun Kwok*, Lai Lai Rana*, Manish K. Patel, Sapna Birris, Thomas
Published in
The American Journal of Case Reports
Patient: Female, 72-year-old Final Diagnosis: Paraneoplastic leukemoid reaction Symptoms: Anemia Medication:— Clinical Procedure: — Specialty: Oncology Objective: Rare disease Background: The presence of leukocytosis associated with non-hematological malignancy after ruling out other causes is defined as paraneoplastic leukemoid reaction (PLR). PLR...
Sami, Sarmed S Ravindran, Adharsh Kahn, Allon Snyder, Diana Santiago, Jose Ortiz-Fernandez-Sordo, Jacobo Tan, Wei Keith Dierkhising, Ross A Crook, Julia E Heckman, Michael G
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Que, Jianwen Garman, Katherine S Souza, Rhonda F Spechler, Stuart Jon
Published in
Gastroenterology
In patients with Barrett's esophagus (BE), metaplastic columnar mucosa containing epithelial cells with gastric and intestinal features replaces esophageal squamous mucosa damaged by gastroesophageal reflux disease. This condition is estimated to affect 5.6% of adults in the United States, and is a major risk factor for esophageal adenocarcinoma. D...
Kitano, Taku Aisu, Yuki Yasukawa, Daiki Hori, Tomohide
Published in
The American Journal of Case Reports
Case series Patients: Male, 54 • Male, 70 • Male, 59 Final Diagnosis: Esophagogastric junction adenocarcinoma Symptoms: Epigastralgia Medication: — Clinical Procedure: Aggressive therapy Specialty: Surgery Objective: Unusual clinical course Background: Three patients with stage IV esophagogastric junction cancer (EGJC) underwent extended resection ...
Crehange, G. Mabrut, J.-Y. Rouffiac, M.
Le traitement du cancer de l’œsophage localement évolué continue d’évoluer. La chirurgie a longtemps été considérée comme le seul traitement standard, mais la chimioradiothérapie a pris une place majeure dans la stratégie thérapeutique, soit en situation préopératoire, soit à visée exclusive. Bien que certains patients bénéficient toujours de la ch...
Shitara, Kohei; Özgüroğlu, Mustafa; Bang, Yung-Jue; Di Bartolomeo, Maria; Mandalà, Mario; Ryu, Min-Hee; Fornaro, Lorenzo; Olesiński, Tomasz; Caglevic, Christian; Chung, Hyun C;
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BACKGROUND: Patients with advanced gastric or gastro-oesophageal junction cancer that progresses on chemotherapy have poor outcomes. We compared pembrolizumab with paclitaxel in patients with advanced gastric or gastro-oesophageal junction cancer that progressed on first-line chemotherapy with a platinum and fluoropyrimidine. METHODS: This randomis...
Kauppila, Joonas H. Ringborg, Cecilia Johar, Asif Lagergren, Jesper Lagergren, Pernilla
Published in
Gastric Cancer
BackgroundThe postoperative health-related quality of life (HRQOL) outcomes in patients with gastroesophageal junction (GEJ) adenocarcinoma after gastrectomy and esophagectomy are unclear. The aim was to evaluate HRQOL outcomes 6 months after extended total gastrectomy, subtotal esophagectomy, and combined esophagogastrectomy.MethodsPatients who un...
Zifan, Ali Kumar, Dushyant Cheng, Leo K Mittal, Ravinder K
Studies to date have failed to reveal the anatomical counterpart of the lower esophageal sphincter (LES). We assessed the LES and esophageal hiatus morphology using a block containing the human LES and crural diaphragm, serially sectioned at 50 μm intervals and imaged at 8.2 μm/pixel resolution. A 3D reconstruction of the tissue block was reconstru...
Menezes, Mariano A. Herbella, Fernando A. M.
Published in
World Journal of Surgery
Gastroesophageal reflux disease pathophysiology is multifactorial and linked to a misbalance between the aggressiveness of the refluxate into the esophagus or adjacent organs and the failure of protective mechanisms associate or not to a defective valvular mechanism at the level of the esophagogastric junction incapable of dealing with a transdiaph...
Segal, J Lagundoye, A Carter, M
A 50-year-old male with a 7 month history of progressive dysphagia to solids then subsequently to liquids. He underwent a diagnostic gastroscopy which was normal. A further barium swallow suggested achalasia. He was referred to a tertiary centre, where he underwent pH and manometry studies which confirmed a diagnosis of achalasia. He was referred f...